摘要
炎症小体的研究主要集中在神经组织，特别是受损组织。目前大多数神经学文献都涉及到利用星形胶质细胞的体内和体外研究，因为星形胶质细胞表达细胞骨架胶质纤维酸性蛋白(GFAP)，这是神经病理学疾病的标志。研究表明，星形胶质细胞通过反应性星形胶质增生对所有形式的神经损伤或疾病都有反应。此外，科学家们一致认为炎症小体在神经炎症中发挥着重要作用。本文综述了炎性小体生物学的最新进展，描述了目前对炎性小体如何在大脑中触发的理解，并总结了炎性小体NLR在流行神经系统疾病中的相关性的文献。
关键词: 星形胶质细胞、炎性小体、神经系统疾病、炎症、信号传导、NOD-样受体。
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the Treatment of Chronic Inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
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