Natural Dentin Biomodifiers

Nowadays, researchers are interested in using extracts from natural sources as medicines or health-promoting agents. Herbs and natural sources with medicinal properties are beneficial for treating oral diseases. Dentistry uses natural products as antimicrobial, anti-inflammatory, and sedative agents. Various physical and chemical factors, including hydrolysis and enzymatic degradation by matrix metalloproteinases (MMPs) derived from the host, degrade bonding over time. Recent biomodifications to dentin have produced a more stable and resilient adhesive contact. It has been determined that plant-derived natural cross-linkers are effective at enhancing the mechanical properties of dentin and controlling its biodegradation by inhibiting proteases. Dentin biomodification by these naturally derived cross-linking agents has remarkable effects on caries prevention and dentin remineralization, which is even more extraordinary. Natural bio-modifiers are naturally occurring substances whose potential dental applications have garnered increased attention in recent years. Compared to synthetic agents, the most appealing characteristics of biomodifiers and renewable/sustainable resources are their minimal toxicity and renewable/sustainable nature. Natural proanthocyanidins (PACs) taken from different natural sources have a high ability to cross-link with collagen. This makes the organic matrix of dentin more biostable and stronger.

Keywords: Anthocyanin, Cardol, Catechin, Chlorhexidine, Collagen, Cranberry, Cross-linker, Cysteine cathepsins, Dentin biomodifiers, Flavonoids, Genipin, Glutaraldehyde, Lycopene, MMP, Polyphenol, Proanthocyanidins, Propolis, Quercetin, Tannin, Theobromine.