This volume is a comprehensive compilation of contributions on the state of art knowledge about bioactive compounds including their sources, isolation methods, biological effects, health benefits and potential applications. These bioactive compounds could serve as alternatives in the prevention or treatment of multifactorial diseases for vulnerable population groups. Chapters in the book incorporate the knowledge based on traditional medicine with recent findings on bioactive molecules and their pharmaceutical implications in neurodegenerative diseases, cancer, COVID 19, diabetes, immunomodulation and farm animal diseases. The book also highlights the latest breakthroughs in the field of screening, characterization, and novel applications of natural bioactive compounds from diverse group of organisms ranging from bacteria, algae, fungi, higher plants, and marine sources. Authors from renowned institutions of India, Japan and China have shared their expertise in the contributed chapters with the goal of enhancing readers' knowledge about the significance of use of bioactives in therapeutics and nutraceuticals. It is an informative reference for researchers, professors, graduate students, science enthusiasts, and all those who wish to gain insights into various aspects of bioactive compounds and development of new pharmacological active constituents and nutritional science.

This reference describes the chemistry of organocalcium compounds that contain a Ca-C σ-bond. It collects the information about this niche group of organometallic compounds into 4 easy-to-read chapters. It is intended for scholars in the field of organic chemistry, and researchers in industrial chemistry and chemical engineering departments. Key features: - Presents a comparison to homologous compounds of other alkaline earth metals. - Explains the main problems encountered in the synthesis of organocalcium compounds with reference to the reactivity of calcium, the low solubility in common solvents and the high reactivity of the formed intermediates and products - Highlights many concepts about the Ca-C bond such as the steric hindrance, degrading agent properties, organocalcium spectroscopy, and more

Frontiers in Medicinal Chemistry is a book series devoted to reviews on research topics relevant to medicinal chemistry and allied disciplines. Frontiers in Medicinal Chemistry covers developments in rational drug design, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, chemoinformatics, and structure-activity relationships. This book series is essential for any medicinal chemist who wishes to be updated on the latest and the most important advances in the field. This is the tenth volume of the series. The extensive volume brings 11 reviews on a variety of topics including anti-cancer drug therapeutics, food chemistry, toxicology and drug development strategies. The list of topics in this volume includes: Isoxazole derivatives as potential pharmacophore for new drug development Contemporary trends in drug repurposing: identifying new targets for existing drugs Pharmaceutical potential of pyrimidines as antiviral agents Drugs and phytochemicals targeting cancer Harnessing the neurological properties of indian brain health booster brahmi Carcinogenicity of hexavalent chromium and its effects Medicinal plants: a future of modern medical system Shikonin, a naphthaquinone of commercial importance: its biosynthesis and prospect for use as drugs Fast foods: chemical composition and implications for health Implications of DNA-acting agents as anticarcinogenic potential in breast cancer therapeutics Aloe vera - a medicinal plant as potential therapeutic agents for liver cancer

Explore the fascinating interplay between chemical elements and biological life with Biological and Medical Significance of Chemical Elements. This comprehensive handbook delves into the pivotal role that various chemical elements from the periodic table play in the intricate web of life processes. Discover how these elements impact human health, influence drug development, and contribute to essential biological pathways. Key Features: - Provides information on the occurrence and classification of chemical elements in nature - Explains the biological functions of elements from different main groups (including s-, p-, d- and f-block elements) - Includes information about the biomedical significance of platinum metals, lanthanides, and actinides - Includes a list of references for further reading This book serves as an indispensable resource for anyone interested in the medical biochemistry of chemical elements.

Medicinal chemists around the world have been inspired by nature and have successfully extracted chemicals from plants. Research on enzymatic modifications of naturally occurring compounds has played a critical role in the search for biologically active molecules to treat diseases. This book explores compounds of interest to researchers and clinicians. It presents a comprehensive analysis about the medicinal chemistry (drug design, structure-activity relationships, permeability data, cytotoxicity, appropriate statistical procedures, molecular modelling studies) of different compounds. Each chapter brings contributions from known scientists explaining experimental results which can be translated into clinical practice. Each chapter follows a specific format for a phytochemical agent with common chemical features: - General background on the (phyto)chemistry of the scaffold - General background on the pharmacological profile of the scaffold - A Description of the proposed derivatives and their advantages with respect to the parent compounds (emphasizing the synthetic approaches and structure-activity relationships) - In silico analysis of the crucial interactions with the biological target - Clinical studies and patent survey (if available) on the new and proposed structures The objective of this book set is to fulfil gaps in currently acquired knowledge with information from the recent years. It serves as a guide for academic and professional researchers and clinicians.

