Login Register Cart 0
Generic placeholder image

Current Protein & Peptide Science

Editor-in-Chief

ISSN (Print): 1389-2037
ISSN (Online): 1875-5550

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Review Article

Research Progress of Bioactive Proteins from the Edible and Medicinal Mushrooms

Author(s): Rong Zhou, Zhao Kun Liu*, Ye Ni Zhang, Jack Ho Wong, Tzi Bun Ng* and Fang Liu*

Volume 20, Issue 3, 2019

Page: [196 - 219] Pages: 24

DOI: 10.2174/1389203719666180613090710

Price: $65

conference banner
Abstract

For centuries, mushrooms have been widely used as traditional Chinese medicine in Asia. Apart from polysaccharides and some small-molecule components, such as flavones, polyphenols and terpenes, mushrooms produce a large number of pharmaceutically active proteins, which have become popular sources of natural antitumor, antimicrobial, immunoenhancing agents. These bioactive proteins include lectins, laccases, Ribosome Inactivating Proteins (RIPs), nucleases, and Fungal Immunomodulatory Proteins (FIPs). The review is to summarize the characterstics of structure and bioactivities involved in antitumor, antiviral, antifungal, antibacterial and immunoenhancing activities of proteins from edible mushrooms, to better understand their mechanisms, and to direct research.

Keywords: Antimicrobial, antitumor, immunoenhancement, mushroom, protein, Asia.

