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Review Article

鸡胚绒毛膜尿囊膜模型：一种体内外实验的研究方法

卷 29, 期 10, 2022

发表于: 25 June, 2021

页: [1702 - 1717] 页: 16

弟呕挨: 10.2174/0929867328666210625105438

价格: $65

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摘要

背景：鸡绒毛膜尿囊膜(CAM)模型作为动物模型的替代或补充的体内实验，在药物和生物学研究中引起了极大的兴趣。传统上，CAM检测方法已被广泛用于进行一些毒理学研究，特别是用于评估新药和配方的皮肤、眼部和胚胎毒性，以及进行血管生成研究。由于有可能在CAM上产生肿瘤，该模型也已成为评估不同肿瘤的转移潜能和在体内测试新型抗癌疗法的疗效的一个极好的策略。此外，近年来，它在其他研究领域的应用也大幅增长，包括对新的抗感染药物的评价、生物分布研究的发展和组织工程研究。 目的：本文提供了一个关键的概述使用CAM模型在药物和生物研究，特别是测试新药的毒性和配方和生物分布和小说抗癌和抗感染疗法的功效，分析其优缺点与动物模型。 结论：鸡绒毛膜尿囊膜模型在癌症、毒理学、生物分布研究和抗感染治疗等多个研究领域具有广阔的应用价值。事实上，它已经成为体外实验和动物研究之间的中间阶段，在毒理学研究（皮肤和眼部的毒性）中，它甚至取代了动物模型。

关键词: 血管生成，CAM检测，癌症，体外，HET-CAM检测，蛋，体内，毒理学研究。

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