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Systematic Review Article

Renin-Angiotensin-Aldosterone System and Migraine: A Systematic Review of Human Studies

Author(s): Karina Lúcia Moreira Sassi, Laís Bhering Martins, Aline Silva de Miranda and Antonio Lucio Teixeira*

Volume 27, Issue 6, 2020

Page: [512 - 519] Pages: 8

DOI: 10.2174/0929866527666200129160136

Price: $65

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Abstract

Migraine is a common neurologic condition marked by recurrent episodes of headache. Its pathophysiology is highly complex involving neuronal, inflammatory and vascular mechanisms. The Renin-Angiotensin System (RAS) can modulate all these mechanism, being a potential pharmacological target for migraine treatment. We carried out a systematic review of the studies evaluating the involvement of RAS in patients with migraine. There is evidence from genetic studies exploring the relation between migraine and RAS-related genes and from clinical trials evaluating the efficacy of Angiotensin II Type 1 (AT1) receptor antagonists and angiotensin converting enzyme inhibitors in migraine prophylaxis. RAS seems to play a role in the pathophysiology of migraine, but more direct evidence is still missing.

Keywords: Renin, angiotensin, aldosterone, migraine, headache, genetics.

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