« Previous Next »
[1]
Ling, C.Q.; Yue, X.Q.; Ling, C. Three advantages of using traditional Chinese medicine to prevent and treat tumor. J. Integr. Med., 2014, 12, 331-335.
[2]
Inoue, N.; Inafuku, M.; Shirouchi, B.; Nagao, K.; Yanagita, T. Effect of Mukitake mushroom (Panellus serotinus) on the pathogenesis of lipid abnormalities in obese, diabetic ob/ob mice. Lipids Health Dis., 2013, 12, 1-6.
[3]
Yu, J.; Sun, R.; Zhao, Z.; Wang, Y. Auricularia polytricha polysaccharides induce cell cycle arrest and apoptosis in human lung cancer A549 cells. Int. J. Biol. Macromol., 2014, 68, 67-71.
[4]
Mahendra, R.; Girish, T.; Soloman, P.W. Therapeutic potential of mushroom. Nat. Prod. Rad., 2005, 4, 246-257.
[5]
Valverde, M.; Hernández-Pérez, T.; Paredes-López, O. Edible mushrooms: Improving human health and promoting quality life. Int. J. Microbiol., 2015, 2015, 1-14.
[6]
Patel, S.; Goyal, A. Recent developments in mushrooms as anticancer therapeutics: A review. 3 Biotech, 2012, 2 1-15
[7]
Elsayed, E.A.; El Enshasy, H.; Wadaan, M.A.M.; Aziz, R. Mushrooms: A potential natural source of anti-inflammatory compounds for medical applications. Mediators Inflamm., 2014, 2014, 805841.
[8]
Stajić, M.; Vukojević, J.; Knežević, A.; Laušević, S.D.; Milovanović, I. Antioxidant protective effects of mushroom metabolites. Curr. Top. Med. Chem., 2013, 13, 2660-2676.
[9]
Wasser, S.P. Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides. Appl. Microbiol. Biotechnol., 2002, 60, 258-274.
[10]
Wasser, S.P. Current findings, future trends, and unsolved problems in studies of medicinal mushrooms. Appl. Microbiol. Biotechnol., 2011, 89, 1323-1332.
[11]
Ren, L.; Perera, C.; Hemar, Y. Antitumor activity of mushroom polysaccharides: A review. Food Funct., 2012, 3, 1118-1130.
[12]
Lin, J.Y.; Chou, T.B. Isolation and characterization of a lectin from edible mushroom, Volvariella volvacea. J. Biochem., 1984, 96(1), 35-40.
[13]
Yu, L.G.; Fernig, D.G.; Smith, J.A.; Milton, J.D.; Rhodes, J.M. Reversible inhibition of proliferation of epithelial cell lines by Agaricus bisporus (edible mushroom) lectin. Cancer Res., 1993, 53, 4627-4632.
[14]
Yu, L.Y.; Fernig, D.G.; White, M.R.H.; Spiller, D.G.; Appleton, P.; Evans, R.C.; Grierson, I.; Smith, J.A.; Davies, H.; Gerasimenko, O.V.; Petersen, O.H.; Milton, J.D.; Rhodes, J.M. Edible mushroom (Agaricus bisporus) lectin, which reversibly inhibits epithelial cell proliferation, blocks nuclear localization sequence-dependent nuclear protein import. J. Biol. Chem., 1999, 274, 4890-4899.
[15]
Ditamo, Y.; Rupil, L.L.; Sendra, V.G.; Nores, G.A.; Roth, G.A.; Irazoqui, F.J. In vivo immunomodulatory effect of the lectin from edible mushroom Agaricus bisporus. Food Funct., 2016, 7(1), 262-269.
[16]
Wang, H.X.; Ng, T.B.; Liu, W.K.; Ooi, V.E.; Chang, S.T. Isolation and characterization of two distinct lectins with anti-proliferative activity from the cultured mycelium of the edible mushroom Tricholoma mongolicum. Int. J. Pept. Protein Res., 1995, 46, 508-513.
[17]
Wang, H.X.; Liu, W.K.; Ng, T.B.; Ooi, V.E.C.; Chang, S.T. The immunomodulatory and antitumor activities of lectins from the mushroom Tricholoma mongolicum. Immunopharmacology, 1996, 31, 205-211.
[18]
Wang, H.X.; Ng, T.B.; Ooi, V.E.; Liu, W.K.; Chang, S.T. Actions of lectins from the mushroom Tricholoma mongolicum on macrophages, splenocytes and life-span in sarcoma-bearing mice. Anticancer Res., 1997, 17, 419-424.
[19]
Liu, F.; Ng, T.B.; Wang, H.X.; Fung, M.C.; Ooi, V.E.C. Lectin from Tricholoma mongolicum S. Imai (Agaricomycetideae) mycelia stimulates gene expression of immunomodulating cytokines in mouse peritoneal macrophages and splenocytes. Int. J. Med. Mushrooms, 2005, 7, 243-248.
[20]
She, Q.B.; Ng, T.B.; Liu, W.K. A novel lectin with potent immunomodulatory activity isolated from both fruiting bodies and cultured mycelia of the edible mushroom Volvariella volvacea. Biochem. Biophys. Res. Commun., 1998, 247, 106-111.
[21]
Liu, W.K.; Ho, J.C.K.; Ng, T.B. Suppression of cell cycle progression by a fungal lectin: Activation of cyclin-dependent kinase inhibitors. Biochem. Pharmacol., 2001, 61, 33-37.
[22]
Ho, J.C.K.; Sze, S.C.W.; Shen, W.Z.; Liu, W.K. Mitogenic activity of edible mushroom lectins. Biochim. Biophys. Acta, 2004, 1671, 9-17.
[23]
Wang, H.X.; Gao, J.Q.; Ng, T.B. A new lectin with highly potent antihepatoma and antisarcoma activities from the oyster mushroom Pleurotus ostreatus. Biochem. Biophys. Res. Commun., 2000, 275, 810-816.
[24]
Gao, W.J.; Sun, Y.H.; Chen, S.W.; Zhang, J.Y.; Kang, J.J.; Wang, Y.Q.; Wang, H.X.; Xia, G.L.; Liu, Q.H.; Kang, Y.M. Mushroom lectin enhanced immunogenicity of HBV DNA vaccine in C57BL/6 and HBsAg-transgenic mice. Vaccine, 2013, 31, 2273-2280.
[25]
Koyama, Y.; Katsuno, Y.; Miyoshi, N.; Hayakawa, S.; Mita, T.; Muto, H.; Isemura, S.; Aoyagi, Y.; Isemura, M. Apoptosis induction by lectin isolated from the mushroom Boletopsis leucomelas in U937 cells. Biosci. Biotechnol. Biochem., 2002, 66, 784-789.
[26]
Mahajan, R.G.; Patil, S.I.; Mohan, D.R.; Shastry, P. Pleurotus eous mushroom Lectin (PEL) with mixed carbohydrate inhibition and anti-proliferative activity on tumor cell lines. J. Biochem. Mol. Biol. Biophys., 2002, 6, 341-345.
