Generic placeholder image

Current Diabetes Reviews

Editor-in-Chief

ISSN (Print): 1573-3998
ISSN (Online): 1875-6417

Research Article

Pattern and Correlates of Hypomagnesemia Among Subset of Diabetes Mellitus

Author(s): Ihsan Salah Rabeea*, Karrar Al-Gburi, Ihsan Adnan, Bilal Hasan, Massa Mohammed and Mariam Mohammed

Volume 16, Issue 4, 2020

Page: [364 - 369] Pages: 6

DOI: 10.2174/1573399814666181026095236

Price: $65

conference banner
Abstract

Background: Nowadays, there is an accumulated data about the relation between hypomagnesemia (low Serum Mg level < 0.7 mmol/l) and diabetes.

Objective: In this study, we aimed to determine the prevalence of hypomagnesemia in a carefully diagnosed diabetes patients and to show how some factors could contribute to the prevalence of low serum Mg level among the population under study.

Methods: In short, 62 patients of both type 1 and 2, who attended AL-Sadir medical city/ diabetes and endocrinology centre during the period of the study were included in the study. A detailed history was taken and participants were informed verbally about the procedure of this study. Serum magnesium and creatinine were measured using standardized methods.

Results: The overall prevalence of the hypomagnesemia, among diabetic population involved in this study, was 29.03 % and it was nearly similar in male (29.41 %) and female (28.57 %). The means(SD) of serum Mg level were similar in type 1 and type 2 diabetic patients. Other difference in prevalence among other characteristics has been reported. Within all participants, gender (r = -0.02), fasting blood glucose (r = -0.514) and metformin use (r = -0.014) were negatively correlated with serum Mg level, in contrast to other variables, which were positively correlated. While among type 1 DM, age (r= 0.193), serum creatinine (r= 0.031) and insulin use (r= 0.217) were positively correlated with serum Mg level. In contrast, others were negatively correlated. In type 2 DM, age (r = -0.283) and fasting blood glucose (r = -0.496) were negatively correlated with serum Mg level. On the other hand, other variables were positively correlated with serum Mg level.

Conclusion: Hypomagnesemia prevalence was detected in nearly one-third of the diabetic population, which is quite high prevalence. Some factors have shown to play an essential role in this prevalence. A large study is warranted to address this issue.

Keywords: Hypomagnesemia, diabetes mellitus, magnesium ion, patients, metformin, serum creatinine, standard deviation.

