Micro RNAs (miRNAs) are known to play an important role in gene expression regulation. Owing to their ever-increasing implications in the control of various biological and pathological processes, miRNAs have now been considered novel biomarkers of various human diseases including, cancer, viral disease, cardiovascular disorders, metabolic disturbances, etc. Unique expression profiles have been associated with specific pathological states. Cardiovascular disease is among the main causes of mortality in developed countries. The pathological process of the heart is associated with altered expression profile of genes that are important for cardiac function. The implications of miRNAs in the pathological process of the cardiovascular system have recently been recognized, and the research on miRNAs in relation to cardiovascular disease is now in rapid progress. The aim of this ebook is to present updated research on the subject with analyses from published reports. Micro RNAs and Cardiovascular Disease caters to the growing interest and information needs of cardiac clinicians and gene expression researchers.

Historically, patients with advanced structural heart disease have required major surgery to correct the defect. This includes, for example, patients with atrial septal defect, aortic valve disease and mitral valve disease. In recent years there have been major advances in the treatment of patients with structural heart disease using minimally invasive, percutaneous treatments. This field continues to evolve quite quickly. This e-book outlines the current situation with respect to minimally invasive treatment of a wide range of structural cardiac defects. Each chapter covers details of a structural defect and outlines various technologies available for treating the condition. Indications for procedures as well as details of the procedures are also provided wherever possible. This e-book should be a useful reference for readers interested in minimally invasive cardiovascular surgery.

Nanomedicinal Approaches Towards Cardiovascular Disease summarizes information about nanotechnology that is used in the diagnosis and regenerative treatment of heart diseases. Chapters in this reference introduce the reader to the basics of cardiac nanomedicine and cardiac regeneration before moving to advanced topics such as nanomedicine in cardiovascular diagnosis, imaging and therapeutics. </P> Key Features </P> - 13 chapters that cover nanotechnological aspects of cardiovascular diseases, contributed by expert scholars </P> - Simple, reader-friendly text suitable for readers of all academic levels </P> - Covers introductory topics of nanomedicine regenerative medicine in cardiovascular disease, cardiovascular diagnosis and therapeutics </P> - Covers advanced topics such as cardiovascular nanotheranositics, cardiac reprogramming, biomimetics, drug delivery systems and smart nanomaterials </P> - Includes a chapter on ethical implications in cardiovascular nanomedicine </P> - Includes bibliographic references for each chapter </P> Nanomedicinal Approaches Towards Cardiovascular Disease is a simple. informative reference on cardiovascular nanomedicine for scholars, healthcare professionals and nanotechnology enthusiasts, alike, which provides holistic knowledge on the subject in a single volume.

Congenital heart diseases are the most common neonatal malformations, ranging from 8 to 15/1000 live births in various communities. Improvement of knowledge in the genetic and etio-pathogenic aspects of these malformations as well as the technical advances of diagnostic and therapeutic tools have brought about a significant improvement in overall long-term patient outcome over the last few decades. This e-book is an update on the most recent genetic, diagnostic and therapeutic aspects of this pediatric cardiology. Specifically, the book explains, in detail, recent acquisitions in the field of interaction between the genome and heart development, advances in diagnostic non-invasive techniques and novel therapeutic applications of the percutaneous and “hybrid” cardiologic/surgical procedures. These developments in diagnostics and therapeutics will be extremely valuable for both pediatric and adult cardiologists treating patients with congenital heart defects.

This book provides a comprehensive overview of current knowledge about research in oral infections and their association with cardiovascular diseases. Several epidemiological, clinical and other scientific aspects are covered in this book through the work of medical experts. The detailed accounts in this book are of great value to readers in the scientific community, practitioners, teachers and students in relevant fields, and health-care planners.

<p></p> In Perinatal Cardiology, fetal cardiology experts provide key information on tools for fetal evaluation through echocardiography / cardiac ultrasonography, with a primary focus on the nature and prenatal detection of structural and functional cardiac heart defects (CHDs). In this two-part book, readers will find details about different types of fetal cardiac abnormalities along with important updates on the diagnosis, management, planning delivery, and postnatal treatment in CHD cases. This information is supplemented with guidelines for the clinical management of patients with a fetus affected by cardiovascular defects, and surgical procedures in neonates. <p></p> Key Features: <p></p> -presents information gathered by experts in perinatal cardiology, organized into 26 topic-based chapters - explores the cardiac development, fetal cardiovascular hemodynamics, genetic and environmental factors associated with congenital heart defects (CHD), perinatal management, planning delivery, and postnatal treatment of newborns with CHD - presents information about normal cardiac functions and heart defects to give readers a clear and detailed picture of abnormal cardiac function - presents information about perinatal ultrasound physiology - gives practical guidelines for ultrasound and echography parameters required for evaluating fetal heart anatomy and diagnosing diseases - includes a new system of classifying prenatal CHDs based on the stratification of the risk level of care - features a straightforward and accessible style of presentation suitable for all readers - provides references in each chapter for further reading <p></p> Part 1 of this two-part set covers the basics of perinatal cardiology which chapters that introduce readers to CHD classification, fetal heart and placental physiology and pathology, diagnosis of fetal cardiac malposition and anomalies and some congenital heart defects such as septal defects, cardiac anomalies of the left and right sides, conotruncal anomalies and aortic arch anomalies. <p></p> Perinatal Cardiology is an essential reference for postgraduate medical students seeking to improve their knowledge of fetal and pediatric cardiology as part of their residency and professional training. The book equips readers with the information necessary to understand the role of the perinatal cardiologist and goes further to facilitate the ability to perform adequate risk assessments for fetal CHD. <p></p>

