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Review Article

细胞衰老与抗癌治疗

卷 20, 期 7, 2019

页: [705 - 715] 页: 11

弟呕挨: 10.2174/1389450120666181217100833

价格: $65

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摘要

背景：细胞衰老通常被理解为由不同原因引起的永久性细胞周期停滞。细胞衰老诱导细胞周期停滞的机制是复杂的，涉及端粒缩短、炎症和细胞应激之间的相互作用。近年来，越来越多的研究表明，细胞衰老可能介导邻近细胞的癌症进展，但这一观点是有争议的，矛盾的证据认为细胞衰老也有助于肿瘤抑制。 目的：鉴于衰老在各种生理和病理情况下的复杂作用，我们试图阐明细胞衰老对肿瘤进展的确切作用。 方法：在大量相关文章中搜索信息，以支持我们的观点。 结果：我们讨论了肿瘤治疗中细胞衰老的相对普遍的发生率，并确定了衰老的阳性和阴性对肿瘤进展的影响。 结论：我们认为促衰老治疗的有效性可以作为一种有希望的治疗癌症疾病的方法，特别是在其他抗癌治疗的不良临床结果方面。

关键词: 细胞衰老，生物标志物，机制，癌症治疗，药物联合，肿瘤抑制。

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图形摘要

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