Frontiers in Clinical Drug Research : Anti - infectives is a book series that brings updated reviews to readers interested in learning about advances in the development of pharmaceutical agents for the treatment of infectious diseases. The scope of the book series covers a range of topics including the chemistry, pharmacology, molecular biology and biochemistry of natural and synthetic drugs employed in the treatment of infectious diseases. Reviews in this series also include research on multi drug resistance and pre-clinical / clinical findings on novel antibiotics, vaccines, antifungal agents and antitubercular agents. Frontiers in Clinical Drug Research – Anti infectives is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critically important information for developing clinical trials and devising research plans in the field of anti infective drug discovery and epidemiology. The eighth volume of this series presents comprehensive reviews of interest to readers interested in the treatment of inflammatory diseases, new antiviral agents and strategies, specific antiprotozoal drugs that work against leishmania and helminths, and a study on potential agents against American foulbrood in honey bees. The 7 reviews included in this volume are: - Monoclonal antibodies as therapeutic agents for inflammatory diseases - Pharmacotherapy of emerging antiviral agents - Antiviral activity of vitamin D and COVID-19: current understanding - Anti-infectives to combat leishmaniasis - Anthelmintic drug discovery: current situation and future perspectives - Therapeutic targets for emerging Zika virus infection and vaccines in clinical trials - Agro-industrial waste: new source of raw material for the control of American foulbrood in honey bees

Frontiers in Clinical Drug Research – Anti Infectives (Volume 9) is a book series that provides updated reviews on the latest advancements in development of pharmaceutical agents for treating infectious diseases. The series covers various topics, including chemistry, pharmacology, molecular biology, and biochemistry of natural and synthetic drugs. Additionally, it addresses multi-drug resistance and pre-clinical/clinical findings on antibiotics, vaccines, antifungal agents, and antitubercular drugs. This series is an invaluable resource for pharmaceutical scientists and postgraduate students, offering critical information to support clinical trials and research in anti-infective drug discovery and epidemiology. The ninth volume presents five in-depth reviews, with topics including mature drugs and antivirals for COVID-19, bacteriocins as potent anti-infective agents, therapeutic interventions targeting free radicals in viral diseases, and a detailed exploration of natural anti-infective agents. The five reviews included in this volume are: - The role of mature drugs in the COVID-19 era - Antivirals to treat COVID-19 - Ribosomally synthesized bacteriocins as potent anti-infective agents - Therapeutic interventions against free radicals in viral diseases - A comprehensive overview of natural anti-infective agents

Animal disease models are a vital tool to study diseases and associated conditions. Studies on animal models can, in some cases, be used as a basis for modeling and understanding human diseases. Biomedical scientists face a challenge to choose the correct animal model to study disease pathology, and neurological diseases are no exception to this rule. <p> Animal Models for Neurological Disorders covers different animal models which have been used for studying neurological disorders. 13 topical chapters have been contributed by a group of experts on the subject with an aim to cover emerging experimental models of a range of neurological diseases encountered in the clinic including Alzheimer’s disease, psychosis, Parkinson’s, Huntington’s disease, vascular dementia, schizophrenia, multiple sclerosis and brain tumors, among others. The chapters also inform readers about relevant clinical correlations in each disease model where appropriate. <p> Animal Models for Neurological Disorders is intended for all scholarly researchers and students of biomedical sciences, pharmacology, medicine (oncology, neurology, psychiatry), pharmacy, biochemistry, and biotechnology. The organized contents of the book also serve as a quick reference point for scientists working in applied areas of neuroscience including the study of neurodegenerative diseases and cognitive dysfunction in living organisms.

A Blueprint for the Hard Problem of Consciousness addresses the fundamental mechanism that allows physical events to transcend into subjective experiences, termed the Hard Problem of Consciousness. Consciousness is made available as the abstract product of self-referent realization of information by strange loops through the levels of processing of the brain. Readers are introduced to the concept of the Hard Problem of Consciousness and related concepts followed by a critical discourse of different theories of consciousness. Next, the author identifies the fundamental flaw of the Integrated Information Theory (IIT) and proposes an alternative that avoids the cryptic intelligent design and panpsychism of the IIT. This author also demonstrates how something can be created out of nothing without resorting to quantum theory, while pointing out neurobiological alternatives to the bottom-up approach of quantum theories of consciousness. The book then delves into the philosophy of qualia in different physiological knowledge networks (spatial, temporal and olfactory, cortical signals, for example) to explain an action-based model consistent with the generational principles of Predictive Coding, which maps prediction and predictive-error signals for perceptual representations supporting integrated goal-directed behaviors. Conscious experiences are considered the outcome of abstractions realized out of map overlays and provided by sustained oscillatory activity. The key feature of this blueprint is that it offers a perspective of the Hard Problem of Consciousness from the point of view of the subject; the experience of &lsquo;being the subject&rsquo; is predicted to be the realization of inference inversely mapped out of hidden causes of global integrated actions. The author explains the consistencies of his blueprint with ideas of the Global Neuronal Workspace and the Adaptive Resonance Theory of consciousness as well as with the empirical evidence supporting the Integrated Information Theory. A Blueprint for the Hard Problem of Consciousness offers a unique perspective to readers interested in the scientific philosophy and cognitive neuroscience theory in relation to models of the theory of consciousness.

