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Mini-Review Article

间充质干细胞疗法对COVID-19的可行性：迷你审查。

卷 20, 期 4, 2020

页: [285 - 288] 页: 4

弟呕挨: 10.2174/1566523220999200820172829

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摘要

感染SARS-CoV-2的患者携带冠状病毒病2019（COVID-19），该疾病涉及多个系统和器官，其中最常见的并发症是急性呼吸窘迫综合征（ARDS），主要是由于细胞因子风暴或免疫功能失调。因此，有许多严重并发症，例如细胞因子风暴综合征（CSS），其病死率很高。目前既没有特定的抗SARS-CoV-2药物也没有疫苗。当前的治疗主要依靠通过患者的免疫功能自我恢复。间充质干细胞（MSCs）是一种多能组织干细胞，具有强大的抗炎和免疫调节功能，抑制细胞因子风暴。此外，间充质干细胞具有强大的修复组织损伤的能力，并能降低严重并发症（如急性肺损伤和ARDS）的风险，并有望降低这些患者的死亡率。目前已经完成了几种用MSC治疗COVID-19的临床研究，所有研究都报告了T细胞的恢复和临床安全性。在这里，我们讨论了临床前景，并总结了MSC治疗COVID-19的疗效和潜在机制。

关键词: 间充质干细胞，免疫，调节，修复，COVID-19，分泌组。

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