[27]
Wang, H.X.; Ng, T.B.; Liu, Q.H. A novel lectin from the wild mushroom Polyporus adusta. Biochem. Biophys. Res. Commun., 2003, 307, 535-539.
[28]
Zhao, C.G.; Sun, H.; Tong, X.; Qi, Y.P. An antitumour lectin from the edible mushroom Agrocybe aegerita. Biochem. J., 2003, 374, 321-327.
[29]
Liang, Y.; Feng, L.; Tong, X.; Wang, K.; Li, D.F.; Lin, J.C.; Tang, Z.J.; Liu, H.H.; Jiang, S.; Guo, L.; Wang, D.C.; Sun, H. Importance of nuclear localization for the apoptosis-induced activity of a fungal galectin AAL (Agrocybe aegerita lectin). Biochem. Biophys. Res. Commun., 2009, 386, 437-442.
[30]
Liang, Y.; Lin, J.C.; Wang, K.; Chen, Y.J.; Liu, H.H.; Luan, R.; Jiang, S.; Che, T.; Zhao, Y.; Li, D.F.; Wang, D.C.; Guo, L.; Sun, H. A nuclear ligand MRG15 involved in the proapoptotic activity of medicinal fungal galectin AAL (Agrocybe aegerita lectin). Biochim. Biophys. Acta, 2010, 1800, 474-480.
[31]
Sun, H.; Zhao, C.G.; Tong, X.; Qi, Y.P. A lectin with mycelia differentiation and antiphytovirus activities from the edible mushroom Agrocybe aegerita. J. Biochem. Mol. Biol., 2003, 36, 214-222.
[32]
Trigueros, V.; Lougarre, A.; Ali-Ahmed, D.; Rahbé, Y.; Guillot, J.; Chavant, L.; Fournier, D.; Paquereau, L. Xerocomus chrysenteron lectin: Identification of a new pesticidal protein. Biochim. Biophys. Acta, 2003, 1621, 292-298.
[33]
Marty-Detraves, C.; Francis, F.; Baricault, L.; Fournier, D.; Paquereau, L. Inhibitory action of a new lectin from Xerocomus chrysenteron on cell-substrate adhesion. Mol. Cell. Biochem., 2004, 258, 49-55.
[34]
Ngai, P.H.K.; Ng, T.B. A mushroom (Ganoderma capense) lectin with spectacular thermostability, potent mitogenic activity on splenocytes, and anti-proliferative activity towards tumor cells. Biochem. Biophys. Res. Commun., 2004, 314, 988-993.
[35]
Park, J.H.; Ryu, C.S.; Kim, H.N.; Na, Y.J.; Park, H.J.; Kim, H. A sialic acid-specific lectin from the mushroom Paecilomyces Japonica that exhibits hemagglutination activity and cytotoxicity. Protein Pept. Lett., 2004, 11, 563-569.
[36]
Han, C.H.; Liu, Q.H.; Ng, T.B.; Wang, H.X. A novel homodimeric lactose-binding lectin from the edible split gill medicinal mushroom Schizophyllum commune. Biochem. Biophys. Res. Commun., 2005, 336, 252-257.
[37]
Ng, T.B.; Ngai, P.H.K.; Xia, L.X. An agglutinin with mitogenic and anti-proliferative activities from the mushroom Flammulina velutipes. Mycologia, 2006, 98, 167-171.
[38]
Feng, K.; Liu, Q.H.; Ng, T.B.; Liu, H.Z.; Li, J.Q.; Chen, G.; Sheng, H.Y.; Xie, Z.L.; Wang, H.X. Isolation and characterization of a novel lectin from the mushroom Armillaria luteo-virens. Biochem. Biophys. Res. Commun., 2006, 345, 1573-1578.
[39]
Liu, Q.H.; Wang, H.X.; Ng, T.B. First report of a xylose-specific lectin with potent hemagglutinating, anti-proliferative and anti-mitogenic activities from a wild ascomycete mushroom. Biochim. Biophys. Acta, 2006, 1760, 1914-1919.
[40]
Li, Y.R.; Liu, Q.H.; Wang, H.X.; Ng, T.B. A novel lectin with potent antitumor, mitogenic and HIV-1 reverse transcriptase inhibitory activities from the edible mushroom Pleurotus citrinopileatus. Biochim. Biophys. Acta, 2008, 1780, 51-57.
[41]
Wong, J.H.; Wang, H.X.; Ng, T.B. A haemagglutinin from the medicinal fungus Cordyceps militaris. Biosci. Rep., 2009, 29, 321-327.
[42]
Zhang, G.Q.; Sun, J.; Wang, H.X.; Ng, T.B. A novel lectin with anti-proliferative activity from the medicinal mushroom Pholiota adipose. Acta Biochim. Pol., 2009, 56, 415-421.
[43]
Pohleven, J.; Obermajer, N.; Sabotič, J.; Anžlovar, S.; Sepčić, K.; Kos, J.; Kralj, B.; Štrukelj, B.; Brzin, J. Purification, characterization and cloning of a ricin B-like lectin from mushroom Clitocybe nebularis with anti-proliferative activity against human leukemic T cells. Biochim. Biophys. Acta, 2009, 1790, 173-181.
[44]
Svajger, U.; Pohleven, J.; Kos, J.; Strukelj, B.; Jeras, M. CNL, a ricin B-like lectin from mushroom Clitocybe nebularis, induces maturation and activation of dendritic cells via the toll-like receptor 4 pathway. Immunology, 2011, 134, 409-418.
[45]
Li, Y.R.; Zhang, G.Q.; Ng, T.B.; Wang, H.X. A novel lectin with anti-proliferative and HIV-1 reverse transcriptase inhibitory activities from dried fruiting bodies of the monkey head mushroom Hericium erinaceum. J. Biomed. Biotechnol., 2010, 2010, 716515.
[46]
Zhao, S.; Zhao, Y.C.; Li, S.H.; Zhao, J.K.; Zhang, G.Q.; Wang, H.X.; Ng, T.B. A novel lectin with highly potent anti-proliferative and HIV-1 reverse transcriptase inhibitory activities from the edible wild mushroom Russula delica. Glycoconj. J., 2010, 27, 259-265.
[47]
Zhang, G.Q.; Sun, J.; Wang, H.X.; Ng, T.B. First isolation and characterization of a novel lectin with potent antitumor activity from a Russula mushroom. Phytomedicine, 2010, 17, 775-781.
[48]
Zhao, J.K.; Zhao, Y.C.; Li, S.H.; Wang, H.X.; Ng, T.B. Isolation and characterization of a novel thermostable lectin from the wild edible mushroom Agaricus arvensis. J. Basic Microbiol., 2011, 51, 304-311.
[49]
