Regulation of T cell Apoptosis during the Immune Response

Title: Regulation of T cell Apoptosis during the Immune Response

Volume: 2 Issue: 3

Author(s): Sven Baumann, Andreas Krueger, Sabine Kirchhoff and Peter H. Krammer

Affiliation:

Keywords: T cell Apoptosis, Immune Response, CD95 SIGNALING PATHWAY, THYMOCYTE SELECTION, DEATH RECEPTORS, Death domain, FLICE inhibitory protein

Abstract: Apoptosis of T-lymphocytes is a fundamental process regulating antigen receptor repertoire selection during T cell maturation and homeostasis of the immune system. It also plays a key role in elimination of autoreactive lymphocytes. Resting mature T cells are activated by antigen to elicit an appropriate immune response. In contrast, preactivated T cells undergo activation-induced cell death (AICD) in response to TCR triggering alone. Thus, death by apoptosis is essential for function, growth and differentiation of T-lymphocytes. This review focuses on apoptosis mechanisms involved in T cell development and during the course of an immune response.

Cite this article as:

Baumann Sven, Krueger Andreas, Kirchhoff Sabine and Krammer H. Peter, Regulation of T cell Apoptosis during the Immune Response, Current Molecular Medicine 2002; 2 (3) . https://dx.doi.org/10.2174/1566524024605671