This reference explores the science of signaling mechanisms associated with diseases like endocrine, metabolic, and immune disorders which are linked to oxidative stress-mediated disease mechanisms. The common diseases in these categories include diabetes mellitus and arthritis and conditions defined by inflammation and autoimmunity. These diseases involve metabolic pathways mediated by reactive oxygen species or free radicals. The pathways are targets in the mechanism of drugs that aim to treat related disorders. The book covers key topics in free radical biology that help to understand the nature of the pathways and the pharmacology of the drugs that are designed to target them. 5 chapters elucidate the free radical biology of the diseases. 1. Role of free radical biology in diabetes mellitus 2. Role of GSK3 in the regulation of insulin release and glucose metabolism 3. Regulatory role of NRF2 in rheumatoid arthritis 4. Role of free radical biology in Alzheimer's disease 5. Regulatory role of immune cells mediated antibody on rheumatoid arthritis Key features: - Elucidates the key biochemical and pharmacological mechanisms that are mediated by free radicals in common endocrine, metabolic and immune diseases - Explains the activation of immunological factors (like RF and ACPA) that trigger inflammation and arthritis - Covers the role of free radicals in Alzheimer's disease and new interventions that target mitochondrial mechanisms - Systematically explains the molecular biology of free radicals with the help of schematic diagrams - Includes references for further reading The accessible and structured text in this reference makes it a suitable resource for all biomedical scientists, faculty, and postgraduate students in academia and industry.

The Chemistry inside Spices & Herbs: Research and Development brings comprehensive information about the chemistry of spices and herbs with a focus on recent research in this field. The book is an extensive 2-part collection of 20 chapters contributed by experts in phytochemistry with the aim to give the reader deep knowledge about phytochemical constituents in herbal plants and their benefits. The contents include reviews on the biochemistry and biotechnology of spices and herbs, herbal medicines, biologically active compounds and their role in therapeutics among other topics. Chapters which highlight natural drugs and their role in different diseases and special plants of clinical significance are also included. Part I focuses on the general aspects of spice biotechnology, structure activity relationships and the natural products that can be used to treat different diseases - such as neurological diseases, inflammation, pain and infections. This part also covers information about phenolic compounds, flavonoids and turmeric supplements. This book is an ideal resource for scholars (in life sciences, phytomedicine and natural product chemistry) and general readers who want to understand the importance of herbs, spices and traditional medicine in pharmaceutical and clinical research.

Chemistry of Bipyrazoles: Synthesis and Applications covers the synthetic pathways for all types of bipyrazoles. 5 chapters cover bipyrazole systems, N,N- and N,C-bipyrazoles, namely 1,1`-bipyrazole, 1,3`-bipyrazole, 1,4`-bipyrazole, 3,3`-bipyrazoles, 3,4`-bipyrazoles and 4,4`-bipyrazoles The contents explain several types of reactions: 1) condensation reactions of hydrazines with tetracarbonyls, dihydroxydicarbonyl compounds or pyrazole-based difunctional compounds; 2) 1,3-dipolar cycloaddition of pyrazole-based hydrazonoyl halides with activated methylene compounds; 3) metal catalyzed cross-coupling reactions. The book concludes with a chapter that details the applications of bipyrazole derivatives in different industries. Information about advanced concepts used in chemical engineering such as metal-organic frameworks (MOFs) and corrosion inhibition are highlighted. The book contents are presented in an easy-to-understand manner suitable for readers in organic chemistry at senior levels of education and industry expertise. Each chapter is supplemented with detailed references.

Frontiers in Natural Product Chemistry is a book series devoted to publishing monographs that highlight important advances in natural product chemistry. The series covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds, including research on natural substances derived from plants, microbes and animals. Reviews of structure elucidation, biological activity, organic and experimental synthesis of natural products as well as developments of new methods are also included in the series. Volume nine of the series brings together 7 reviews on a variety of natural products and sources along with a chapter on the basics of investigating antioxidant activity. Propolis and its key chemical constituents: a promising natural product in therapeutic applications Investigation of the effects of using omega-3 fatty acids on egg quality in functional egg production Quercetin, a flavonoid with remarkable anticancer activity Swertiamarin for the treatment of metabolic syndrome Overview of traditional uses, phytochemistry and pharmacology of Peganum harmala l. Investigation of measurement methods of antioxidant activity and involved mechanisms Recent progress on natural and synthetic flavanone and its derivatives Role of virgin coconut oil as a multiple health promoting functional oil

Advances in Organic Synthesis is a book series devoted to the latest advances in synthetic approaches towards challenging structures. The series presents comprehensive reviews written by eminent authorities on different synthetic approaches to selected target molecules and new methods developed to achieve specific synthetic transformations or optimal product yields. Advances in Organic Synthesis is essential for all organic chemists in academia and the industry who wish to keep abreast of rapid and important developments in the field. Contents of this volume include these 7 reviews: - Recent advances in copper-catalyzed heterocyclic syntheses - Application of modern green chemistry methods in the synthesis of quinolines, quinazolines and quinazolinones - Electroluminescence polymers-a review on synthesis by organic compounds - Multicomponent approach for the synthesis of xanthenes - From atoms to macromolecules: 100 years of polymer research - An overview of oxidizing and reducing agents in total synthesis - Amino acid-derived ionic liquids: novel biodegradable catalytic systems for green synthesis of heterocycles

