Computational biology in combination with large-scale biology has played a critical role in exploring the great potentials of embryonic stem cells, resulting in significant discoveries. This e-book brings together reviews and essays from different aspects of the embryonic stem cell research thus providing a comprehensive and updated introduction and reference specifically for computational biology of embryonic stem cells. Selected topics include focused analyses of the genome, transcriptome, epigenome, proteome, and regulatory network of embryonic stem cells, the theories and tools of computational biology used in these studies, and newly available databases and on-line resources for bioinformatics research. Future perspectives of related research activities are also addressed by various authors in this e- book. The book is a valuable reference and handbook for researchers and clinicians conducting stem cell research, as well as students and medical professionals interested in regenerative medicine, developmental biology, bioinformatics and computational biology.

Consanguineous marriages have been practiced for hundreds of years, predominantly by Moslems. Although it is generally accepted among communities that the social advantages outweigh other, the rate of congenital malformations and genetic diseases among the offspring borne of consanguineous marriages is higher and an increase in sterility, rates of abortions, stillbirths and neonatal deaths has been suggested by some researchers. These problems result in a substantial economic burden within the communities involved in the practice. Strategies for reducing the frequency of consanguineous marriages include expansion of educational programs, promotion of genetic testing services, and research to identify the genes responsible for genetic defects. Nowadays, with the migration of large numbers of Moslems towards Western countries, consanguinity is becoming a practical issue in places where it was barely known, previously. This eBook serves as a guide for health care workers and counselors of the phenomenon and its associated problems. This eBook begins with an introduction of the topic from a social, legal and biological perspective. It then progresses to research about associated genetic disorders, reproductive and social awareness issues through the proceeding chapters. The eBook concludes with 2 chapters exploring strategies to counter the effects of consanguinity within the general population.

Plasticity in insulin-producing cells (β-cells) of the pancreas is a major contributor to metabolic control. Targeted regeneration of pancreatic β-cells for the reversal of diabetes (by optimizing β-cells mass and proliferation to meet metabolic requirements and counter autoimmune response) is still a theoretical intervention. This monograph reviews the biology, ontogeny, capabilities, and present practical limitations of β-cell plasticity. Relevant biochemical pathways are described with the inclusion of information about how they change with aging, during pregnancy, and with diet. Readers will learn the following key aspects about β-cell plasticity: -current knowledge of pancreatic β-cells development, and how β-cell mass and proliferation change throughout the human lifespan -the mechanisms responsible for β-cell plasticity, based on animal models and clinical studies revealing environmental, epigenetic, endocrine and paracrine regulators -the therapeutic potential of resident stem cells within the pancreas / bone marrow and β-cell progenitors This monograph is essential reading for researchers interested in updated knowledge about the molecular and cellular biology of β-cells in the quest to find a reliable therapy for diabetes.

This volume brings current knowledge of proteomics technologies and related developments with special reference to diseases caused by microbes. The editor has compiled chapters written by expert academicians which distill the information about useful methods in microbial proteomics for the benefit of readers. Chapters cover several methods used to investigate the microbial proteome and special topics such as antimicrobial drug resistance mechanisms, biomarker developments, post translational modifications. Key Features: -overview of several biochemical methods in proteomics -full-color, high quality images of the most frequent technologies and applications -concise, well organized, and didactic format -updates in basic applied information -bibliographic references -information on proteomics for tuberculosis treatment This reference work is intended for researchers seeking information on laboratory techniques applied in proteomics research and microbiology.

Advances in biomedical research have had a profound effect on human health outcomes over the last century. Biophysical, biochemical and cellular techniques are now the backbone of modern biomedical research. Understanding these laboratory techniques is a prerequisite for investigating the processes responsible for human diseases and discovering new treatment methods. <p></p> Cutting Edge Techniques in Biophysics, Biochemistry and Cell Biology: From Principle to Applications Provides information about basic and advanced analytical techniques applied in specific areas of life science and biomedical <p></p> Key Features: <p></p> - Book chapters present a broad overview of sophisticated analytical techniques used in biophysics, biochemistry and cell biology. <p></p> - Techniques covered include in vitro cell culture techniques, flow cytometry, real time PCR, X-ray crystallography, RNA sequencing <p></p> - Information about industrial and biomedical applications of techniques, (drug screening, disease models, functional assays, disease diagnosis, gene expression analysis and protein structure determination) is included. <p></p> The book is an excellent introduction for students (as a textbook) and researchers (as a reference work). The information it presents will prepare readers to understand and develop research methods in life science laboratories for different projects and activities.

