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Research Article

巴特病尿胎贫血致胎儿心细胞损伤

卷 21, 期 2, 2021

发表于: 10 June, 2020

页: [165 - 175] 页: 11

弟呕挨: 10.2174/1566524020666200610163546

价格: $65

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摘要

背景：严重的胎儿贫血会导致高输出心力衰竭。线粒体是心脏功能的关键调节器。但是，胎儿贫血的早期对胎儿心脏和心脏线粒体功能的影响尚不清楚。 目的：本研究的目的是比较贫血胎儿和非贫血胎儿的线粒体功能和胎儿心脏组织中的心脏生化变化。 材料与方法：在17-20周时对受Hb Bart病（n = 18）和非贫血胎儿（n = 10）影响的胎儿进行了横断面研究。在所有病例中均进行了超声心动图检查，以评估产前心脏功能。妊娠终止后收集心脏组织，以确定心脏铁的积累，线粒体功能，包括线粒体ROS的产生，线粒体去极化和线粒体肿胀，线粒体动力学，炎症和凋亡。 结果：Hb Bart和非贫血组通过超声评估的产前心脏功能相当。与非贫血组相比，巴特组的心脏线粒体去极化和肿胀水平以及TNF-α水平明显更高。相反，Hb Bart研究组的抗炎（IL-10）水平明显降低。此外，在Bart组中，活性caspase-3和Bcl-2的表达也显着较高（P = 0.001，P = 0.035）。 Bart组的线粒体裂变蛋白表达（包括p-DRP1 /总DRP1）明显更高。但是，两组之间的心脏铁蓄积水平没有差异。 结论：尽管Bart和非贫血组的产前心脏功能相当，心脏铁的蓄积量相当，但胎儿贫血与心脏线粒体功能障碍，线粒体裂变增加以及炎症和细胞凋亡增加显着相关。这些发现表明，在没有心脏铁超负荷的胎儿贫血的早期阶段，可导致患有Hb Bart的胎儿的心脏线粒体功能障碍。

关键词: 贫血，细胞凋亡，心脏组织，心脏功能，胎儿，血红蛋白，巴特氏病，线粒体功能，氧化应激。

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