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Review Article

他汀类药物治疗对胃肠道癌患者生存的影响

卷 20, 期 7, 2019

页: [738 - 747] 页: 10

弟呕挨: 10.2174/1389450120666181211165449

价格: $65

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摘要

他汀类药物是3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）还原酶抑制剂，由于它们对癌细胞代谢的影响，它们可能在癌症的进化中起重要作用。他汀类药物影响几种可能的途径，包括细胞增殖，血管生成，细胞凋亡和转移。评估他汀类药物在癌症中的推定临床益处的试验数量正在增加。目前，全球试验标识符网站clinicaltrials.gov上列出了几项试验。鉴于来自各种临床环境的这些试验的令人信服的证据，有人呼吁在辅助胃肠癌环境中进行他汀类药物的临床试验。然而，与他汀类药物使用相关的特定癌症类型的随机对照试验，以及对没有使用他汀类药物临床适应症的人群的研究，已经阐明了一些潜在的潜在生物学机制，并且可能需要对不同的他汀类药物进行研究。对于这些试验来说，在他们的设计中纳入预测他汀类药物反应的肿瘤生物标志物的评估将是有用的。本综述总结了最近的临床前和临床研究，这些研究评估了他汀类药物在治疗胃肠道癌症中的应用，特别强调了它们与癌症风险的关系。

关键词: 他汀类药物，患者存活，胃肠癌，血管生成，生物学机制，他汀类药物治疗。

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