Abstract
Alzheimer’s disease is the most common neurodegenerative disease. Despite intensive research, promising therapies have failed to translate to the clinic. This chapter will review the prevailing mechanistic hypotheses to explain AD pathogenesis, including the cholinergic, amyloid-cascade, inflammatory and metal dyshomeostasis theories, present an update on the clinical developments in therapies targeting each of the hypotheses, and highlight promising areas requiring further research.
Keywords: Alzheimer’s disease, Amyloid antibodies, Amyloid cascade hypothesis, Cholinergic hypothesis, Clinical trials, COX inhibitors, Familial, Metal homeostasis, Metal ionophores, Multi-targeting, Neuroinflammation, Secretase modulators, Sporadic.
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