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Current Protein & Peptide Science

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ISSN (Print): 1389-2037
ISSN (Online): 1875-5550

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Review Article

Anti-Tumor Effects of Melittin and Its Potential Applications in Clinic

Author(s): Can Lyu, Fanfu Fang and Bai Li*

Volume 20, Issue 3, 2019

Page: [240 - 250] Pages: 11

DOI: 10.2174/1389203719666180612084615

Price: $65

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Abstract

Melittin, a major component of bee venom, is a water-soluble toxic peptide of which a various biological effects have been identified to be useful in anti-tumor therapy. In addition, Melittin also has anti-parasitic, anti-bacterial, anti-viral, and anti-inflammatory activities. Therefore, it is a very attractive therapeutic candidate for human diseases. However, melittin induces extensive hemolysis, a severe side effect that dampens its future development and clinical application. Thus, studies of melittin derivatives and new drug delivery systems have been conducted to explore approaches for optimizing the efficacy of this compound, while reducing its toxicity. A number of reviews have focused on each side, respectively. In this review, we summarize the research progress on the anti-tumor effects of melittin and its derivatives, and discuss its future potential clinical applications.

Keywords: Melittin, bee venom, melittin derivatives, anti-tumor effect, hemolysis, clinical applications.

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