[1]
Global Report on Diabetes. WHO Library Cataloguing-in-Publication Data 2016; 978: 88.
[2]
Liamis G, Liberopoulos E, Barkas F, Elisaf M. Diabetes mellitus and electrolyte disorders. World J Clin Cases 2014; 2(10): 488-96.
[http://dx.doi.org/10.12998/wjcc.v2.i10.488] [PMID: 25325058]
[3]
Palmer BF, Clegg DJ. Electrolyte and acid-base disturbances in patients with diabetes mellitus. N Engl J Med 2015; 373(6): 548-59.
[http://dx.doi.org/10.1056/NEJMra1503102] [PMID: 26244308]
[4]
Gröber U, Schmidt J, Kisters K. Magnesium in prevention and therapy. Nutrients 2015; 7(9): 8199-226.
[http://dx.doi.org/10.3390/nu7095388] [PMID: 26404370]
[5]
Kurstjens S, de Baaij JHF, Bouras H, Bindels RJM, Tack CJJ, Hoenderop JGJ. Determinants of hypomagnesemia in patients with type 2 diabetes mellitus. Eur J Endocrinol 2017; 176(1): 11-9.
[http://dx.doi.org/10.1530/EJE-16-0517] [PMID: 27707767]
[6]
Costello RB, Nielsen F. Interpreting magnesium status to enhance clinical care: key indicators. Curr Opin Clin Nutr Metab Care 2017; 20(6): 504-11.
[http://dx.doi.org/10.1097/MCO.0000000000000410] [PMID: 28806179]
[7]
Ramadass S, Basu S, Srinivasan AR. SERUM magnesium levels as an indicator of status of Diabetes Mellitus type 2. Diabetes Metab Syndr 2015; 9(1): 42-5.
[http://dx.doi.org/10.1016/j.dsx.2014.04.024] [PMID: 25470649]
[8]
Jahnen-Dechent W, Ketteler M. Magnesium basics. Clin Kidney J 2012; 5(Suppl. 1): i3-i14.
[http://dx.doi.org/10.1093/ndtplus/sfr163] [PMID: 26069819]
[9]
Kieboom BCT, Ligthart S, Dehghan A, et al. Serum magnesium and the risk of prediabetes: a population-based cohort study. Diabetologia 2017; 60(5): 843-53.
[http://dx.doi.org/10.1007/s00125-017-4224-4] [PMID: 28224192]
[10]
Gommers LMM, Hoenderop JGJ, Bindels RJM, de Baaij JHF. Hypomagnesemia in type 2 diabetes: A vicious circle? Diabetes 2016; 65(1): 3-13.
[http://dx.doi.org/10.2337/db15-1028] [PMID: 26696633]
[11]
Toprak O, Kurt H, Sarı Y, Şarkış C, Us H, Kırık A. Magnesium replacement improves the metabolic profile in obese and pre-diabetic patients with mild-to-moderate chronic kidney disease: A 3-month, randomised, double-blind, placebo-controlled study. Kidney Blood Press Res 2017; 42(1): 33-42.
[http://dx.doi.org/10.1159/000468530] [PMID: 28297698]
[12]
Fang X, Han H, Li M, et al. Dose-response relationship between dietary magnesium intake and risk of type 2 diabetes mellitus: A systematic review and meta-regression analysis of prospective cohort studies. Nutrients 2016; 8(11): 739.
[http://dx.doi.org/10.3390/nu8110739] [PMID: 27869762]
[13]
Hruby A, Meigs JB, O’Donnell CJ, Jacques PF, McKeown NM. Higher magnesium intake reduces risk of impaired glucose and insulin metabolism and progression from prediabetes to diabetes in middle-aged americans. Diabetes Care 2014; 37(2): 419-27.
[http://dx.doi.org/10.2337/dc13-1397] [PMID: 24089547]
[14]
Bo S, Pisu E. Role of dietary magnesium in cardiovascular disease prevention, insulin sensitivity and diabetes. Curr Opin Lipidol 2008; 19(1): 50-6.
[http://dx.doi.org/10.1097/MOL.0b013e3282f33ccc] [PMID: 18196987]
[15]
Abdulaziz LS. Hypomagnesemia in Iraqi Diabetic Patients and Healthy Controls: An Exploratory study. Al - Kindy College of Medicine Journal 2010; 6(1): 74-80.
[16]
Seyoum B, Siraj ES, Saenz C, Abdulkadir J. Hypomagnesemia in Ethiopians with diabetes mellitus. Ethn Dis 2008; 18(2): 147-51.
[PMID: 18507265]
[17]
Syedmoradi L, Ghasemi A, Zahediasl S, Azizi F. Prevalence of hypo- and hypermagnesemia in an Iranian urban population. Ann Hum Biol 2011; 38(2): 150-5.
[http://dx.doi.org/10.3109/03014460.2010.500472] [PMID: 20626252]
[18]
Hyassat D, Al Sitri E, Batieha A, El-Khateeb M, Ajlouni K. Prevalence of hypomagnesaemia among obese type 2 diabetic patients attending the National Center for Diabetes, Endocrinology and Genetics (NCDEG). Int J Endocrinol Metab 2014; 12(3)e17796
[http://dx.doi.org/10.5812/ijem.17796] [PMID: 25237327]
[19]
Jamali AA, Jamali GM, Jamali AA, et al. Association of low serum magnesium levels in type 2 diabetes mellitus with &without hypertension. Open J Prev Med 2018; 8(3): 57-69.
[http://dx.doi.org/10.4236/ojpm.2018.83006]

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy