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Review Article

链球菌胶原蛋白样蛋白1结合伤口纤连蛋白：病原体靶向的意义

卷 26, 期 11, 2019

页: [1933 - 1945] 页: 13

弟呕挨: 10.2174/0929867325666180831165704

价格: $65

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摘要

A组链球菌（GAS）感染是全世界显着的发病率和死亡率的原因。由于全球GAS菌株之间存在显着的抗原变异，因此降低了有效全球疫苗的前景。 GAS治疗中的其他挑战包括发展中国家缺乏常见的抗生素，以及青霉素过敏和治疗失败以及工业化世界中红霉素抗性增加。在进入的入口处，GAS结合新沉积的细胞外基质，其通过表面粘附素，链球菌胶原蛋白样蛋白1（Scl1）富含具有额外结构域A（EDA，也称为EIIIA）的细胞纤连蛋白同种型。衍生自不同GAS菌株的重组Scl1构建体结合位于C和C''β链之间的EDA环区段。尽管Scl1蛋白中的序列多样性，Scl1变体的多序列比对和二级结构预测，以及结晶学和同源性建模研究，指向Scl1-EDA结合的保守机制。我们建议针对这种相互作用可以预防感染的进展。衍生自EDA C-C''环的合成环肽以微摩尔解离常数与重组Scl1结合。该综述强调了目前EDA与Scl1结合的概念，并提供了利用这种结合来治疗GAS感染和伤口定植的激励。

关键词: Scl1，粘附素，A组链球菌定植，EDA纤连蛋白，伤口微环境，病原体。

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