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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Review Article

卵巢癌中的粘着斑激酶：铂和紫杉烷抗性肿瘤的潜在治疗靶点

卷 19, 期 3, 2019

页: [179 - 188] 页: 10

弟呕挨: 10.2174/1568009618666180706165222

价格: $65

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摘要

粘着斑激酶（FAK）是一种非受体酪氨酸激酶，是调节细胞迁移，侵袭，粘附，增殖和存活的重要参与者。已经在68％的上皮性卵巢癌患者中鉴定了其过表达和活化，这与这些患者的更高的肿瘤分期，转移和更短的总体存活率显着相关。最近，FAK出现了一个新的角色，即促进对紫杉烷和铂类治疗卵巢癌和其他癌症的抵抗。抗性的发展是一个复杂的分子过程网络，使得在铂和紫杉烷抗性卵巢癌中鉴定可靶向生物标志物成为一项重大挑战。 FAK过表达上调铂抗性中的ALDH和XIAP活性，并增加紫杉烷抗性肿瘤中的CD44，YB1和MDR-1活性。因此，FAK正在成为这方面具有预后意义的候选者，越来越多的证据表明最近在使用小分子FAK抑制剂的临床前和临床试验中取得了成功。本综述将总结FAK在卵巢癌中的意义和功能，以及其在化疗耐药中的新兴作用。我们将讨论FAK抑制剂在卵巢癌中的现状，它们的治疗能力和局限性，并进一步提出FAK抑制剂与铂和基于紫杉烷的疗法的组合可以是化学治疗抗性疾病的有效方法。

关键词: 粘着斑激酶，卵巢癌，抗性，紫杉烷类，铂类化合物，FAK抑制剂。

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