How do neurons work in processes that guide thought and action? This eBook answers this question by presenting an accurate analysis of all the physico-chemical phenomena occurring between interconnected neurons. Once researchers have this information, they can then build a functional catalog of neurons and understand the working behind the simplest physiological elements and these can hopefully be replicated into devices. Microscopic and macroscopic experimental results can assist in the study of sensorial analysis, instincts and motor control of skeletal muscles. The book also presents a description of memory at the cellular level and gives insights about the learning process in living systems. Such research has increased our understanding of the mechanisms of animal behaviors from the honeybee to the dog. In human beings, the efficiency of the same neural mechanisms overtakes a threshold when language allows building new abstract signals from previous abstract signals. Introduction to the Neural Basis of Action and Thought demonstrates to readers how physiological processes allow us to recall words and generate sentences and how these processes support abstract thought, action and self awareness. This book is a useful primer for anyone interested in cognitive sciences and related research.

This reference is the definitive guide to common neurodegenerative diseases that affect humans. The book covers mechanisms of some of the most well-known neurodegenerative diseases, their biomarkers, neuropharmacology, and emerging treatment strategies. The book introduces the subject of neurodegeneration by outlining the biochemistry, pathophysiology and multifactorial neurological mechanisms (the role of genetics, environmental factors and mitochondrial damage, for example). Next, it explains some of the most studied diseases, namely, Parkinson's Disease, Alzheimer's Disease, Huntington's Disease, and Multiple Sclerosis. Subsequent chapters delve into current knowledge about diagnostic and immunological biomarkers, followed by a summary of novel therapeutic strategies. Special attention has been given to the role of medicinal plants in attempting to treat neurodegenerative diseases, as well as the public health burden posed by these conditions. Key Features - give readers an overview of multifactorial disease mechanisms in neurodegeneration - covers some major neurodegenerative diseases in detail - covers diagnostic and immunological biomarkers - explores current therapeutic strategies and drug targets in common neurodegenerative diseases - offers a simple presentation with references for advanced readers The book is a suitable reference for all readers, including students, research scholars, and physicians who are interested in the mechanisms and treatment of neurodegenerative diseases.

Researchers have tried various effective treatments that prevent the progressive neurodegeneration of neurons within the brain. Parkinson’s disease (PD), Alzheimer’s disease (AD), and Multiple sclerosis (MS) are some of the most common neurodegenerative diseases (NDDs). Recent Advances in the Treatment of Neurodegenerative Disorders provides interesting updates on treatments of these neurological disorders. Ten chapters have been contributed by experts in pharmacology and give a unique perspective to reader on special topics in this area, including the treatment of neurodegenerative treatment of neurodegenerative disease through ayurveda and phytochemicals, the therapeutic role of vitamins in Parkinson’s disease, mushrooms in NDD treatment, MS treatment, ALS treatment and the use of nanoparticles and nano formulations in NDD treatment. This is an informative reference for pharmacologists, medicinal chemists and healthcare professionals (general practitioners and neurologists) seeking updates in the treatment of some common neurodegenerative disorders.

This monograph is a collection of selected articles on the subject of mood disorders such as depression and schizophrenia. It is divided into 3 sections: 1) Research methods in psychopharmacology - which highlights some established experimental techniques to study mood disorders in human and relevant animal models, 2) Pathophysiology of mood disorders – which explains the physiological and pharmacological mechanisms responsible for mood disorders and 3) New strategies for the treatment of mood disorders – a concluding section that provides recent examples on the beneficial effects of pharmacological and non-pharmacological interventions in the relief of mood disorders. The e-book serves as a primer for graduate students and researchers interested in the physiology and treatment of affective psychological disorders.