Precision Medicine in Fibromyalgia Syndrome

Individualized remedy for patients is a middle objective of today’s clinical approach and the need of our society. Many elements, starting from genes to proteins, all stay unknown for their unique roles in human physiology. The accurate prognosis, monitoring, and remedy of various problems require dependable biomarkers, for the development of correct healing interventions. Precision medicine within the treatment of Fibromyalgia Syndrome (FMS) has attracted a whole lot of attention, particularly with the gene discovery pushing toward more modern know-how of the biology of disorders. Genome-huge association research has proven that in fibromyalgia pathogenesis, genetic factors are accountable for as much as 50% of the sickness susceptibility. Candidate genes determined to be associated with fibromyalgia are SLC64A4, TRPV2, MYT1L, and NRXN3. Fibromyalgia is an extensive musculoskeletal pain disorder followed by fatigue, sleep, memory, and mood troubles.

 Fibromyalgia syndrome (FMS) exacerbates painful sensations by altering the way the brain and spinal cord process both painful and non-painful signals. While some targeted treatments have shown promise in improving the condition of FMS patients in the short term, there is an opportunity to delve deeper into the mechanisms at play. With the aid of animal models, we can further explore the intricate interplay between the brain and the spinal cord, identifying specific genes, loci, and potential failures within the spinal cord that contribute to FMS.

Additionally, FMS has been linked to biogenic amine depletion and mitochondrial dysfunction. These factors represent crucial avenues for investigation. This chapter aims to spotlight the significant advancements in technology that facilitate personalized or precision medicine approaches for FMS. Since FMS is closely tied to the functioning of the brain and spinal cord, research using animal models offers a promising avenue, as conducting experiments on patients presents logistical challenges. 

Keywords: Animal model, Anxiety disorders, Amine depletion, Fibromyalgia prognosis, Precipitated fibromyalgia, Sleep aetiology.