Forecasting the Parallel Interaction between Biosurfactants and Neurons: A Challenge for Clinicians

Bacteria that are associated with human health are receiving a growing amount of attention, particularly those that inhabit the body's niches, such as the neural stem, neurons, gastrointestinal tract, skin, vaginal environment, and lungs. Biosurfactants are molecules that are both hydrophobic and hydrophilic, and receive little attention among the secondary metabolites that are released by microorganisms that are associated with human health. Not only do they serve as biosurfactants, but they also have the potential to control the microbiota through their antimicrobial activity and quorum sensing system in the complex human environment. They and the human body as a whole are shielded from microbial and fungal pathogens by these functions. Because of their diverse structures, biological functions, low toxicity, higher biodegradability, and adaptability, biosurfactants are now emerging as promising bioactive molecules. As a result, biosurfactants with antimicrobial activity, which are produced by bacteria that are associated with the human body and are related to everything that humans come into contact with, such as food, beverages, and comestics, are the subject of this comprehensive review.

Keywords: Blood brain barrier, Cytotoxic, Cancer therapy, Neurons, Rhamnolipid.