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Review Article

克隆造血中的靶向免疫信号通路

卷 26, 期 28, 2019

页: [5262 - 5277] 页: 16

弟呕挨: 10.2174/0929867326666190325100636

价格: $65

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摘要

背景：髓样肿瘤是由各种恶性疾病组成的，具有不同的实体和众多的病理临床特征。它们来自造血干细胞和祖细胞的突变克隆，这些克隆的表现优于正常人。癌细胞的细胞内信号传导特征是遗传，表观遗传和微环境影响的总和，不同信号传导途径之间的多重相互联系使药理靶向变得复杂。 目的：概述骨髓增生性肿瘤（MPN），骨髓增生异常综合征（MDS）和急性髓细胞性白血病（AML）的已知体细胞突变，以及受其影响的炎性信号通路，以及目前在治疗上调节这种异常炎性信号的努力。 方法：在本次审查中，我们使用重点审查问题，以ClinicalTrials.gov作为我们正在进行的研究的来源，以PubMed作为我们的真实书目来源来广泛审查和汇编重要信息。 结果：影响免疫信号转导的突变在克隆性骨髓疾病中以不同程度存在。尽管MPN受到一些常见突变的支配，但MDS和AML中可以突变许多不同的基因。无症状者也可能发生突变，这一发现被称为潜在不确定性克隆性造血（CHIP）。 FLT3，JAK，STAT，CBL和RAS中的突变可导致异常的免疫信号传导。蛋白激酶抑制剂正在进入临床，并在MPN，MDS和AML的临床试验中进行了广泛研究。 结论：总而言之，本文总结了近期在克隆性髓样疾病中炎性信号传导的研究以及在受影响途径中调节信号转导和效应蛋白的临床治疗潜力。

关键词: 克隆性造血，MPN，MDS，MDS / MPN-RS-T，AML，炎症，免疫信号通路，靶向。

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