Wu, Y.Y.; Wang, H.X.; Ng, T.B. Purification and characterization of a lectin with anti-proliferative activity towards cancer cells from the dried fruit bodies of Lactarius flavidulus. Carbohydr. Res., 2011, 346, 2576-2581.
[50]
Jiang, S.; Chen, Y.J.; Wang, M.; Yin, Y.L.; Pan, Y.F.; Gu, B.L.; Yu, G.J.; Li, Y.M.; Wong, B.H.C.; Liang, Y.; Sun, H. A novel lectin from Agrocybe aegerita shows high binding selectivity for terminal N-acetylglucosamine. Biochem. J., 2012, 443, 369-378.
[51]
Rouf, R.; Stephens, A.S.; Spaan, L.; Arndt, N.X.; Day, C.J.; May, T.W.; Tiralongo, E.; Tiralongo, J. G2/M cell cycle arrest by an N-acetyl-D-glucosamine specific lectin from Psathyrella asperospora. Glycoconj. J., 2014, 31, 61-70.
[52]
Wang, S.X.; Zhang, G.Q.; Zhao, S.; Xu, F.; Zhou, Y.; Geng, X.L.; Liu, Y.; Wang, H.X. Purification and characterization of a novel lectin with antiphytovirus activities from the wild mushroom Paxillus involutus. Protein Pept. Lett., 2013, 20, 767-774.
[53]
Zheng, S.Y.; Li, C.S.; Ng, T.B.; Wang, H.X. A lectin with mitogenic activity from the edible wild mushroom Boletus edulis. Process Biochem., 2007, 42, 1620-1624.
[54]
Suzuki, T.; Sugiyama, K.; Hirai, H.; Ito, H.; Morita, T.; Dohra, H.; Murata, T.; Usui, T.; Tateno, H.; Hirabayashi, J.; Kobayashi, Y.; Kawagishi, H. Mannose-specific lectin from the mushroom Hygrophorus russula. Glycobiology, 2012, 22, 616-629.
[55]
Girjal, V.U.; Neelagund, S.; Krishnappa, M. Ganoderma lucidum: A source for novel bioactive lectin. Protein Pept. Lett., 2011, 18, 1150-1157.
[56]
Alborés, S.; Mora, P.; Bustamante, M.J.; Cerdeiras, M.P.; Fraguas, L.F. Purification and applications of a lectin from the mushroom Gymnopilus spectabilis. Appl. Biochem. Biotechnol., 2014, 172, 2081-2090.
[57]
Chandrasekaran, G.; Lee, Y.C.; Park, H.; Wu, Y.; Shin, H.J. Antibacterial and antifungal activities of lectin extracted from fruiting bodies of the Korean cauliflower medicinal mushroom, Sparassis latifolia (Agaricomycetes). Int. J. Med. Mushrooms, 2016, 18(4), 291-299.
[58]
Licastro, F.; Morini, M.C.; Kretz, O.; Dirheimer, G.; Creppy, E.E.; Stirpe, F. Mitogenic activity and immunological properties of bolesatine, a lectin isolated from the mushroom Boletus satanas Lenz. Int. J. Biochem., 1993, 25, 789-792.
[59]
Liu, Q.H.; Wang, H.X.; Ng, T.B. Isolation and characterization of a novel lectin from the wild mushroom Xerocomus spadiceus. Peptides, 2004, 25, 7-10.
[60]
Wang, H.X.; Ng, T.B. First report of an arabinose-specific fungal lectin. Biochem. Biophys. Res. Commun., 2005, 337, 621-625.
[61]
Jung, E.C.; Kim, K.D.; Bae, C.H.; Kim, J.C.; Kim, D.K.; Kim, H.H. A mushroom lectin from ascomycete Cordyceps militaris. Biochim. Biophys. Acta, 2007, 1770, 833-838.
[62]
Coelho, L.C.; Silva, P.M.; Lima, V.L.; Pontual, E.V.; Paiva, P.M.; Napoleão, T.H.; Correia, M.T. Lectins, interconnecting proteins with biotechnological/pharmacological and therapeutic applications. Evid. Based Complement. Alternat. Med., 2017, 2017, 1594074.
[63]
Singh, R.S.; Kaur, H.P.; Kanwar, J.R. Mushroom lectins as promising anticancer substances. Curr. Protein Pept. Sci., 2016, 17(8), 797-807.
[64]
Erjavec, J.; Kos, J.; Ravnikar, M.; Dreo, T.; Sabotič, J. Proteins of higher fungi--from forest to application. Trends Biotechnol., 2012, 30, 259-273.
[65]
Unyayar, A.; Demirbilek, M.; Turkoglu, M.; Celik, A.; Mazmanci, M.A.; Erkurt, E.A.; Unyayar, S.; Cekic, O.; Atacag, H. Evaluation of cytotoxic and mutagenic effects of Coriolus versicolor and Funalia trogii extracts on mammalian cells. Drug Chem. Toxicol., 2006, 29, 69-83.
[66]
Ng, T.B.; Wong, J.H. Fungal proteins with anti-proliferative and anticancer activities. Protein Pept. Lett., 2013, 20, 433-438.
[67]
Zhang, G.Q.; Wang, Y.F.; Zhang, X.Q.; Ng, T.B.; Wang, H.X. Purification and characterization of a novel laccase from the edible mushroom Clitocybe maxima. Process Biochem., 2010, 45, 627-633.
[68]
Wong, J.H.; Ng, T.B.; Jiang, Y.; Liu, F.; Sze, S.C.W.; Zhang, K.Y. Purification and characterization of a laccase with inhibitory activity towards HIV-1 reverse transcriptase and tumor cells from an edible mushroom (Pleurotus cornucopiae). Protein Pept. Lett., 2010, 17, 1040-1047.
[69]
Li, M.; Zhang, G.Q.; Wang, H.X.; Ng, T.B. Purification and characterization of a laccase from the edible wild mushroom Tricholoma mongolicum. J. Microbiol. Biotechnol., 2010, 20, 1069-1076.
[70]
Zhang, G.Q.; Tian, T.; Liu, Y.P.; Wang, H.X.; Chen, Q.J. A laccase with anti-proliferative activity against tumor cells from a white root fungus Abortiporus biennis. Process Biochem., 2011, 46, 2336-2340.
[71]
Hu, D.D.; Zhang, R.Y.; Zhang, G.Q.; Wang, H.X.; Ng, T.B. A laccase with anti-proliferative activity against tumor cells from an edible mushroom, white common Agrocybe cylindracea. Phytomedicine, 2011, 18, 374-379.
[72]
Sun, J.; Chen, Q.J.; Cao, Q.Q.; Wu, Y.Y.; Xu, L.J.; Zhu, M.J.; Ng, T.B.; Wang, H.X.; Zhang, G.Q. A laccase with anti-proliferative and HIV-1 reverse transcriptase inhibitory activities from the mycorrhizal fungus Agaricus placomyces. J. Biomed. Biotechnol., 2012, 2012, 736472.
[73]
