Morphea and Related Disorders is a comprehensive reference on morphea. The book covers the subject in 20 chapters. The book starts with a detailed introduction and history of the morphea and its various classifications systems. Next, the book progresses into epidemiology, predisposing factors and pathogenic mechanisms, followed by histopathology for morphea diagnosis and a detailed review of clinical presentations. Subsequent chapters cover associated diseases and extracutaneous manifestations, medical investigations, treatment guidelines and special topics (Idiopathic atrophoderma of Pasini and Pierini, Linear atrophoderma of Moulin, Parry-Romberg syndrome, Lichen sclerosus, pediatric morphea and eosinophilic fasciitis). Key features: -he most detailed reference book on morphea -Easy and simple language for readers -Chapter synopsis at the beginning of each chapter -Learning points at the end of the chapter -More than 100 high resolution colored photographs -Information boxes and tables to enhance readability. -Covers basic knowledge on morphea, including pathogenesis, clinical presentations, and classification -Includes guidelines for professionals -Includes chapters on special topics for advanced readers Morphea and Related Disorders is the definitive reference book for medical students, residents, instructors, and physicians.

A Case-Based Approach to Interventional Pulmonology: A Focus on Asian Perspectives focuses on various aspects of Interventional Pulmonology (IP) based on clinical case scenarios. Today, evidence-based medicine and statistics are ruling our daily practice. Thus, each case is unique regardless of what the theory predicts. This asian perspective of Interventional Pulmonology (IP) is also of great importance, given the differences in the etiologies compared to other regions of the world. Asia being the leading region in terms of population and the high incidence of certain airway and lung diseases, is an amazing source for fundamental and clinical research. The contents of the book have been divided into four different sections with a primary aim of case-based scenarios and solutions. Section A consists of diagnostic IP procedures like linear and radial EBUS, navigation bronchoscopy, bronchoscopic lung cryobiopsy (BLC) and cone beam CT. Section B focuses on therapeutic rigid bronchoscopic procedures. Besides airway stenting and laser bronchoscopy, this discusses recent interventions such as bronchial thermoplasty, bronchoscopic lung volume reduction, 3D printing and microwave ablation. Section C is dedicated to pleural procedures focusing on indwelling pleural catheters (IPC) and fibrinolytics. Section D is dedicated to common paediatric IP procedures. Each case is presented with the history, including clinical, radiological, bronchoscopic/pleuroscopic findings and final outcomes. Many of these cases also have video illustrations.

Abdominal pain is one of the frequent reasons for admission to emergency departments in hospitals. Diagnosis in patients presenting abdominal pain is a challenge for physicians owing to several indications, and a lack of contraindications. Delay in diagnosis and misdiagnosis is a common problem even for the most experienced emergency physician or general surgeon. Disruptions that may be related to ancillary services such as radiology and biochemistry also increase the difficulty. Abdominal Pain: Essential Diagnosis and Management in Acute Medicine is a definitive diagnosis guide that serves as a quick reference that supplements medical examinations. It gives physicians involved in a range of medical specialties (emergency medicine, family medicine, gastroenterology, general surgery) an understanding of how to apply procedures to expediently relieve pain where possible, after evaluating and recording the initial vital signs and findings on systemic examination. Key Features - Covers abdominal pain diagnosis and patient management patient in a systematic and structured manner in 12 chapters - Chapters are dedicated to specific topics - Presents an individualized approach tailored for the patient to address common problems - Gives general working knowledge for specific diseases in the list of possible diagnoses - Provides a guide to situations involving trauma and surgery

Contemporary Endoscopic Spine Surgery brings the reader the most up-to-date information on the endoscopy of the spine. Key opinion leaders from around the world have come together to present the clinical evidence behind their competitive endoscopic spinal surgery protocols. Chapters in the series cover a range of aspects of spine surgery including spinal pain generators, preoperative workup with modern independent predictors of favorable clinical outcomes with endoscopy, anesthesia in an outpatient setting, management of complications, and a fresh look at technology advances in a historical context. The reader will have a first-row seat during the illustrative discussions of expanded surgical indications from herniated disc to more complex clinical problems, including stenosis, instability, and deformity in patients with advanced degenerative disease of the human spine. Contemporary Endoscopic Spine Surgery is divided into three volumes: Cervical Spine, Lumbar Spine, and Advanced Technologies to capture an accurate snapshot in time of this fast-moving field. It is intended as a comprehensive go-to reference text for surgeons in graduate residency and postgraduate fellowship training programs and for practicing spine surgeons interested in looking for the scientific foundation for expanding their clinical practice towards endoscopic surgery. This volume (Advanced Technologies) covers the following endoscopic spine surgery topics in 19 detailed chapters: endoscopic intradiscal therapy and foraminoplasty, evidence based medicine in spine surgery, artificial intelligence for spine surgery, postoperative management, transforaminal lumbar endoscopy and associated complications, laser applications in full endoscopy of the spine, high frequency surgery for the treatment of herniated discs, lumbar MRI, cost and maintenance management of endoscopic spine systems, regenerative medicine, interbody fusion, endoscopic intravertebral canal decompression after spinal fracture, treatment of lumbar tuberculosis, treatment of degenerative scoliosis, treatment of thoracic meningioma with spinal canal decompression, and cervical endoscopic unilateral laminotomy for bilateral decompression (CE-ULBD).

