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Review Article

蛇毒解毒剂：他们与整合素相互作用的概述

卷 20, 期 4, 2019

页: [465 - 477] 页: 13

弟呕挨: 10.2174/1389450119666181022154737

价格: $65

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摘要

解联蛋白是非酶蛋白，其干扰细胞 - 细胞相互作用和信号转导，导致蛇毒的毒性并在毒液中起重要作用。它们的大部分药理和毒性作用是这些分子与细胞表面配体相互作用的结果，这已被广泛描述和研究。这些蛋白质可能作用于血小板，导致出血，并且还可能诱导细胞凋亡和细胞毒性，这突出了血栓溶解剂和抗肿瘤剂的高药理学潜力。另外，这些分子通过改变各种细胞过程如迁移，粘附和增殖来干扰整联蛋白的功能。本综述收集了从蛇毒中分离的崩解剂的功能特征的信息，强调了直接使用这些分子在新药开发中的可能性的综合观点，或者甚至间接作为结构模型。

关键词: 解联蛋白，止血，抗肿瘤，细胞特异性，整合素，药理学应用。

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