Wu, X.L.; Huang, C.Y.; Chen, Q.; Wang, H.X.; Zhang, J.X. A novel laccase with inhibitory activity towards HIV-1 reverse transcriptase and anti-proliferative effects on tumor cells from the fermentation broth of mushroom Pleurotus cornucopiae. Biomed. Chromatogr., 2014, 28, 548-553.
[74]
Zhao, S.; Rong, C.B.; Kong, C.; Liu, Y.; Xu, F.; Miao, Q.J.; Wang, S.X.; Wang, H.X.; Zhang, G.Q. A novel laccase with potent antiproliferative and HIV-1 reverse transcriptase inhibitory activities from mycelia of mushroom Coprinus comatus. BioMed Res. Int., 2014, 2014, 417461.
[75]
Sun, J.; Chen, Q.J.; Zhu, M.J.; Wang, H.X.; Zhang, G.Q. An extracellular laccase with anti-proliferative activity from the sanghuang mushroom Inonotus baumii. J. Mol. Catal., B Enzym., 2014, 99, 20-25.
[76]
Garzillo, A.M.; Colao, M.C.; Buonocore, V.; Oliva, R.; Falcigno, L.; Saviano, M.; Santoro, A.M.; Zappala, R.; Bonomo, R.P.; Bianco, C.; Giardina, P.; Palmieri, G.; Sannia, G. Structural and kinetic characterization of native laccases from Pleurotus ostreatus, Rigidoporus lignosus, and Trametes trogii. J. Protein Chem., 2001, 20, 191-201.
[77]
El-Fakharany, E.M.; Haroun, B.M.; Ng, T.B.; Redwan, E.R.M. Oyster mushroom laccase inhibits Hepatitis C virus entry into peripheral blood cells and hepatoma cells. Protein Pept. Lett., 2010, 17, 1031-1039.
[78]
Wang, H.X.; Ng, T.B. Purification of a novel low-molecular-mass laccase with HIV-1 reverse transcriptase inhibitory activity from the mushroom Tricholoma giganteum. Biochem. Biophys. Res. Commun., 2004, 315, 450-454.
[79]
Wang, H.X.; Ng, T.B. A new laccase from dried fruiting bodies of the monkey head mushroom Hericium erinaceum. Biochem. Biophys. Res. Commun., 2004, 322, 17-21.
[80]
Wang, H.X.; Ng, T.B. A laccase from the medicinal mushroom Ganoderma lucidum. Appl. Microbiol. Biotechnol., 2006, 72, 508-513.
[81]
Wang, H.X.; Ng, T.B. Purification of a laccase from fruiting bodies of the mushroom Pleurotus eryngii. Appl. Microbiol. Biotechnol., 2006, 69, 521-525.
[82]
Sun, J.; Wang, H.X.; Ng, T.B. Isolation of a laccase with HIV-1 reverse transcriptase inhibitory activity from fresh fruiting bodies of the Lentinus edodes (Shiitake mushroom). Indian J. Biochem. Biophys., 2011, 48, 88-94.
[83]
Zou, Y.J.; Wang, H.X.; Ng, T.B.; Huang, C.Y.; Zhang, J.X. Purification and characterization of a novel laccase from the edible mushroom Hericium coralloides. J. Microbiol., 2012, 50, 72-78.
[84]
Xu, L.J.; Wang, H.X.; Ng, T.B. A laccase with HIV-1 reverse transcriptase inhibitory activity from the broth of mycelial culture of the mushroom Lentinus tigrinus. J. Biomed. Biotechnol., 2012, 2012, 536725.
[85]
Zhang, G.Q.; Chen, Q.J.; Wang, H.X.; Ng, T.B. A laccase with inhibitory activity against HIV-1 reverse transcriptase from the mycorrhizal fungus Lepiota ventriosospora. J. Mol. Catal., B Enzym., 2013, 85-86, 31-36.
[86]
Zhu, M.J.; Zhang, G.Q.; Meng, L.; Wang, H.X.; Gao, K.X.; Ng, T.B. Purification and characterization of a white laccase with pronounced dye decolorizing ability and HIV-1 reverse transcriptase inhibitory activity from Lepista nuda. Molecules, 2016, 21, 415.
[87]
Zhang, Y.H.; Wang, Y.; Yusufali, A.H.; Ashby, F.; Zhang, D.; Yin, Z.F.; Aslanidi, G.V.; Srivastava, A.; Ling, C.Q.; Ling, C. Cytotoxic genes from traditional Chinese medicine inhibit tumor growth both in vitro and in vivo. J. Integr. Med., 2014, 12, 483-494.
[88]
Nielsen, K.; Boston, R.S. Ribosome-inactivating proteins: A plant perspective. Annu. Rev. Plant Physiol. Plant Mol. Biol., 2001, 52, 785-816.
[89]
Lam, S.K.; Ng, T.B. Hypsin, a novel thermostable ribosome-inactivating protein with antifungal and anti-proliferative activities from fruiting bodies of the edible mushroom Hypsizigus marmoreus. Biochem. Biophys. Res. Commun., 2001, 285, 1071-1075.
[90]
Ng, T.B.; Lam, Y.W.; Wang, H.X. Calcaelin, a new protein with translation-inhibiting, anti-proliferative and antimitogenic activities from the mosaic puffball mushroom. Planta Med., 2003, 69, 212-217.
[91]
Wong, J.H.; Wang, H.X.; Ng, T.B. Marmorin, a new ribosome inactivating protein with anti-proliferative and HIV-1 reverse transcriptase inhibitory activities from the mushroom Hypsizigus marmoreus. Appl. Microbiol. Biotechnol., 2008, 81, 669-674.
[92]
Pan, W.L.; Wong, J.H.; Fang, E.F.; Chan, Y.S.; Ye, X.J.; Ng, T.B. Differential inhibitory potencies and mechanisms of the type I ribosome inactivating protein marmorin on Estrogen Receptor (ER)-positive and ER-negative breast cancer cells. Biochim. Biophys. Acta, 2013, 1833, 987-996.
[93]
Lam, S.K.; Ng, T.B. First simultaneous isolation of a ribosome inactivating protein and an antifungal protein from a mushroom (Lyophyllum shimeiji) together with evidence for synergism of their antifungal effects. Arch. Biochem. Biophys., 2001, 393, 271-280.
[94]
Wang, H.X.; Ng, T.B. Isolation and characterization of velutin, a novel low-molecular-weight ribosome-inactivating protein from winter mushroom (Flammulina velutipes) fruiting bodies. Life Sci., 2001, 68, 2151-2158.
[95]
Wang, H.X.; Ng, T.B. Flammulin: A novel ribosome-inactivating protein from fruiting bodies of the winter mushroom Flammulina velutipes. Biochem. Cell Biol., 2000, 78, 699-702.
