Abstract
Concerns regarding possible toxicological effects on human health and the
environment have arisen as nanomaterials (NMs) result from various substances that
have become more widely used in various sectors mainly industry, environment, and
medicine. This chapter provides a thorough examination of nanotoxicology and
nanosafety approaches concerning NMs upon their development and subsequent
implementations. The importance of emerging toxicological strategies developed over
the last few decades for the evaluation of NMs toxicity including cell culture studies (in
vitro), living organisms (in vivo), and computational methods (in silico) following the
advantages/disadvantages of each technique is addressed. A comprehensive overview
to reduce the NMs toxicity and the most common approaches adopted up to now
mostly focused on medical considerations are also presented here.
Keywords: Computational approaches, In silico, In vitro, In vivo, Nanomaterials.
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