Interplay between Diabetes and Breast Cancer: A Brief Report

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Abstract

Cancer and diabetes are two of the most prevalent and complicated diseases. Several epidemiological studies have found a link between type 2 diabetes and an increased risk of breast cancer. This chapter aims to highlight the advances in understanding the mechanisms that connect diabetes and breast cancer. Alterations in glucose metabolism, hyperinsulinemia, insulin resistance, changes in the hormonal environment, and substrate availability create a metabolic environment that is particularly favourable for the growth of tumours. Therefore, it is vital to understand the correlation between diabetes mellitus and breast cancer. A precise analysis of these relationships could help in finding biomarkers that can predict disease risk and prognosis, and aid in selecting appropriate, evidence-based diagnostic and therapeutic approaches

Keywords: Breast cancer, Hyperlipidemia, Insulin resistance, Inflammatory cytokines, RAGEs, Signalling pathway, Type 2 diabetes.

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