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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Review Article

用于癌症治疗的细胞衰老诱导小分子

卷 19, 期 2, 2019

页: [109 - 119] 页: 11

弟呕挨: 10.2174/1568009618666180530092825

价格: $65

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摘要

最近，化学治疗药物诱导的细胞衰老被认为是一种很有前景的抗癌方法。 药物诱导的衰老表现出来自复制和癌基因诱导的衰老的相似和不同的标志，被认为是体外和体内肿瘤对化疗反应的关键决定因素。 迄今为止，已经报道了一定量的能够引起癌细胞衰老的有效化学治疗药物。 这些药物的靶标存在显着差异，包括衰老信号传导途径，DNA复制过程，DNA损伤途径，表观遗传修饰，微管聚合，衰老相关分泌表型（SASP）等。 通过总结诱导衰老的小分子药物及其特定的性状和相应的机制，本综述致力于通过诱导衰老开发新的抗癌治疗策略。

关键词: 癌症，衰老，小分子药物，DNA损伤反应，衰老相关的信号通路，SASP

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图形摘要

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