Synthesis of Organic Molecules Using Hydrotalcite Based Materials

Abstract

Hydrotalcites (HTs) belong to layer double hydroxide (LDH) structure and are the anionic clays that contain a double-layered structure similar to brucite [Mg (OH)2 ]. The layering structure allows the intercalation with a variety of anionic species, oxometallates, and palmitoleates including absorbed water in the interlayer as well as on the surface. Hydrotalcites (HTs) are the high-performance solid catalysts for the one-pot synthesis of organic compounds in the industry as well as the laboratory by the various chemical transformations such as Claisen-Schmid, aldol, Knoevenagel condensations, and Michael addition, isomerization, and Friedel-Craft alkylation owing to their surface Lewis base catalyst. This chapter offers an exposition on the diverse strategies employed for crafting various organic scaffolds by using Hydrotalcites as a catalyst and their applications within the spheres of biomedical and pharmaceutical industries.

Keywords: Aldol condensations, Alkylation, Claisen–Schmidt condensations, Coupling reactions, Catalyst, Double layer, Deoxygenation, Epoxidation, Hydrogenolysis, Hydrotalcites and Knoevenagel Michael additions.