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General Review Article

骨稳态中的细胞通讯和相关的抗骨质疏松药物开发

卷 27, 期 7, 2020

页: [1151 - 1169] 页: 19

弟呕挨: 10.2174/0929867325666180801145614

价格: $65

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摘要

背景：成骨细胞，破骨细胞，骨细胞和软骨细胞之间的细胞间串扰与骨稳态的精确控制有关。这种细胞和分子信号的破坏将导致代谢性骨疾病，例如骨质疏松症。目前，许多抗骨质疏松症干预措施受到副作用，并发症和长期不耐受的限制。这篇综述旨在总结参与骨重建的骨细胞通讯及其在开发用于骨质疏松症的新药物中的用途。 方法：我们检索1980年1月1日至2018年1月1日的PubMed出版物，以鉴定相关和最新文献，总结骨质疏松症药物的评价和前景。详细的搜索词是“骨质疏松症”，“骨细胞”，“成骨细胞”，“破骨细胞”，“骨重塑”，“软骨细胞”，“骨质疏松症治疗”，“骨质疏松症治疗”，“双膦酸盐”，“ denosumab”，“选择性雌激素”受体调节剂（SERM）”，“ PTH”，“ romosozumab”，“ dkk-1拮抗剂”，“雷奈酸锶”。 结果：共纳入170篇论文。大约80篇论文描述了骨骼重建中涉及的骨细胞相互作用。其余的论文集中在骨质疏松症治疗的新领域和新领域。 结论：参与骨重塑的骨细胞间存在复杂的信号网络。细胞间通讯障碍可能是骨质疏松症的潜在机制。当前的抗骨质疏松疗法是有效的，但是同时具有某些缺点。恢复异常信号网络和个性化治疗对于理想的药物开发至关重要。

关键词: 成骨细胞，破骨细胞，骨细胞，骨稳态，骨质疏松症，治疗。

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