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Review Article

长非编码RNA UCA1在人类多发性癌症中的功能作用：综述研究。

卷 21, 期 2, 2021

发表于: 19 June, 2020

页: [96 - 110] 页: 15

弟呕挨: 10.2174/1566524020666200619124543

价格: $65

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摘要

在各种癌症中，已证实lncRNAs UCA1上调的患者患有高级别肿瘤，生存率低。尿道癌相关1（UCA1）是一种致癌的非编码RNA，长度超过200个核苷酸。 UCA1调节与癌症进展有关的关键生物学过程，包括癌细胞的生长，侵袭，迁移，转移和血管生成。因此，UCA1在多种癌症类型中过表达并不奇怪，包括胰腺癌，卵巢癌，胃癌，结肠直肠癌，乳腺癌，前列腺癌，子宫内膜癌，宫颈癌，膀胱癌，肾上腺癌，下咽癌，口腔癌，胆囊癌，鼻咽癌，喉癌，骨肉瘤，食道鳞状细胞癌，肾细胞癌，胆管癌，白血病，神经胶质瘤，甲状腺癌，髓母细胞瘤，肝细胞癌和多发性骨髓瘤。在本文中，我们综述了UCA1在几种癌症中的生物学功能和调控机制，还将讨论其作为癌症生物标志物和癌症治疗方法的潜力。

关键词: 长非编码RNA，UCA1，癌症，调节机制，生物标记物，治疗。

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