Recent Development and Advancement in Microneedle-Assisted Drug Delivery System Used in the Treatment of Cancer

Cancer is one of the most common and distressing diseases. Cancer-related mortality and prevalence have both grown in the last 50 years. Due to its intricacy and progressive nature, cancer remains one of the most debilitating diseases in humans, and clinical care for this lethal disease remains a challenge in the twenty-first century. New and better cancer medicines are constantly needed. Due to the rising global incidence of cancer, the development of novel alternatives to traditional medicines is unavoidable to overcome constraints, such as limited efficacy, comorbidities and high cost. Microneedle arrays (MNs) have just been introduced as an innovative, low-cost, and minimally invasive technique. MNs can safely and precisely deliver micromolecular and macromolecular pharmaceuticals, as well as nanoparticles (NPs), to tumor tissue. However, only a few lipophilic pharmacological compounds with low molecular weight and a rational Log P value were able to pass the skin barrier. Microneedles (MNs) can circumvent these constraints by piercing the body's outermost skin layer and delivering a variety of medications into the dermal layer. MN patches have been made with a variety of materials and application methods. Recently, three-dimensional (3D) printing “A touch button approach” gives the prototyping and manufacturing methods the flexibility to produce the MN patches in a one-step manner with high levels of shape complexity and duplicability. 

Keywords: Additive Manufacturing, Anticancer Therapy, Cancer, Dosage Form, Evaluation Parameters, Structure of Skin, Fabrication, Material, Method, Microneedle Arrays, Microneedle Drug Delivery System, Novel Drug Delivery, On-demand Manufacturing, Three-dimensional Technology, Transdermal Drug Delivery System, Transdermal Enhancement Techniques, Patient-centric Formulation, Personalized Medicine, Pharmaceutical Printing, Target Therapy.