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Current Medicinal Chemistry

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Review Article

A Review of Drug Repositioning Based Chemical-induced Cell Line Expression Data

Author(s): Fei Wang, Xiujuan Lei and Fang-Xiang Wu*

Volume 27, Issue 32, 2020

Page: [5340 - 5350] Pages: 11

DOI: 10.2174/0929867325666181101115801

Price: $65

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Abstract

Drug repositioning is an important area of biomedical research. The drug repositioning studies have shifted to computational approaches. Large-scale perturbation databases, such as the Connectivity Map and the Library of Integrated Network-Based Cellular Signatures, contain a number of chemical-induced gene expression profiles and provide great opportunities for computational biology and drug repositioning. One reason is that the profiles provided by the Connectivity Map and the Library of Integrated Network-Based Cellular Signatures databases show an overall view of biological mechanism in drugs, diseases and genes. In this article, we provide a review of the two databases and their recent applications in drug repositioning.

Keywords: Drug repositioning, computational biology, bioinformatics, drug candidate, connectivity map, the library of integrated network-based cellular signatures.

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