Bentham Briefs in Biomedicine and Pharmacotherapy brings new trends and techniques in pharmacology and medical biochemistry to the forefront through unique volumes. Each volume provides a brief review of selected topics, written by scientific experts. The book series is essential reading for graduate students and researchers in pharmacology and life sciences as well as medical professionals seeking knowledge for research oriented projects. The first volume, Oxidative Stress and Natural Antioxidants, is a compilation of articles about free radicals (which are extremely reactive, short-lived molecules with unpaired electron valency), and antioxidants (which are stabilizing agents of free radicals in the body). The volume presents 17 chapters on the biochemistry of free radicals and antioxidants, with contributions from over 60 scientists. Readers will understand the basic and clinical aspects of free radical biomedicine, the role of antioxidants in neutralizing free radicals through physiological homeostasis, as well as the range of natural compounds which can be used to combat oxidative stress. The chapters also cover special topics such as recent advances in preparation methods of antioxidants, and industrial applications of antioxidants. The range of topics in this volume provide a consolidated reference for a broad set of readers on the subject.

Better Life and Business: Cell, Brain, Mind and Sex Universal Laws is an e-book that defines the fascinating new discipline: BRAINLIFEBIZ . BRAINLIFEBIZ combines new discoveries in neurobiology, behavior and medicine with novel concepts related to conscious software programming, automation, system adaptation, module selection , self -organization and automatic discovery. In other words, BRAINLIFEBIZ is a science of the consciousness, bio quantum / random chaos computations, self-organized event trains and processes with several conditions (continuous and discrete; without leadership and central control etc.). The goal of BRAINLIFEBIZ is to create a perfect computer model that simulates animal and human behavior in a computerized experimental setting. This volume presents simulations of the firefly, cricket, katydid, frog, bird and human prefrontal cortex. The book breaks across the lines that separate scientific disciplines. It explains the global nature of the specific intelligent systems outlined above. These intelligent systems features include learning, self- organization, fuzzy logic, high speed signal processing and process control. These features are employed to generate an intelligence map. The map presents figures and equations, curves and data for major ‘Elementary Processes’: aggression, mimicry, chaos , trains, pile up, attractions, courting, mating, emotion, reasoning and consciousness . ‘Elementary Processes’ are then simulated to interact with each other and form millions of complex processes explained by universal laws behind the cell, brain, mind, sex. These laws explain, in a new way, natural selection and reproductive success in the local and global society and business. These laws can be applied in a variety of situations - from everyday stress-free life, to intelligent business decision making, but with a solid biomedical and scientific foundation. The theory behind intelligent systems can be viewed as a complement to the genetic DNA code. The brain generates various brain event trains which allow it to store information in dispersed neural networks (biologically speaking, in 25 billions of neurons some of which with thousands of synapses dispersed over the cortex). The book explains the fast, precise and clear neural diagnostic processas well as the extremely flexible powerful leader mind. Better Life and Business: Cell, Brain, Mind and Sex Universal Laws is, therefore, a valuable reference for researchers to the fascinating world of natural and man -made intelligent systems and their applications in business situations and personal lives.

Aluminium is a chemical element present in earth’s crust and it is a known environmental toxin which has been found to be associated with various neurological disorders. Aluminium has been found to be a very strong risk factor for the development of Alzheimer’s disease. Biochemical Mechanisms of Aluminium Induced Neurological Disorders explains the association of aluminium with neurological disorders. The book introduces the reader to sources of aluminium exposure, followed by an explanation of pharmacokinetics of aluminium and the different biochemical pathways that cause neurological effects. Chapters cover the typical mechanisms associated with aluminium neurotoxicity such as synaptic impairment as well as recent topics of interest such as the role of aluminum in impairing blood-brain barrier functions. Separate chapters which cover clinical evidence of aluminium toxicity and its management are also included in the book. Biochemical Mechanisms of Aluminium Induced Neurological Disorders is a concise, yet informative reference on the subject of aluminium neurotoxicity for all readers, whether they are students of biochemistry, pharmacology and toxicology, clinical neurologists, environmentalists interested in metal pollution or general readers who want to learn about the toxic effects of aluminium in humans.