[96]
Ng, T.B.; Wang, H.X. Flammin and velin: New ribosome inactivating polypeptides from the mushroom Flammulina velutipes. Peptides, 2004, 25, 929-933.
[97]
Yao, Q.Z.; Yu, M.M.; Ooi, L.S.M.; Ng, T.B.; Chang, S.T.; Sun, S.S.M.; Ooi, V.E.C. Isolation and characterization of a type 1 ribosome-inactivating protein from fruiting bodies of the edible mushroom (Volvariella volvacea). J. Agric. Food Chem., 1998, 46, 788-792.
[98]
Wang, H.X.; Ng, T.B. Isolation of pleuturegin, a novel ribosome-inactivating protein from fresh sclerotia of the edible mushroom Pleurotus tuber-regium. Biochem. Biophys. Res. Commun., 2001, 288, 718-721.
[99]
Kong, X.H.; Zhang, J.C.; Ma, Q.F.; Han, Z.H.; Zang, P.Q.; Yang, Z.X. Advances in the study of ribonucleases proteins and peptides of mushrooms. J. Fungal Reas, 2008, 6, 119-124.
[100]
Ngai, P.H.K.; Ng, T.B. A ribonuclease with antimicrobial, antimitogenic and anti-proliferative activities from the edible mushroom Pleurotus sajor-caju. Peptides, 2004, 25, 11-17.
[101]
Xia, L.; Chu, K.T.; Ng, T.B. A low-molecular mass ribonuclease from the brown oyster mushroom. J. Pept. Res., 2005, 66, 1-8.
[102]
Guan, G.P.; Wang, H.X.; Ng, T.B. A novel ribonuclease with anti-proliferative activity from fresh fruiting bodies of the edible mushroom Hypsizigus marmoreus. Biochim. Biophys. Acta, 2007, 1770, 1593-1597.
[103]
Zhang, R.Y.; Zhang, G.Q.; Hu, D.D.; Wang, H.X.; Ng, T.B. A novel ribonuclease with anti-proliferative activity from fresh fruiting bodies of the edible mushroom Lyophyllum shimeiji. Biochem. Genet., 2010, 48, 658-668.
[104]
Wu, X.L.; Zheng, S.Y.; Cui, L.; Wang, H.X.; Ng, T.B. Isolation and characterization of a novel ribonuclease from the pink oyster mushroom Pleurotus djamor. J. Gen. Appl. Microbiol., 2010, 6, 231-239.
[105]
Zhao, S.; Zhao, Y.C.; Li, S.H.; Zhang, G.Q.; Wang, H.X.; Ng, T.B. An anti-proliferative ribonuclease from fruiting bodies of the wild mushroom Russula delica. J. Microbiol. Biotechnol., 2010, 20, 693-699.
[106]
Wu, Y.Y.; Wang, H.X.; Ng, T.B. Purification and characterization of a novel RNase with anti-proliferative activity from the mushroom Lactarius flavidulus. J. Antibiot., 2012, 65, 67-72.
[107]
Zhang, R.; Zhao, L.Y.; Wang, H.X.; Ng, T.B. A novel ribonuclease with anti-proliferative activity towards leukemia and lymphoma cells and HIV-1 reverse transcriptase inhibitory activity from the mushroom, Hohenbuehelia serotina. Int. J. Mol. Med., 2014, 33, 209-214.
[108]
Fang, E.F.; Ng, T.B. Ribonucleases of different origins with a wide spectrum of medicinal applications. Biochim. Biophys. Acta, 2011, 1815, 65-74.
[109]
Dan, X.L.; Liu, W.L.; Wong, J.H.; Ng, T.B. A ribonuclease isolated from wild Ganoderma Lucidum suppressed autophagy and triggered apoptosis in colorectal cancer cells. Front. Pharmacol., 2016, 7, 217.
[110]
Chen, Y.J.; Jiang, S.; Jin, Y.X.; Yin, Y.L.; Yu, G.J.; Lan, X.Q.; Cui, M.Y.; Liang, Y.; Wong, B.H.C.; Guo, L.; Sun, H. Purification and characterization of an antitumor protein with deoxyribonuclease activity from edible mushroom Agrocybe aegerita. Mol. Nutr. Food Res., 2012, 56, 1729-1738.
[111]
Zhang, Y.N.; Liu, Z.K.; Ng, T.B.; Chen, Z.H.; Qiao, W.T.; Liu, F. Purification and characterization of a novel antitumor protein with antioxidant and deoxyribonuclease activity from edible mushroom Pholiota nameko. Biochimie, 2014, 99, 28-37.
[112]
Zhou, R.; Han, Y.J.; Zhang, M.H.; Zhang, K.R.; Ng, T.B.; Liu, F. Purification and characterization of a novel ubiquitin-like antitumour protein with hemagglutinating and deoxyribonuclease activities from the edible mushroom Ramaria botrytis. AMB Express, 2017, 7, 47.
[113]
Wang, H.X.; Ng, T.B. Purification of a novel ribonuclease from dried fruiting bodies of the edible mushroom Thelephora ganbajun. Biochem. Biophys. Res. Commun., 2004, 324, 855-859.
[114]
Zhao, Y.C.; Zhang, G.Q.; Ng, T.B.; Wang, H.X. A novel ribonuclease with potent HIV-1 reverse transcriptase inhibitory activity from cultured mushroom Schizophyllum commune. J. Microbiol., 2011, 49, 803-808.
[115]
Zhu, M.J.; Xu, L.J.; Chen, X.; Ma, Z.Q.; Wang, H.X.; Ng, T.B. A novel ribonuclease with HIV-1 reverse transcriptase inhibitory activity from the edible mushroom Hygrophorus russula. Appl. Biochem. Biotechnol., 2013, 170, 219-230.
[116]
Nasu, M.; Carbone, M.; Gaudino, G.; Ly, B.H.; Bertino, P.; Shimizu, D.; Morris, P.; Pass, H.I.; Yang, H. Ranpirnase interferes with NF-κB pathway and MMP9 activity, inhibiting malignant mesothelioma cell invasiveness and xenograft growth. Genes Cancer, 2011, 2, 576-584.
[117]
Kino, K.; Yamashita, A.; Yamaoka, K.; Watanabe, J.; Tanaka, S.; Ko, K.; Shimizu, K.; Tsunoo, H. Isolation and characterization of a new immunomodulatory protein, Lingzhi-8 (LZ-8), from Ganoderma lucidum. J. Biol. Chem., 1989, 264, 472.
[118]
Hsu, H.Y.; Hua, K.F.; Wu, W.C.; Hsu, J.; Weng, S.T.; Lin, T.L.; Liu, C.Y.; Hseu, R.S.; Huang, C.T. Reishi immuno-modulation protein induces interleukin-2 expression via protein kinase-dependent signaling pathways within human T cells. J. Cell. Physiol., 2008, 215, 15-26.
[119]