This reference work provides comprehensive information about diabetic nephropathy. Chapters in the book introduce the reader to the link between diabetes, obesity and chronic kidney disease (CKD) and delve into many topics relevant to treating kidney disease in diabetic patients. These topics include CKD epidemiology, diagnosis, treatment considerations for the elderly patient, post-transplant diabetes, pathophysiology, biomarkers and much more. Special topics such as the incidence of cardiovascular disease in diabetic CKD, nutrition for obese CKD patients and the clinical use of biomarkers for evaluating cases are also included. <p></p> The broad spectrum coverage of informative topics about diabetic kidney disease make this an essential reference for medical students and clinical residents/healthcare professionals in nephrology, endocrinology, geriatrics, internal medicine and general surgery. Researchers interested in the clinical biochemistry of diabetes and associated disorders will also benefit from the information presented.

Diabetes and the Eye familiarizes the reader with the relationship between diabetes mellitus and the visual system. It presents a discussion about the diabetes epidemic and the many ways the disease can cause vision loss, with several types of vision disorders covered in separate chapters. Information about new frontiers in the treatment of ophthalmic disorders is also presented to reflect the advances being made in the clinic. Key features: - presents detailed coverage of vision loss in diabetes in 12 organized and easy to read chapters - includes a discussion on the diabetes epidemic - covers a wide range of vision disorders, of different parts of the eye - includes information on current practices in eye care and management for diabetic patients - includes information about relevant diagnostic tools This book serves as a useful handbook for medical students, residents in ophthalmology, community and academic ophthalmologists, as well as members of the internal medicine and family practice communities.

PCR (Polymerase Chain Reaction) technology has become an indispensable component of routine veterinary diagnostics. However, a number of pitfalls and limiting factors affect its sensitivity and specificity of detection. It is imperative that veterinary PCR diagnosticians include such considerations in their work. Extensive experience with PCR technology in both research and diagnostic applications enables researchers to pinpoint these practical limitations, and therefore instruct the user in approaches that avoid these common errors. This E-book discusses the basic concepts, chemistries, and instrumentation of standard and real-time PCR, and includes present applications and future perspectives for veterinary diagnostics. Critical pitfalls have been highlighted in this text with regard to veterinary PCR diagnostics which include: i) choice of platform technologies for PCR diagnosis; ii) construction of optimized PCR primers and probes to ensure its highest specificity and sensitivity; iii) correct sampling and efficient methods to preserve and release nucleic acids; iv) maximization of PCR amplification efficiency; and v) avoidance and monitoring of contamination in Veterinary PCR Diagnostics. This eBook should be a valuable reference for all veterinary professionals interested in this modern diagnostic tool.

A multidisciplinary approach is increasingly being adapted by the Pharmaceutical industry to tackle several challenges in developing efficacious treatment solutions. The field of Ophthalmology is no less different. Treatise on Ocular Drug Delivery is a unique collection of information put together by various experts in the field. One of the major goals behind this volume is to link clinical information with the current strategies employed in ocular drug delivery. This monograph covers a range of topics on ocular pharmacology. Chapters in the e-book cover several aspects of drug delivery research such as the biochemical background of specific eye diseases, challenges for ocular drug delivery, the role of influx and efflux transporters, novel drug delivery systems, pharmacokinetics, regulatory aspects, and patenting opportunities for researchers. This E-Book would serve as a suitable reference for pharmacy graduates, medical students, professional scientists and ophthalmic clinicians in academic and industrial laboratories.

The main theme of this book is to critically survey the role of two recognized protein molecules (i.e., transcription factors) in processes of human memory. In addition, authors provided recent data from their own labs and provided a perspective relevant to specific neurological diseases and potential drug targets. Historically, the transcription factor cAMP response element-binding (CREB) has been the most well documented transcription factor shown to play a role in memory. CREB has several functions, but its most notable function has to do with the formation of long-term memories. More recently, other transcription factors, such as C/EBP, Egr protein, AP-1, and NF-&amp;kappa;B have been implicated in memory as well. Of these, scientific literature on NF-&amp;kappa;B&amp;rsquo;s theorized role in synaptic plasticity and memory is growing rapidly. Interestingly, in some recent studies CREB and NF-&amp;kappa;B have also been shown to interact with each other where both contribute in a cooperative fashion to the initiation of gene expression.

Nanotechnology has revolutionized cancer diagnosis and therapy through targeted drug delivery. Advances in protein engineering and materials science have led to the development of nanocarriers (NCs), which have helped overcome the challenges faced during conventional cancer treatment. These nanocarriers serve as an efficient transport module for drugs. Nano-drug delivery has emerged as a promising technology that results in early detection and better treatment of various cancers. The approved nanoparticles currently used in cancer treatment strategies include liposomes, dendrimers, polyplexes, solid lipid nano-carriers, etc. These nanocarriers shall provide a quick, safe, and cost-effective method in cancer therapy and management. This book contains thirteen chapters focusing on the treatment of various cancers, i.e., lung, breast, cervical, ovarian, colon, prostate, head and neck, etc., through nanocarrier drugs. The chapters include reviews on a wide variety of advanced data from existing and ongoing clinical research and major regulatory considerations. This reference book will greatly benefit undergraduate and postgraduate students, oncologists, pharmacists, and researchers involved in nanomedicine and nano-drug delivery.