Acne and Current Possible Treatments

Acne vulgaris is one of the most skin diseases related to the sebaceous gland, characterized by multiple pathogenic factors. The treatment strategies involve the blockage of these pathological factors. Conventional therapies for the treatment of Acne vulgaris in controlling its pathological factors are still inadequate in providing therapeutic effectiveness and exhibit remarkable side effects. New therapeutic agent development for acne treatment is still stagnant. Recently, researchers have been focusing and seeking great interest in the treatment of acne through natural products – as a new therapeutic option. In this regard, multiple natural products have been evaluated for their potential to treat acne, including berberine, α-mangostin, curcumin, ampelopsin, fustin, ellagic acid, gallic acid, myricetin, lupeol and many more. These natural products have been reported as suitable candidates for blocking multiple pathogenic factors associated with acne. In addition, the nanotechnology-based delivery of natural products is a new platform and treatment option for Acne vulgaris. Natural products nano-based delivery resolves many other issues concerned with natural products apart from treatment aid. Natural products, therefore, pose a precious source in determining new agents for the treatment of acne. However, reported studies are preclinical, and to obtain reliable and conclusive results, further clinical studies are required to uplift natural products from bench top to clinical setup in treating the worst consequences of Acne vulgaris. 

Keywords: Acne, Pathological factors, Treatment, Natural products, Nano-delivery.