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Review Article

瞄准脑中的水：水通道蛋白-4在缺血性脑水肿中的作用

卷 20, 期 7, 2019

页: [748 - 755] 页: 8

弟呕挨: 10.2174/1389450120666190214115309

价格: $65

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摘要

脑水肿主要是由于各种脑损伤（包括缺血性中风）引起的。 脑水含量的过度积累导致脑实质的逐渐扩张，血流量减少和颅内压增加，最终导致脑疝和死亡。 目前对缺血性水肿的临床治疗非常有限，因此迫切需要开发新的治疗策略。 越来越多的证据表明，AQP4是一种水通道蛋白，与脑水肿密切相关，可能是减少缺血性脑水肿的最佳治疗靶点。 AQP4主要分布在中枢神经系统中，主要调节正常和病理条件下脑细胞的水通量。 本综述重点介绍AQP4与其在水肿形成和消除中的双重作用相关的潜在机制。

关键词: 水通道蛋白-4，脑水肿，中枢神经系统，中风，治疗目标，水通道。

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