<p></p> In Perinatal Cardiology, fetal cardiology experts provide key information on tools for fetal evaluation through echocardiography / cardiac ultrasonography, with a primary focus on the nature and prenatal detection of structural and functional cardiac heart defects (CHDs). In this two-part book, readers will find details about different types of fetal cardiac abnormalities along with important updates on the diagnosis, management, planning delivery, and postnatal treatment in CHD cases. This information is supplemented with guidelines for the clinical management of patients with a fetus affected by cardiovascular defects, and surgical procedures in neonates. <p></p> Key Features: <p></p> -presents information gathered by experts in perinatal cardiology, organized into 26 topic-based chapters - explores the cardiac development, fetal cardiovascular hemodynamics, genetic and environmental factors associated with congenital heart defects (CHD), perinatal management, planning delivery, and postnatal treatment of newborns with CHD - presents information about normal cardiac functions and heart defects to give readers a clear and detailed picture of abnormal cardiac function - presents information about perinatal ultrasound physiology - gives practical guidelines for ultrasound and echography parameters required for evaluating fetal heart anatomy and diagnosing diseases - includes a new system of classifying prenatal CHDs based on the stratification of the risk level of care - features a straightforward and accessible style of presentation suitable for all readers - provides references in each chapter for further reading <p></p> Part 2 of this two-part set delves into different fetal anomalies such as ventricular inflow anomalies, myocardial and pericardial diseases, cardiac tumors, extra-cardiac conditions, cardiac failure, and environmental factors associated with CHD. The latter chapters cover clinical topics such as labor management for patients bearing a child with CHD, fetal cardiac interventions, clinical management of neonates with CHD and postnatal surgery. <p></p> Perinatal Cardiology is an essential reference for postgraduate medical students seeking to improve their knowledge of fetal and pediatric cardiology as part of their residency and professional training. The book equips readers with the information necessary to understand the role of the perinatal cardiologist and goes further to facilitate the ability to perform adequate risk assessments for fetal CHD. <p></p>

The simple assessment of atherosclerotic risk factors is not an accurate tool to predict the risk of cardiovascular disease (CVD) in adults without past history of atherosclerotic disease. Preclinical atherosclerotic increases the global cardiovascular risk and should be evaluated for a better risk stratification. Intima-media thickness (IMT), reduced ankle-brachial pressure index (ABI) and impaired flow mediated dilatation (FMD) are independent markers of multifocal but subclinical atherosclerosis and result associated with an increased rate of cardiovascular events. Multidetector computed tomography (MDCT) may be a useful non-invasive technique to detect silent coronary disease (CAD) in patients with peripheral preclinical atherosclerosis. This ebook outlines &ldquo;preclinical athersclerosis&rdquo; and its markers in clinical practice. The ebook gives simple but clear information for a better stratification of global cardiovascular risk. The text serves as an important guide for medical professionals involved in the management of cardiovascular patients.

Type A acute aortic dissection (TAAAD) is an acute cardiovascular condition that is normally associated with genetic conditions such as Marfan Syndrome, but it can also occur in patients with no known predisposing risk factors. TAAD is associated with extremely high mortality (over 20% of documented cases in medical literature) if not addressed on time. Surgical management of TAAAD also varies tremendously depending on the causative pathology. Techniques to manage TAAAD cover the entire spectrum of methods employed in cardiac surgery ranging from a simple replacement of the ascending aorta to aortic root sparing or replacement, and an aortocoronary bypass to total arch and descending aortic stenting involving hypothermic circulatory arrest or other cerebral protection strategies. New medical evidence suggests that concomitant, intraoperative management of the arch and descending aorta minimizes the need for subsequent surgeries in patients who are operated upon for TAAAD. Coupled with new diagnostic technology available to medical professionals, better long-term patient outcomes for TAAD treatment are now a reality. Recent Advances in Acute Type A Aortic Dissection presents a collection of comprehensive reviews from many experts on TAAAD. Cardiac surgeons can benefit from this volume by learning about current medical opinions and consensuses on risk factors (including genetic predisposition), diagnostic modalities, intraoperative management, surgical options, cerebral protection strategies, and long-term follow up procedures on acute TAAAD.

Despite remarkable progress in fighting against myocardial infarction, the thrombotic complications of the coronary artery are still a significant cause of morbidity and mortality worldwide. Treatment options for arterial thrombosis include either relatively old drugs such as streptokinase, and newer agents that are either approved by the FDA or still undergoing clinical trials. These options make some room for questions that lead to a conclusion for the best combination of drugs for treating patients with acute coronary syndromes. The handbook combines available information from basic hematology, cardiology and clinical trials and presents practical bed-side solutions for clinicians working with patients suffering from acute coronary syndromes. Readers will learn about the pathogenesis and diagnosis of thrombosis, thrombogenesis and fibrinolysis. Newer antithrombotic agents, cardiac diseases, venous thromboembolism are also covered. Health professionals will have quick access to relevant and organized information which also includes visual and tabular guides as well as some recommendations from professional societies.