This technical reference covers information about modern nanocatalysts and their applications in organic syntheses, electrochemistry and nanotechnology. The objective of this book is to present a review of the development of nanocatalysts in the fields of organic synthesis and electroanalysis over the last few decades. It provides readers comprehensive, systematic and updated information about the relevant topics. The reader is introduced to nanocatalysts, with the following chapters delving into the different chemical reactions in which they are involved. The topics covered include: carbon-carbon coupling reactions, aryl and organic carbon hetero atom coupling reactions, oxidation-reduction reactions, photocatalysis, heterocyclic reactions and multicomponent catalysis. The concluding chapters cover applications of nanocatalysts in electrochemical synthesis and sensing. The thirteen chapters demonstrate the value of a variety of catalysts that are important in chemical engineering processes. Advanced Nanocatalysis for Organic Synthesis and Electroanalysis delivers a quick and accessible reference on advanced nanocatalysis for a broad range of readers which includes graduate, postgraduate and Ph. D. students of chemical engineering as well as faculty members, research and development (R&D) personnel working in the industrial chemistry sector.

Advanced Physical Chemistry Practical Guide aims to improve the student’s understanding of theory through practical experience and by facilitating experimental exercises. The book covers a wide range of areas from basic to advanced experiments including the calibration of instruments as well as the use of software for accurate computational quantum chemical calculations. This book is divided into four sections: part I - general introduction, calibration of glassware, instruments and precautions part II - experiments that have a simple theoretical background and classical methods part III - experiments that are associated with more advanced theory, and technique that require a greater degree of experimental skill and instrumentation part IV – investigative experiments relying on computers Covering all aspects of classical, advanced and computational chemistry experiments, Advanced Physical Chemistry Practical Guide will enable students to gain confidence in their ability to perform a physical chemistry experiment and to appreciate the value of an experimental approach towards the subject. Advanced Physical Chemistry Practical Guide is an essential handbook for students and teachers at advanced levels who seek to learn practical knowledge about important aspects of physical chemistry.

Advanced Techniques of Analytical Chemistry explains analytical chemistry in an accessible manner for students. The book provides basic and practical knowledge that helps the learner to understand the methods used in conducting experiments. Readers will understand the key concepts of qualitative and quantitative analysis through easy-to-read chapters written for chemistry students. Volume 1 covers the topic of volumetric analysis in detail. Topic-wise chapters introduce the reader to volumetric titrations and then explain the range of titration techniques which include aqueous acid-base titration, non-aqueous titration, redox titration, complexometric titration and some miscellaneous methods like diazotisation titration, Kjeldahl’s method and the oxygen flask combustion method. The combination of basic and advanced methods makes this an ideal textbook for chemistry students at graduate and undergraduate levels as well as an ideal handbook for the laboratory instructor.

Applications of Modern Mass Spectrometry, Volume 2, covers the latest advances in mass spectrometry in scientific research. The series presents readers with information on the broad range of mass spectrometry techniques and configurations, data analysis, and practical applications. Each volume contains contributions from eminent researchers who present their findings in an easy-to-read format. The multidisciplinary nature of the works presented in each volume of this book series makes it a valuable reference on mass spectrometry to academic researchers and industrial R&D specialists in applied sciences, biochemistry, life sciences, and allied fields. The second volume of the series presents 6 reviews: Ion Mobility-Mass Spectrometry for Macromolecule Analysis - Recent Advancements in Detection of Organic Contaminants in Wastewater Using Advanced Mass Spectrometry - Poisonous Substances in Tropical Medicinal and Edible Plants: Traditional Uses, Toxicology, and Characterization by Hyphenated Mass Spectrometry Techniques - LC-MS Analysis of Endogenous Neuropeptides from Tissues of Central Nervous System: An Overview - Advances in Structural Proteomics Using Mass Spectrometry and Recent Trends of Modern Mass Spectrometry: Application towards Drug Discovery and Development Process.

Recent Advances in Analytical Techniques is a series of updates in techniques used in chemical analysis. Each volume presents a selection of chapters that explain different analytical techniques and their use in applied research. Readers will find updated information about developments in analytical methods such as chromatography, electrochemistry, optical sensor arrays for pharmaceutical and biomedical analysis. The fifth volume of the series features five reviews which demonstrate chemical analysis techniques applied in different disciplines. - Superior Aspects of Liquid Chromatography-Based Mass Spectrometers in Chiral Analysis - New Trends in Sample Preparation for Pharmaceutical and Biological Analysis by Chromatographic Methods - Qualitative and Quantitative Investigation of Bio Tissues using Microscopy and Data Mining - Analytical Techniques For Analysis of Metals and Minerals in The Soil Samples - Monitoring Therapeutic Response in Cancers: A Raman Spectroscopy Approach