Biochemistry: Fundamentals and Bioenergetics presents information about the basic and applied aspects of the chemistry of living organisms. The textbook covers the scope and importance of biochemistry, the latest physical techniques to determine biomolecular structure, detailed classification, structure and function of biomolecules such as carbohydrates, lipids, amino acids, proteins, nucleic acids, vitamins, enzymes and hormones. Readers will also learn about processes central to energy metabolism including photosynthesis and respiration, oxidative phosphorylation, DNA replication, transcription and translation, recombinant DNA technology. Key Features - logical approach to biochemistry with several examples - 10 organized chapters on biochemistry fundamentals and metabolism - focus on biomolecules and biochemical processes - references for further reading

This brief book is dedicated to the quantitative analyses and systematic discussion of spatial biodiversity and biogeographic patterns in the Asia‐pacific region comprised of China, India and adjacent countries. The book is split into two sections. The first section presents readers with detailed statistical methods to conduct spatial macro‐biodiversity and biogeography analyses. Step-by-step instructions on how to perform these statistical methods by using the statistical program R are also provided. In the second part, different quantitative case studies are presented covering several topics, including phylogenetics, spatial statistics, multivariate statistics and ecological genomics. Each case study concludes with a detailed interpretation of the quantitative results and how these results are relevant to local and regional ecological processes. This reference is suitable for academics interested in biostatistics biodiversity and ecological studies specific to the Asia Pacific region and China.

Most findings about molecular interactions and cellular regulatory events are published in peer-reviewed scientific literature in the form of scientific jargon. The computerized text-mining algorithms are used to convert free grammar of human language into a set of formalized relationships between biological concepts in order to use this wealth of information. The compendium of such interactions extracted from an entire set of biomedical literature is a called knowledge network. Knowledge networks are the first step in the process of digitizing molecular biological knowledge. The next step is building molecular models depicting principal molecular events that govern various biological processes. Data mining in knowledge networks is the essence of building new biological models. The purpose is to elucidate major pathways of information flow through a molecular physical interaction network that happens during a disease, a cell process or an experiment. Such models contain key proteins involved in the process and can be used for prioritizing disease targets, for understanding of drug action and prevention of drug-induced toxicities, for analysis of patient predispositions and design of personalized therapies, for design of diagnostic biomarkers and analysis of patient molecular data. This e-book contains detailed examples illustrating the path to the digital biology and computerized drug development for personalized medicine. It provides conceptual principals for building biological models and for applying the models to make predictions relevant for drug development and translational medicine. The e-book will also be useful for researchers who use high-throughput technologies for molecular profiling of disease and drug action. It provides examples for analysis of gene expression microarrays to infer biological models, to find biomarkers for drug response and for applications of high-throughput molecular profiling technologies for personalized medicine. Scientists in academia, in pharmaceutical industry as well as graduate students will benefit from reading this book. The illustrations from the book can also be readily used in taught courses for molecular biology and pharmacology.

The exponential increase in computing power in the late twentieth century has allowed researchers to gather, process and analyze large volumes of information and construct rational paradigms of systems. Life sciences are no exception and computing advances have led to the birth of fields such as functional genomics and bioinformatics and facilitated an expansion of our understanding of biological systems. Biological Systems: Complexity and Artificial Life is an essential primer on systems biology for biologists and researchers having a multidisciplinary background. The volume covers a variety of theoretical models explaining biological processes. The book starts with an introductory chapter on the classical molecular biology paradigm and progresses towards concepts related to enzyme kinetics, non equilibrium dynamics, cellular thermodynamics, molecular motion in cells and more. The book concludes with a philosophical note on the concept of the biological system.

