The main theme of this book is to critically survey the role of two recognized protein molecules (i.e., transcription factors) in processes of human memory. In addition, authors provided recent data from their own labs and provided a perspective relevant to specific neurological diseases and potential drug targets. Historically, the transcription factor cAMP response element-binding (CREB) has been the most well documented transcription factor shown to play a role in memory. CREB has several functions, but its most notable function has to do with the formation of long-term memories. More recently, other transcription factors, such as C/EBP, Egr protein, AP-1, and NF-κB have been implicated in memory as well. Of these, scientific literature on NF-κB’s theorized role in synaptic plasticity and memory is growing rapidly. Interestingly, in some recent studies CREB and NF-κB have also been shown to interact with each other where both contribute in a cooperative fashion to the initiation of gene expression.

Nanotechnology has revolutionized cancer diagnosis and therapy through targeted drug delivery. Advances in protein engineering and materials science have led to the development of nanocarriers (NCs), which have helped overcome the challenges faced during conventional cancer treatment. These nanocarriers serve as an efficient transport module for drugs. Nano-drug delivery has emerged as a promising technology that results in early detection and better treatment of various cancers. The approved nanoparticles currently used in cancer treatment strategies include liposomes, dendrimers, polyplexes, solid lipid nano-carriers, etc. These nanocarriers shall provide a quick, safe, and cost-effective method in cancer therapy and management. This book contains thirteen chapters focusing on the treatment of various cancers, i.e., lung, breast, cervical, ovarian, colon, prostate, head and neck, etc., through nanocarrier drugs. The chapters include reviews on a wide variety of advanced data from existing and ongoing clinical research and major regulatory considerations. This reference book will greatly benefit undergraduate and postgraduate students, oncologists, pharmacists, and researchers involved in nanomedicine and nano-drug delivery.

This textbook presents the latest information and techniques in pediatric dentistry. The chapters cover primary pediatric dentistry, its clinical aspects, preventive dentistry, and information about the latest trends in the specialty. The text will equip readers with the knowledge suited to the changing environment of this vital domain. This textbook's editor has over forty-four years of teaching experience in pediatric dentistry and gives a broad perspective through the book content. This book is also an amalgamation of the knowledge brought forth by numerous subject experts of international repute. Part 4 covers specialized topics for clinical practice that professionals need to understand. The book covers drugs in pediatric dentistry, anesthesia, dental surgery, implants and lasers. Special topics like the management of special needs children and HIV/AIDs patients, new advances and genetics are also covered in this part. Key Features: - The 16, structured chapters keep the latest trends of the subject in mind - The book content is illustrated with quality clinical images - Chapters cover contemporary concepts of problems experienced when treating multiple dental disorders - The contributions exhibit distinct clinical expertise and the capability of imparting inimitable knowledge to budding professionals - The book includes state-of-the-art techniques used in the clinic Topic outlines help to quickly review and easily locate content. Also, the Contents of the book are well structured and presented in a very lucid manner, making it easy to understand for students.

Illustrated Pediatric Dentistry is intended to be a guide to undergraduate and postgraduate students in their understanding of pediatric dentistry. This textbook is modernized with the latest information and techniques in pediatric dentistry. The chapters cover primary pediatric dentistry, its clinical aspects, preventive dentistry, and information about the latest trends in the specialty. The text will equip readers with the knowledge suited to the changing environment of this vital domain. This textbook's editor has over forty-four years of teaching experience in pediatric dentistry and gives their broad perspective through the book content. This book is also the amalgamation of the thoughts of numerous subject experts of international repute. Part 1 of this book features information about the developmental psychology of a child, dental caries, craniofacial growth and development, growth of the maxilla and mandible, dentition and occlusion, and oral mucosa. Key Features: - The 15, structured chapters keep the latest trends of the subject in mind - The book content is illustrated with quality clinical images, - Chapters cover contemporary concepts of problems experienced when treating multiple dental disorders - The contributions exhibit distinct clinical expertise and the capability of imparting inimitable knowledge to budding professionals - The book includes modern and current state-of-the-art techniques used in the clinic - Topic outlines help to quickly review and easily locate content. Also, the Contents of the book are well structured and presented in a very lucid manner, making it easy to understand for students.

Illustrated Pediatric Dentistry is intended to be a text book for enhancing the knowledge and understanding of paediatric dentistry amongst undergraduate and postgraduate students. This textbook is updated with the latest information on techniques employed in paediatric dentistry. Chapters in this part cover primary paediatric dentistry, its clinical aspects, preventive dentistry, and information about the latest trends prevalent in this specialty field of dentistry. The text will equip readers with the knowledge suited to the changing environment of this vital domain. The editor of this textbook has over forty-four years of teaching experience in paediatric dentistry and is able to successfully impart a broad perspective of the subject through the book’s contents. This textbook is the amalgamation of the experience and knowledge of various subject experts that command a high international reputation. Part 2 covers orofacial swelling, pediatric space management, interceptive orthodontics and myofunctional therapy, gingival and periodontal diseases, oral hygiene, minimum intervention dentistry (MID), molar incisor hypoplasia (MIH), restorative dentistry, and oral examination and diagnostic aids used in pediatric dentistry. Key Features: - The 15, structured chapters present the latest trends in paediatric dentistry - The book content is illustrated with quality clinical images, - Chapters cover contemporary concepts of problems experienced when treating multiple dental disorders in young patients - Contributions from subject experts present distinct clinical expertise and a unique style of imparting important current knowledge to budding professionals - The book includes modern and current state-of-the-art techniques used in the clinic - Topic outlines throughout the book will greatly help readers to quickly locate and review the content. Contents of the book are very well structured and presented in a lucid manner, making it easy to understand.