Dimorphism can be defined as the property of different fungal species to grow in the form of budding yeasts or in the form of mycelium, depending on the environmental conditions. Dimorphism may be considered as a differentiative phenomenon, similar to others exhibited by fungi: spore germination, sporulation, etc, but comparatively simple to analyze. Fungal dimorphism involves extensive changes in the cell physiology and morphology in response to external signals, producing drastic alterations in the cell wall structure and synthesis, whose growth pattern changes from isodiametric (spherical) to polarized or vice versa. Because of this, dimorphism has been the subject of extensive studies as a model for the differentiation processes occurring in eukaryotic organisms. Additionally, it is important to recall that the most important human pathogenic fungi, and some plant pathogenic ones are dimorphic, displaying different morphologies when growing as saprophytes, or inside their hosts. This observation, and the demonstration that mutants in specific genes that interfere with the dimorphic transition are non-virulent, has suggested that this process might be a target for efficient antimycotic drugs. This e-book includes several chapters on the most important and studied fungal models, written by specialists, discussing the biology of each species or genera, the general aspects controlling their dimorphic transition, the molecular aspects involved, the use of them as models for understanding the bases of biochemical and cell differentiation, and the importance of dimorphism in pathogenesis. This e-book is recommended for scholars and researchers working or interested in human, animal and plant pathogenesis, fungal genetics, molecular biology, development, evolution, and differentiation.

This book describes different medical problems that children with Down syndrome can encounter. Twelve chapters written by medical experts present information about the disease and give general guidelines for pediatric care. Readers are introduced to the epidemiology and risk factors associated with Down Syndrome followed by descriptions of medical issues related to the disease in children. These include neonatal problems, cardiac defects, respiratory disorders, gastrointestinal problems, nervous system disorders, dental disorders and more. The book also includes information on mental health development and social issues that arise in the lives of affected children. This handbook will be essential for medical students, healthcare professionals and special education personnel who are involved in the care of children with Down syndrome.

Ecological Impacts of Toxic Chemicals presents a comprehensive, yet readable account of the known disturbances caused by all kinds of toxic chemicals on both aquatic and terrestrial ecosystems. Topics cover the sources of toxicants, their fate and distribution through the planet, their impacts on specific ecosystems, and their remediation by natural systems. Each chapter is written by well-known specialists in those areas, for the general public, students, and even scientists from outside this field. The book intends to raise awareness of the dangers of chemical pollution in a world dominated by industry and globalization of resources. Because the problems are widespread and far reaching, it is hoped that confronting the facts may prompt better management practices at industrial, agricultural and all levels of management, from local to governmental, so as to reduce the negative impacts of chemical contaminants on our planet.

Cultivators and livestock farmers are increasingly arranging innovative technical and scientific estimations with the aim to enhance agricultural sustainability, effectiveness, and plant health. Innovative farming technologies incorporate biology with smart technology (computers and sensor devices) exchanging information with one another autonomously in a structured farm management system. This book presents reviews on innovative techniques and methodologies to complement conventional plant control and breeding attempts toward enhancing crop yield and production. Reviews covered in this volume include: -Active compounds from pomegranate seeds -Application of Enterococci and their bacteriocins for meat biopreservation -Technological advancement in the detection and identification of plant pathogens -Machine learning for precision agriculture -Use of remote sensing technology and geographic information systems for agriculture and environmental observation The information presented in this volume will provide helpful updates for students, technology experts and professionals in the food security and sustainable agriculture sectors.

Environmental Microbiology: Advanced Research and Multidisciplinary Applications focus on the current research on microorganisms in the environment. Contributions in the volume cover several aspects of applied microbial research, basic research on microbial ecology and molecular genetics. The reader will find a collection of topics with theoretical and practical value, allowing them to connect environmental microbiology to a variety of subjects in life sciences, ecology, and environmental science topics. Advanced topics including biogeochemical cycling, microbial biosensors, bioremediation, application of microbial biofilms in bioremediation, application of microbial surfactants, microbes for mining and metallurgical operations, valorization of waste, and biodegradation of aromatic waste, microbial communication, nutrient cycling and biotransformation are also covered. The content is designed for advanced undergraduate students, graduate students, and environmental professionals, with a comprehensive and up-to-date discussion of environmental microbiology as a discipline that has greatly expanded in scope and interest over the past several decades.