摘要
背景:迄今为止,许多新颖且有吸引力的材料已应用于药物递送系统 (DDD),以提高癌症治疗的效率。稳定性低、毒性大、靶向能力弱等问题阻碍了大部分材料在生物医学领域的进一步应用。 MIL(MIL = Materials of Institute Lavoisier)作为金属有机框架(MOFs)的一个特定子类,比其他子类MOFs具有更多的优势,如更好的生物降解性和更低的细胞毒性。然而,到目前为止,尽管大多数文献都讨论了多孔材料 MOF 的一个研究分支,但很少有系统地分析和分析 Fe 基 MIL 在医疗应用中的应用。
讨论:在这篇综述中,我们主要关注最新的应用研究,包括基于 Fe 的 MIL 的生物成像、生物传感、抗菌和药物递送。还简要讨论了铁基 MIL 材料在解决剂量和负载策略问题方面快速增长的生物医学应用的现有缺点和未来前景,并且对使用不同疗法的进一步研究将引起极大兴趣。
结论:本文综述了近年来铁基 MOFs 的设计和生物医学应用,包括生物传感、生物成像、抗菌剂和药物递送。
关键词: MOF、铁基 MOF、生物医学应用、DDS、MIL、癌症。
Current Medicinal Chemistry
Title:Recent Advances in Fe-MOF Compositions for Biomedical Applications
Volume: 28 Issue: 30
关键词: MOF、铁基 MOF、生物医学应用、DDS、MIL、癌症。
摘要:
Background: To date, number of new and attractive materials have been applied in drug delivery systems (DDDs) to improve the efficiency of the treatment of cancers. Some problems like low stability, toxicity and weak ability of targeting have hampered most of materials for further applications in biomedicine. MIL(MIL = Materials of Institute Lavoisier), as a specific subclass of metal-organic frameworks (MOFs) owns more advantages than other subclass MOFs, such as better biodegradability and lower cytotoxicity. However, until now, systematic -s and analyses of Fe-based MIL on medical applications are rarely though the majority of documents discussed one research branch of the porous materials MOFs.
Discussion: In this review, we have focussed mainly on the latest studies of applications, including bioimaging, biosensing, and antibacterial and drug delivery on Fe-based MIL. The existing shortcomings and future perspectives of the rapidly growing biomedical applications of Fe-based MIL materials addressing dosage and loading strategies issues are also discussed briefly, and further studies with the use of different therapies will be of great interest.
Conclusion: This article reviews the Fe-based MOFs design and biomedical application, including biosensing, bioimaging, antibacterial agent, and drug delivery in recent years.
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Cite this article as:
Recent Advances in Fe-MOF Compositions for Biomedical Applications, Current Medicinal Chemistry 2021; 28 (30) . https://dx.doi.org/10.2174/0929867328666210511014129
DOI https://dx.doi.org/10.2174/0929867328666210511014129 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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