This book informs readers about recent advances in graphene carbocatalysis encapsulating the current developments in the syntheses, properties, characterizations, functionalization and catalytic applications of graphene, its derivatives and composites. It serves as a comprehensive primary reference book for chemistry and engineering students who are required to learn about graphene chemistry in detail. It also serves as an introductory reference for industry professionals and researchers who are interested in graphene research as well as its emerging applications in catalysis and beyond. Volume 2 presents information about the industrial applications of graphene-based materials. It starts with graphene-based photocatalysis and progresses into the electrochemical applications of related materials. Highlighted applications in this domain include the use of graphene for hydrogen production and in electrodes for electrochemical sensors. It also covers developments in graphene-based smart energy materials. The final chapter of the volume summarizes the future of graphene-based material technology.

This book informs readers about recent advances in graphene carbocatalysis encapsulating the current developments in the syntheses, properties, characterizations, functionalization and catalytic applications of graphene, its derivatives and composites. It serves as a comprehensive primary reference book for chemistry and engineering students who are required to learn about graphene chemistry in detail. It also serves as an introductory reference for industry professionals and researchers who are interested in graphene research as well as its emerging applications in catalysis and beyond. Volume 1 provides an introduction to catalysis and the chemistry of graphene. This is followed by chapters that cover the chemistry of graphene compounds. Next, it covers the functionalization of graphene into catalytic materials and its role in the synthesis of nanocomposites. Finally, the book delves into the complex aspects of graphene carbocatalysis: recent advances in graphene supported palladium catalysts for coupling reactions, applications of graphene-based catalysts in multicomponent, domino reactions, oxidation and reduction reactions, and recent trends in biocatalytic properties of graphene-based composites are all discussed in detail.

This book introduces readers to the fundamentals of oxygen atom transfer reactions. It also gives mechanistic insights into the redox processes occurring through the oxygen atom transfer reactions. It also includes information about catalytic activation of oxygen through enzymes and oxo-metallic complexes. All topics are explored in separate chapters. Key features: - reviews the basic mechanisms in redox processes involving oxo-atom transfer reactions. - presents progress in the biomimetic activation of dioxygen related to the catalytic oxidations by synthetic metal organic complexes. - covers an important class of metal-organic compounds - nickel-oxygen species - generated in catalytic oxidation processes as oxygen atom transfer agents. - explains the mechanistic aspects of the heterogeneous photochemical redox processes via oxo-atom transfer reactions - provides references for further reading It is a reference for both professional scientists in the fields of chemistry, biology and applied sciences, and for graduate and undergraduate students interested in understanding reaction mechanisms involving oxygen.

Bentham Briefs in Biomedicine and Pharmacotherapy showcases the latest developments and techniques in the fields of pharmacology and healthcare, presenting them in distinctive volumes. Each volume offers a concise, focused overview of subjects, authored by experts in the field. The book series serves as an anthology for graduate students and researchers in pharmacology and life sciences, as well as medical professionals seeking specialization for research-related projects. The second volume, Botanicals and Natural Bioactives: Prevention and Treatment of Diseases, discusses the medicinal applications of natural bioactives in the treatment of a variety of physiological disorders, including cardiovascular diseases, neurological dysfunctions, infectious diseases, age-related diseases, and cancer. The volume has eight chapters on disease treatment and preventative measures, with contributions from more than twenty experts. Readers will comprehend the niche utilization of botanicals and natural bioactives as medicinal agents for a variety of ailments. Overall, the chapters dwell on the chemosensory features of nutritious foods to avoid non-communicable diseases and the role of immunomodulating natural products and botanicals in the prevention and treatment of skin diseases, aging, inflammation, cancer, parasitic infections in the bloodstream, neurodegenerative diseases, osteoporosis, coronary heart disease, and autoimmune disorders. The variety of topics covered in this book makes it an excellent resource for a wide audience interested in phytomedicine.

This book explores a revolutionary sensing technique called Indicator Displacement Assays (IDAs). It is designed to provide readers with a comprehensive understanding of the conceptual foundation and wide-ranging applications of IDAs. The book aims to fulfill a crucial gap in the existing references on the subject. The content starts by explaining fundamental concepts, design strategies, and the scope of IDAs. Subsequent chapters elaborate on the intricate molecular recognition of various analytes, offering insights into sensing mechanisms for cationic, anionic, and neutral molecules. The design and construction of colorimetric, fluorescence, and metal complexing IDAs are also thoroughly explored in later chapters, followed by recent extensions of IDAs, including enantioselective indicator displacement assays, intramolecular indicator displacement assays, reaction-based indicator displacement assays, and more. Innovative applications of IDAs, such as sensory arrays and electrochemical sensors, are also discussed in detail, providing a comprehensive understanding of their conceptual foundations and practical implementations. The book is a primer on IDAs for researchers who want to understand the fundamentals of the technique, as well as postgraduate students aiming to specialize in supramolecular and analytical chemistry.