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Review Article

可逆性：具有细胞脱分化剂和选择性抗癌药双重活性的合成嘌呤。

卷 27, 期 21, 2020

页: [3448 - 3462] 页: 15

弟呕挨: 10.2174/0929867326666190103120725

价格: $65

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摘要

数十年来，成年和胚胎干细胞新的治疗应用的发展一直主导着再生医学和组织工程。然而，自2006年以来，诱导多能干细胞（iPSC）已成为该领域的中心问题，因为它们有望克服其他干细胞类型的一些局限性。尽管如此，多年来，甚至在产生iPSC之前，还尝试了其他有前途的成年细胞重编程方法。尤其是在发现iPSC的两年前，合成大型有机化合物库的可能性以及开发高通量筛选以快速测试其生物学活性的可能性，使人们得以鉴定2，6-二取代嘌呤，被称为可逆的，被证明能够将成年细胞重编程为祖细胞样状态。自从发现以来，已经证实了可逆在不同细胞类型上的作用，并且对其作用机理的多项研究表明，它在抑制与细胞周期调控和胞质分裂有关的几种激酶的抑制活性中起着核心作用。这些关键特征及其化学性质表明该分子有可能用作抗癌药。值得注意的是，可逆性药物在体外对几种肿瘤细胞系表现出有效的细胞毒活性，并且在降低体内肿瘤的进展和转移方面具有显著作用。因此，自发现以来已有15年的时间，本综述旨在批判性地总结现有知识，以阐明可逆性作为去分化剂和抗癌药的双重作用。

关键词: 逆转，去分化，重编程，重新定位，抗癌，抗肿瘤药物。

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