Lin, Y.L.; Liang, Y.C.; Tseng, Y.S.; Huang, H.Y.; Chou, S.Y.; Hseu, R.S.; Huang, C.T.; Chiang, B.L. An immunomodulatory protein, Ling Zhi-8, induced activation and maturation of human monocyte-derived dendritic cells by the NF-kappa B and MAPK pathways. J. Leukoc. Biol., 2009, 86(4), 86877-86889.
[120]
Yeh, C.H.; Chen, H.C.; Yang, J.J.; Chuang, W.I.; Sheu, F. Polysaccharides PS-G and protein LZ-8 from Reishi (Ganoderma lucidum) exhibit diverse functions in regulating murine macrophages and T lymphocytes. J. Agric. Food Chem., 2010, 58, 8535-8544.
[121]
Lin, T.Y.; Hsu, H.Y. Ling Zhi-8 reduces lung cancer mobility and metastasis through disruption of focal adhesion and induction of MDM2-mediated Slug degradation. Cancer Lett., 2016, 375, 340-348.
[122]
J.L.; Hsu, C.I.; Lin, R.H.; Kao, C.L.; Lin, J.Y. A new fungal immunomodulatory protein, FIP-fve isolated from the edible mushroom, Flammulina velutipes and its complete amino acid sequence. Eur. J. Biochem., 1995, 228, 244-249.
[123]
Wang, P.H.; Hsu, C.I.; Tang, S.C.; Huang, Y.L.; Lin, J.Y.; Ko, J.L. Fungal immunomodulatory protein from Flammulina velutipes induces interferon-γ production through p38 mitogen-activated protein kinase signaling pathway. J. Agric. Food Chem., 2004, 52, 2721-2725.
[124]
Ou, C.C.; Siao, Y.M.; Wu, W.J.; Tasy, G.J.; Ko, J.L.; Lin, M.Y. FIP- fve stimulates interferon-gamma production via modulation of calcium release and PKC-α activation. J. Agric. Food Chem., 2009, 57, 11008-11013.
[125]
Ding, Y.; Seow, S.V.; Huang, C.H.; Liew, L.M.; Lim, Y.C.; Kuo, I.C.; Chua, K.Y. Coadministration of the fungal immunomodulatory protein FIP-Fve and a tumour-associated antigen enhanced antitumour immunity. Immunology, 2009, 128, 881-894.
[126]
Chang, H.H.; Hsieh, K.Y.; Yeh, C.H.; Tu, Y.P.; Sheu, F. Oral administration of an enoki mushroom protein FVE activates innate and adaptive immunity and induces anti-tumor activity against murine hepatocellular carcinoma. Int. Immunopharmacol., 2010, 10, 239-246.
[127]
Su, C.F.; Kuo, I.C.; Chen, P.W.; Huang, C.H.; Seow, S.V.; Chua, K.Y.; Yu, S.M. Characterization of an immunomodulatory Der p 2-FIP-fve fusion protein produced in transformed rice suspension cell culture. Transgenic Res., 2012, 21, 177-192.
[128]
Lin, J.W.; Guan, S.Y.; Duan, Z.W.; Shen, Y.H.; Fan, W.L.; Chen, L.J.; Zhang, L.; Zhang, L.; Li, T.L. Gene cloning of a novel fungal immunomodulatory protein from Chroogomphis rutilus and its expression in Pichia pastoris. J. Chem. Technol. Biotechnol., 2016, 91(11), 2761-2768.
[129]
Kong, X.H.; Zhang, J.C.; Han, X.; Zhang, P.Q.; Dai, X.D.; Liu, J.N.; Zhang, X.X.; Lee, I.; Liu, S.K. High-yield production in Escherichia coli of fungal immunomodulatory protein isolated from Flammulina velutipes and its bioactivity assay in vivo. Int. J. Mol. Sci., 2013, 14, 2230-2241.
[130]
Hsu, H.C.; Hsu, C.I.; Lin, R.H.; Kao, C.L.; Lin, J.Y. Fip-vvo, a new fungal immunomodulatory protein isolated from Volvariella volvacea. Biochem. J., 1997, 323, 557-565.
[131]
Sun, X.L.; Huang, W.; Xiao, S.J.; Liang, C.Y.; Zhang, S.Q.; Liu, Z.Y.; Sun, F. Extracellular expression and efficient purification of a functional recombinant Volvariella volvacea immunomodulatory protein (FIP-vvo) using Pichia pastoris system. Protein Expr. Purif., 2014, 94, 95-100.
[132]
Chang, H.H.; Sheu, F. A novel fungal immunomodulatory protein (PCP) isolated from Poria cocos activates mouse peritoneal macrophage involved in toll-like receptor 4. FASEB J., 2007, 21, 702-715.
[133]
Hsiao, Y.M.; Huang, Y.L.; Tang, S.C.; Shieh, G.J.; Lai, J.Y.; Wang, P.H.; Ying, T.H.; Ko, J.L. Effect of a fungal immunomodulatory protein from Ganoderma tsugae on cell cycle and interferon-gamma production through phosphatidylinositol 3-kinase signal pathway. Process Biochem., 2008, 43, 423-430.
[134]
Sheu, F.; Chien, P.J.; Hsieh, K.Y.; Chin, K.L.; Huang, W.T.; Tsao, C.Y.; Chen, Y.F.; Cheng, H.C.; Chang, H.H. Purification, cloning, and functional characterization of a novel immunomodulatory protein from Antrodia camphorate (bitter mushroom) that exhibits TLR2-dependent NF-κB activation and M1 polarization within murine macrophages. J. Agric. Food Chem., 2009, 57, 4130-4141.
[135]
Lin, C.H.; Sheu, G.T.; Lin, Y.W.; Yeh, C.S.; Huang, Y.H.; Lai, Y.C.; Chang, J.G.; Ko, J.L. A new immunomodulatory protein from Ganoderma microsporum inhibits epidermal growth factor mediated migration and invasion in A549 lung cancer cells. Process Biochem., 2010, 45, 1537-1542.
[136]
Lin, C.H.; Hsiao, Y.M.; Ou, C.C.; Lin, Y.W.; Chiu, Y.L.; Lue, K.H.; Chang, J.G.; Ko, J.L. GMI, a ganoderma immunomodulatory protein, down-regulates tumor necrosis factor α-induced expression of matrix metalloproteinase 9 via NF-κB pathway in human alveolar epithelial A549 cells. J. Agric. Food Chem., 2010, 58, 12014-12021.
[137]
Li, Q.Z.; Wang, X.F.; Chen, Y.Y.; Lin, J.; Zhou, X.W. Cytokines expression induced by Ganoderma sinensis Fungal Immunomodulatory Proteins (FIP-gsi) in mouse spleen cells. Appl. Biochem. Biotechnol., 2010, 162, 1403-1413.
[138]
Li, F.; Wen, H.; Zhang, Y.J.; An, M.; Liu, X.Z. Purification and characterization of a novel immunomodulatory protein from the medicinal mushroom Trametes versicolor. Sci. China Life Sci., 2011, 54, 379-385.