Illustrated Pediatric Dentistry is intended to be a guide to undergraduate and postgraduate students in their understanding of pediatric dentistry. This textbook is modernized with the latest information and techniques in pediatric dentistry. The chapters cover primary pediatric dentistry, its clinical aspects, preventive dentistry, and information about the latest trends in the specialty. The text will equip readers with the knowledge suited to the changing environment of this vital domain. This textbook's editor has over forty-four years of teaching experience in pediatric dentistry and gives their broad perspective through the book content. This book is also the amalgamation of the thoughts of numerous subject experts of international repute. Part 3 covers several topics relevant to practical dentistry such as, pediatric crowns, prosthetic management, pental pulp, pediatric endodontics, (including regenerative medicine and instruments), traumatic dental injuries, sports dentistry, Systemic Fluorides, (like SDF) and pit and fissure sealants. Special topics like fental caries vaccine and post-COVID dental practice round up this book. Key Features: - The 18, structured chapters keep the latest trends of the subject in mind - The book content is illustrated with quality clinical images, - Chapters cover contemporary concepts of problems experienced when treating multiple dental disorders - The contributions exhibit distinct clinical expertise and the capability of imparting inimitable knowledge to budding professionals - The book includes modern and current state-of-the-art techniques used in the clinic Topic outlines help to quickly review and easily locate content. Also, the Contents of the book are well structured and presented in a very lucid manner, making it easy to understand for students.

An Epidemiological Update on COVID-19 brings recent findings about the pandemic to the forefront. The reference is a compilation of eleven chapters contributed by expert scholars in epidemiology and medicine that cover topics of interest to anyone interested in COVID-19 monitoring and response measures. The topics also indicate some clinical areas of interest to COVID-19 researchers that have received attention due to the pandemic. It covers basic knowledge about respiratory conditions associated with SARS-CoV-2 infection and COVID-19 epidemiology. These topics are complemented with chapters detailing the symptoms and biochemical mechanisms of novel coronavirus infections intended for readers with an advanced level of understanding of life sciences and medicine. Special topics such as the immune response to Sars-CoV-2, and, recombinant drugs for COVID-19, are also covered in this book. Each chapter is organized in a reader-friendly format and includes a list of references.

This update on SARS-CoV-2 focuses on basic knowledge about the virus and COVID-19 treatment. Chapters present basic information about the disease and its treatment. The virology, epidemiology, etiology, and damage response framework of SARS-CoV-2 are also discussed in detail. The book also covers recent topics of interest to pharmacology scholars such as the immunopathogenesis of SARS-CoV2, nanotechnology, repurposed drug treatments, COVID-19 vaccines, and phytomedicine for COVID-19 therapeutics. Readers in pharmacology, virology and medicine will find the book a simple, yet informative update on SARS-CoV-2 and COVID-19 treatment.

Type 2 diabetes (T2D) is a complex metabolic disorder characterized by impaired glucose metabolism and pancreatic β-cell dysfunction. No effective treatments are available for T2D, although there have been many developments in the therapeutic arena. Nitric oxide (NO) is an endocrine agent with multiple and important biological roles in most mammalian tissues. NO has emerged as a central regulator of energy metabolism and body composition. NO bioavailability is decreased in T2D. Several of the pharmaceuticals used in T2D affect the NO system and perhaps even more so by the drugs we use to treat diabetic cardiovascular complications. Experimental works in animal models of T2D show promising results with interventions aimed to increase NO signaling. However, translation into human studies has so far been less successful, but more large-scale prolonged studies are clearly needed to understand its role. This book is a collection of reviews that deal with the role of nitric oxide in type 2 diabetes, providing a unique overview of NO signaling, and pointing out key areas for more detailed research. The book includes contributions about the pathophysiology of T2D, a brief history of discovery and timeline of NO research, a comprehensive overview of impaired NO metabolism in T2D, precursors of NO (i.e., L-arginine, L-citrulline, nitrate, nitrites, and NO donors), NO and T2D from genetic points of view, NO and diabetic wound healing, NO and osteoporosis, NO and hyperuricemia, NO and Alzheimer's Disease, therapeutic applications of NO and NO donors in T2D. The compilation is of great value to anyone interested in the biochemistry of NO and its relationship to diabetes.

This comprehensive reference is a timely exploration of two vital aspects of triple-negative breast cancer. The book offers a holistic perspective that helps readers to navigate the challenges of managing triple-negative breast cancer (TNBC) with knowledge and confidence. Understanding Ethnic Disparities and Targeted Therapies: This section provides a critical overview of the ethnic disparities and the latest targeted therapies available for patients facing advanced or metastatic triple-negative breast cancer (TNBC). Empowering Patients and Enhancing Communication: This section dives into the essential role of patient education, empowerment, effective communication with medical teams, and psychological or supportive approaches, providing invaluable insights into managing advanced or metastatic breast cancer (BC). Key Features: Introduces a groundbreaking perspective on the TNBC journey, encouraging patients to view their battle with the disease as an opportunity to leverage modern pharmacological advancements and psychological support for improved outcomes. Bridges the gap between clinical or research-related aspects of BC management and the personal needs and expectations of patients, promoting a more holistic approach. Invites perspectives from a wide range of medical professionals, from oncologists and cardiologists to psychologists and nurses, to engage in open dialogues with patients, offering practical education and crucial support. Provides a wealth of helpful resources (including an appendix) for both patients and their medical caregivers, fostering a comprehensive and supportive approach to managing TNBC. This book is an informative resource for medical professionals, researchers, and patients, who want to understand the complexities of triple-negative breast cancer and apply current knowledge in their clinical and caregiving practice.