“Fit for Purpose” 64Cu Labeled Liposome Formulations Specialized for Enriched Targeting to 1) Bone Marrow Spleen; 2) lymph Nodes; or 3) Tumor

Pp: 272-276 (5)

* (Excluding Mailing and Handling)

Upon intravenous injection, liposomal particles are rapidly cleared from the

blood by fixed macrophages in the liver, spleen, bone marrow and lymph nodes i.e.

specialized cells of the innate immune system. By reducing the affinity for these fixed

macrophages, therapeutic liposomes containing drugs have been used to target tumor

by the Enhanced Permeability and Retention (EPR) effect. In this communication, we

report minor modifications of lipid compositions that result in the production of 3

classes of liposomes, each suitable for enhanced selectivity of uptake in 1) Bone

Marrow/Spleen (SBMT Lipo); 2) Lymph Nodes (LNT Lipo); and 3) Tumor (TT Lipo).

Keywords: Bone Marrow Imaging, Copper-64, Endothelial Macrophages, Lymph Node Imaging, Nanoparticles, PET, Reticuloendothelial System, Tumor Imaging.

Cite as

Current Dentistry

Current Psychopharmacology

Recent Advances in Anti-Infective Drug Discovery

Anti-Infective Agents

Adolescent Psychiatry

Current Alzheimer Research

Current Aging Science

Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Current Diabetes Reviews

Current HIV Research

Andrology: Current and Future Developments

Male Infertility: An Integrative Manual of Western and Chinese Medicine

Awake Thoracic Surgery

The Anatomical Foundations of Regional Anesthesia and Acute Pain Medicine Macroanatomy Microanatomy Sonoanatomy Functional anatomy

Frontiers in Anti-infective Agents

The Evolution of Radionanotargeting towards Clinical Precision Oncology: A Festschrift in Honor of Kalevi Kairemo