Bioluminescence, the cold living light or the cold fire of the sea is extremely common in all oceans at all depths. However, this phenomenon is nearly absent in freshwater, with the exception of a freshwater limpet. More than 75% of deep-sea creatures have been reported to produce their own light. The luminescent marine plankton such as dinoflagellate, radiolarians, jellyfish, comb jellies, annelids, copepods, ostracods, mysids, amphipods, euphausiids, and tunicates form an important component in the marine food chain. Research on luminescent marine plankton is gaining momentum owing to its importance in life science research and medicine. The glowing Green Fluorescent Protein (GFP) extracted from the North Pacific jellyfish, Aqueorea victoria (for which the Japanese biologist, Osamu Shimonmura won the Nobel Prize in Chemistry in 2008) has helped shed light on key processes such as the spread of cancer, the development of brain cells, the growth of bacteria, damage to cells by Alzheimer's disease, and the development of insulin-producing cells in the pancreas. Therefore, it is difficult to underscore the importance of bioluminescence and the organisms associated with this phenomenon. Bioluminescent Marine Plankton is a unique reference that attempts to provide answers to questions about bioluminescence. The first of its kind, this book attempts to answer questions on the subject with a focus on planktonic organisms. 12 chapters provide information about the chemistry of bioluminescence, types of bioluminescent displays, distribution of bioluminescence among marine plankton, ecological functions and utility of planktonic bioluminescence. Chapters are dedicated to the biology and ecology of specific groups of plankton that span about 200 luminescent marine species. The detailed book is an essential compendium on marine plankton for a broad range of readers who want to learn about bioluminescent plankton. A list of detailed references is also provided for the benefit of teachers, students, researchers and enthusiasts interested in marine biology, aquaculture, and environmental sciences.

The biophysics of diving and decompression in the human body are complex. The average individual experiences atmospheric pressure swings of 3% at sea level and over 20% at altitudes greater than a mile. Divers and their equipment can experience compressions and decompressions in orders of greater magnitude than pressures outside water, all within considerably shorter time spans. The understanding of the mechanics behind diving is based on absolute pressure and pressure changes. While these mechanics are readily quantified in physics, chemistry, and engineering applications, the physiological and medical aspects of pressure changes in living systems need to be understood clearly to assess the safety of routine divers. This monograph is a compilation of a body of knowledge on biophysics, gas transport, bubble studies and physiological models used for diving and hyperbaric applications. Information in the monograph is divided into three parts that cover biophysics and models, data correlation and validation approaches and practical applications, respectively. The book is a useful resource for researchers and maritime professionals who wish to understand the biophysics behind underwater diving and decompression for the purpose of maritime operations as well as diving simulation applications.

Waste management is one of the major challenges for environmental and public health organizations for maintaining safety standards in any area. Population growth and urbanization increase the difficulty in maintaining a sustainable waste management system. Bioremediation refers to the use of living organisms in processes designed to remove toxic chemicals present in waste material. Bioremediation represents a sustainable way to remove a range of environmental pollutants. Bioremediation: Challenges and Advancements covers the subject of bioremediation in eight chapters that focus on a broad range of waste sources, their adverse impacts on the ecosystem, and the advanced strategies for their remediation. Each chapter also highlights the problems encountered in bioremediation processes. Key features: - Comprehensive coverage of bioremediation in 8 reader-friendly chapters - Highlights methods and challenges of bioremediation in one volume. - Introduces the reader to bioremediation - Explains recent biotechnological methods for removing heavy metals and xenobiotic compounds - Describes strategies including physical, chemical, and biological methods to mitigate radioactive waste from contaminated sites and water bodies - Details the use of microbial-aided remediation techniques for the management of biomedical and electronic wastes, and its impact on the ecosystem - Describes bioremediation technologies for decontamination of solid waste pollutants - Showcases the application of Omics approaches such as genomics, transcriptomics, proteomics, and metabolomics to improve bioremediation processes. - Covers bioremediation of agro-wastes - Includes detailed references This book is an informative reference for scholars (researchers, undergraduate and graduate students of environmental sciences, microbiology and biotechnology) professionals (environmental engineers) and researchers, giving each a good understanding of the significance of bioremediation in solid waste management and the restoration of contaminated sites.