Organotins are widespread contaminants especially of water environments. Their chemically versatile structure makes organotin compounds able to bind to a variety of biomolecules thus widely affecting biological functions. Trisubstituted molecules, namely tributyltin (TBT) and triphenyltin (TPhT), have been widely employed in antifouling paints and are also exploited as plastic stabilizers that unfortunately cause harmful biological effects. Persistent bioaccumulation has resulted in organotins becoming a significant environmental threat. Chapter by chapter, the biological and biochemical effects of organotins are unravelled in this e-book by a careful analysis of the most recent findings with special focus on contaminant action mechanisms at cellular and molecular level. The e-book provides an intriguing insight into the molecular mechanisms involved in organotin toxicology thus serving as a useful reference to biochemists, biologists, ecotoxicologists and life science students.

This eBook presents a comprehensive review on the chemical composition of natural products derived from honeybee farming. These products include honey, pollen and propolis. Each chapter details specific products and the contents are complemented with an explanation of distinct analytical techniques for studying these products. Readers will also find a summary of current information about biological properties and applications of honey, pollen and propolis, which contribute to added value to these bee and plant-derived products. The eBook is a handy reference for students, researchers and laymen studying the biochemical aspects of apiculture.

Comparative bioacoustics is extraordinarily broad in scope. It includes the study of sound propagation, dispersion, attenuation, absorption, reverberation, and signal degradation as well as sound detection, recognition, and classification in both marine and terrestrial organisms (including humans). This research is informed by an understanding of the mechanisms underlying sound generation and aural reception, as well as the anatomy and physiology of the organs dedicated to these functions. Comparative Bioacoustics is the definitive introductory guide to the field of acoustics in animal and human biology. Key features of this volume are: -Comprehensive introduction to sound and related physical phenomena -Multidisciplinary and comparative analyses of bioacoustic phenomena -Integrated audio and video clips -Information about relevant research methods in bioacoustics Comparative Bioacoustics makes key information accessible to readers, therefore, meeting the requirements of both novice and advanced researchers preparing for a scholarly career in bioacoustics.

Computational biology in combination with large-scale biology has played a critical role in exploring the great potentials of embryonic stem cells, resulting in significant discoveries. This e-book brings together reviews and essays from different aspects of the embryonic stem cell research thus providing a comprehensive and updated introduction and reference specifically for computational biology of embryonic stem cells. Selected topics include focused analyses of the genome, transcriptome, epigenome, proteome, and regulatory network of embryonic stem cells, the theories and tools of computational biology used in these studies, and newly available databases and on-line resources for bioinformatics research. Future perspectives of related research activities are also addressed by various authors in this e- book. The book is a valuable reference and handbook for researchers and clinicians conducting stem cell research, as well as students and medical professionals interested in regenerative medicine, developmental biology, bioinformatics and computational biology.

Consanguineous marriages have been practiced for hundreds of years, predominantly by Moslems. Although it is generally accepted among communities that the social advantages outweigh other, the rate of congenital malformations and genetic diseases among the offspring borne of consanguineous marriages is higher and an increase in sterility, rates of abortions, stillbirths and neonatal deaths has been suggested by some researchers. These problems result in a substantial economic burden within the communities involved in the practice. Strategies for reducing the frequency of consanguineous marriages include expansion of educational programs, promotion of genetic testing services, and research to identify the genes responsible for genetic defects. Nowadays, with the migration of large numbers of Moslems towards Western countries, consanguinity is becoming a practical issue in places where it was barely known, previously. This eBook serves as a guide for health care workers and counselors of the phenomenon and its associated problems. This eBook begins with an introduction of the topic from a social, legal and biological perspective. It then progresses to research about associated genetic disorders, reproductive and social awareness issues through the proceeding chapters. The eBook concludes with 2 chapters exploring strategies to counter the effects of consanguinity within the general population.