[139]
Hung, C.L.; Chang, A.J.; Kuo, X.K.; Sheu, F. Molecular cloning and function characterization of a new macrophage-activating protein from Tremella fuciformis. J. Agric. Food Chem., 2014, 62, 1526-1535.
[140]
Lam, Y.W.; Ng, T.B.; Wang, H.X. Anti-proliferative and antimitogenic activities in a peptide from puffball mushroom Calvatia caelata. Biochem. Biophys. Res. Commun., 2001, 289, 744-749.
[141]
Ngai, P.H.K.; Wang, H.X.; Ng, T.B. Purification and characterization of a ubiquitin-like peptide with macrophage stimulating, anti-proliferative and ribonuclease activities from the mushroom Agrocybe cylindracea. Peptides, 2003, 24, 639-645.
[142]
Chu, K.T.; Xia, L.X.; Ng, T.B. Pleurostrin, an antifungal peptide from the oyster mushroom. Peptides, 2005, 26, 2098-2103.
[143]
Sarangi, I.; Ghosh, D.; Bhutia, S.K.; Mallick, S.K.; Maiti, T.K. Anti-tumor and immunomodulating effects of Pleurotus ostreatus mycelia-derived proteoglycans. Int. Immunopharmacol., 2006, 6, 1287-1297.
[144]
Ngai, P.H.K.; Ng, T.B. A hemolysin from the mushroom Pleurotus eryngii. Appl. Microbiol. Biotechnol., 2006, 72, 1185-1191.
[145]
Chen, J.N.; Wang, Y.T.; Wu, J.S.B. A glycoprotein extracted from golden oyster mushroom Pleurotus citrinopileatus exhibiting growth inhibitory effect against U937 leukemia cells. J. Agric. Food Chem., 2009, 57, 6706-6711.
[146]
Chen, J.N.; Ma, C.Y.; Tsai, P.F.; Wang, Y.T.; Wu, J.S.B. In vitro antitumor and immunomodulatory effects of the protein PCP-3A from mushroom Pleurotus citrinopileatus. J. Agric. Food Chem., 2010, 58, 12117-12122.
[147]
Park, B.T.; Na, K.H.; Jung, E.C.; Park, J.W.; Kim, H.H. Antifungal and anticancer activities of a protein from the mushroom Cordyceps militaris. Korean J. Physiol. Pharmacol., 2009, 13, 49-54.
[148]
Wong, J.H.; Ng, T.B.; Wang, H.X.; Sze, S.C.W.; Zhang, K.Y.; Li, Q.; Lu, X.X. Cordymin, an antifungal peptide from the medicinal fungus Cordyceps militaris. Phytomedicine, 2011, 18, 387-392.
[149]
Sun, J.; Zhao, Y.C.; Chai, H.M.; Wang, H.X.; Ng, T.B. A novel alkaline protease with anti-proliferative activity from fresh fruiting bodies of the toxic wild mushroom Amanita farinosa. Acta Biochim. Pol., 2011, 58, 567-572.
[150]
Tsai, P.F.; Ma, C.Y.; Wu, J.S.B. A novel glycoprotein from mushroom Hypsizygus marmoreus (Peck) Bigelow with growth inhibitory effect against human leukaemic U937 cells. Food Chem., 2013, 141, 1252-1258.
[151]
Tsai, P.F.; Ma, C.Y. Effect of a glycoprotein from mushroom Hypsizygus marmoreus (Peck) Bigelow on growth and differentiation of human leukemic U937 cells. Food Chem. Toxicol., 2013, 62, 782-785.
[152]
Wang, H.X.; Ng, T.B. Isolation of a novel ubiquitin-like protein from Pleurotus ostreatus mushroom with anti-human immunodeficiency virus, translation-inhibitory, and ribonuclease activities. Biochem. Biophys. Res. Commun., 2000, 276, 587-593.
[153]
Wang, H.X.; Ng, T.B. Pleureryn, a novel protease from fresh fruiting bodies of the edible mushroom Pleurotus eryngii. Biochem. Biophys. Res. Commun., 2001, 289, 750-755.
[154]
Guo, Y.X.; Wang, H.X.; Ng, T.B. Isolation of trichogin, an antifungal protein from fresh fruiting bodies of the edible mushroom Tricholoma giganteum. Peptides, 2005, 26, 575-580.
[155]
Ngai, P.H.K.; Zhao, Z.; Ng, T.B. Agrocybin, an antifungal peptide from the edible mushroom Agrocybe cylindracea. Peptides, 2005, 26, 191-196.
[156]
Hu, Z.; Ye, M.Q.; Xia, L.Q.; Tu, W.J.; Li, L.; Zou, G.L. Purification and characterization of an antibacterial protein from the cultured mycelia of Cordyceps sinensis. Wuhan Da Xue Xue Bao Zi Ran Ke Xue Ban, 2006, 11, 709-714.
[157]
Wang, J.B.; Wang, H.X.; Ng, T.B. A peptide with HIV-1 reverse transcriptase inhibitory activity from the medicinal mushroom Russula paludosa. Peptides, 2007, 28, 560-565.
[158]
Han, C.H.; Zhang, G.Q.; Wang, H.X.; Ng, T.B. Schizolysin, a hemolysin from the split gill mushroom Schizophyllum commune. FEMS Microbiol. Lett., 2010, 309, 115-121.
[159]
Zheng, S.Y.; Liu, Q.H.; Zhang, G.Q.; Wang, H.X.; Ng, T.B. Purification and characterization of an antibacterial protein from dried fruiting bodies of the wild mushroom Clitocybe sinopica. Acta Biochim. Pol., 2010, 57, 43-48.
[160]
Hu, Q.X.; Zhang, G.Q.; Zhang, R.Y.; Hu, D.D.; Wang, H.X.; Ng, T.B. A novel aspartic protease with HIV-1 reverse transcriptase inhibitory activity from fresh fruiting bodies of the wild mushroom Xylaria hypoxylon. J. Biomed. Biotechnol., 2012, 2012, 728975.
[161]
Sheu, F.; Chien, P.J.; Chien, A.L.; Chen, Y.F.; Chin, K.L. Isolation and characterization of an immunomodulatory protein (APP) from the Jew’s Ear mushroom Auricularia polytricha. Food Chem., 2004, 87, 593-600.
[162]
Yuan, B.; Zhao, L.; Rakariyatham, K.; Han, Y.; Gao, Z.; Muinde Kimatu, B.; Hu, Q.; Xiao, H. Isolation of a novel bioactive protein from an edible mushroom Pleurotus eryngii and its anti-inflammatory potential. Food Funct., 2017, 8, 2175-2183.

Rights & Permissions Print Cite
Article Metrics
99
9
Wayfinder Image
© 2024 Bentham Science Publishers | Privacy Policy