Plasticity in insulin-producing cells (β-cells) of the pancreas is a major contributor to metabolic control. Targeted regeneration of pancreatic β-cells for the reversal of diabetes (by optimizing β-cells mass and proliferation to meet metabolic requirements and counter autoimmune response) is still a theoretical intervention. This monograph reviews the biology, ontogeny, capabilities, and present practical limitations of β-cell plasticity. Relevant biochemical pathways are described with the inclusion of information about how they change with aging, during pregnancy, and with diet. Readers will learn the following key aspects about β-cell plasticity: -current knowledge of pancreatic β-cells development, and how β-cell mass and proliferation change throughout the human lifespan -the mechanisms responsible for β-cell plasticity, based on animal models and clinical studies revealing environmental, epigenetic, endocrine and paracrine regulators -the therapeutic potential of resident stem cells within the pancreas / bone marrow and β-cell progenitors This monograph is essential reading for researchers interested in updated knowledge about the molecular and cellular biology of β-cells in the quest to find a reliable therapy for diabetes.

This volume brings current knowledge of proteomics technologies and related developments with special reference to diseases caused by microbes. The editor has compiled chapters written by expert academicians which distill the information about useful methods in microbial proteomics for the benefit of readers. Chapters cover several methods used to investigate the microbial proteome and special topics such as antimicrobial drug resistance mechanisms, biomarker developments, post translational modifications. Key Features: -overview of several biochemical methods in proteomics -full-color, high quality images of the most frequent technologies and applications -concise, well organized, and didactic format -updates in basic applied information -bibliographic references -information on proteomics for tuberculosis treatment This reference work is intended for researchers seeking information on laboratory techniques applied in proteomics research and microbiology.

Advances in biomedical research have had a profound effect on human health outcomes over the last century. Biophysical, biochemical and cellular techniques are now the backbone of modern biomedical research. Understanding these laboratory techniques is a prerequisite for investigating the processes responsible for human diseases and discovering new treatment methods. <p></p> Cutting Edge Techniques in Biophysics, Biochemistry and Cell Biology: From Principle to Applications Provides information about basic and advanced analytical techniques applied in specific areas of life science and biomedical <p></p> Key Features: <p></p> - Book chapters present a broad overview of sophisticated analytical techniques used in biophysics, biochemistry and cell biology. <p></p> - Techniques covered include in vitro cell culture techniques, flow cytometry, real time PCR, X-ray crystallography, RNA sequencing <p></p> - Information about industrial and biomedical applications of techniques, (drug screening, disease models, functional assays, disease diagnosis, gene expression analysis and protein structure determination) is included. <p></p> The book is an excellent introduction for students (as a textbook) and researchers (as a reference work). The information it presents will prepare readers to understand and develop research methods in life science laboratories for different projects and activities.

Dimorphism can be defined as the property of different fungal species to grow in the form of budding yeasts or in the form of mycelium, depending on the environmental conditions. Dimorphism may be considered as a differentiative phenomenon, similar to others exhibited by fungi: spore germination, sporulation, etc, but comparatively simple to analyze. Fungal dimorphism involves extensive changes in the cell physiology and morphology in response to external signals, producing drastic alterations in the cell wall structure and synthesis, whose growth pattern changes from isodiametric (spherical) to polarized or vice versa. Because of this, dimorphism has been the subject of extensive studies as a model for the differentiation processes occurring in eukaryotic organisms. Additionally, it is important to recall that the most important human pathogenic fungi, and some plant pathogenic ones are dimorphic, displaying different morphologies when growing as saprophytes, or inside their hosts. This observation, and the demonstration that mutants in specific genes that interfere with the dimorphic transition are non-virulent, has suggested that this process might be a target for efficient antimycotic drugs. This e-book includes several chapters on the most important and studied fungal models, written by specialists, discussing the biology of each species or genera, the general aspects controlling their dimorphic transition, the molecular aspects involved, the use of them as models for understanding the bases of biochemical and cell differentiation, and the importance of dimorphism in pathogenesis. This e-book is recommended for scholars and researchers working or interested in human, animal and plant pathogenesis, fungal genetics, molecular biology, development, evolution, and differentiation.

This book describes different medical problems that children with Down syndrome can encounter. Twelve chapters written by medical experts present information about the disease and give general guidelines for pediatric care. Readers are introduced to the epidemiology and risk factors associated with Down Syndrome followed by descriptions of medical issues related to the disease in children. These include neonatal problems, cardiac defects, respiratory disorders, gastrointestinal problems, nervous system disorders, dental disorders and more. The book also includes information on mental health development and social issues that arise in the lives of affected children. This handbook will be essential for medical students, healthcare professionals and special education personnel who are involved in the care of children with Down syndrome.