摘要
在过去的二十年里,寻找治疗酒精成瘾的新型药物疗法是一项全球性的努力。这导致了几种药物被批准并成功上市供公众使用,而有些药物还在试验阶段。这些药理学药物虽然对治疗酒精中毒很有效,但也并非没有缺点,例如滥用潜力、严重的身心不良影响、与酒精的相互作用以及代谢和排泄不良。随着人们对酒精成瘾的神经生物学以及这些药物独特的药理作用的进一步了解,新的药物在联合治疗中作为辅助药物被评价为潜在的益处。本文综述了新的药物治疗方法在酒精成瘾治疗中的应用,重点介绍了内拉米克、加巴喷丁、巴氯芬、阿立哌唑、纳马芬和奎硫平等药物。
关键词: 酒精,内拉米克,加巴喷丁,巴氯芬,阿立哌唑,纳马芬,奎硫平。
Current Drug Targets
Title:Novel Pharmacotherapeutic Approaches in Treatment of Alcohol Addiction
Volume: 19 Issue: 12
关键词: 酒精,内拉米克,加巴喷丁,巴氯芬,阿立哌唑,纳马芬,奎硫平。
摘要: In the past two decades, the search for novel pharmacotherapies to treat alcohol addiction has been a global endeavor. This has resulted in several drugs that have been approved and successfully marketed for public use while some are still in the testing phase. These pharmacological agents, though effective for the treatment of alcoholism, are not without shortcomings; such as abuse potential, serious mental and physical adverse effects, interaction with alcohol and also poor metabolism and excretion. As more is being understood about the neurobiology of alcohol addiction as well as the unique pharmacological action of these drugs, new agents are evaluated for potential benefits when used as an adjunct in combination therapy. This review article summarizes the novel pharmacotherapeutic approaches used in the treatment of alcohol addiction by focusing on the drugs, which include neramexane, gabapentin, baclofen, aripiprazole, nalmafene, and quetiapine.
Export Options
About this article
Cite this article as:
Novel Pharmacotherapeutic Approaches in Treatment of Alcohol Addiction, Current Drug Targets 2018; 19 (12) . https://dx.doi.org/10.2174/1389450119666180523092534
DOI https://dx.doi.org/10.2174/1389450119666180523092534 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Call for Papers in Thematic Issues
Drug-Targeted Approach with Polymer Nanocomposites for Improved Therapeutics
Polymer nanocomposites have been recognized as an advanced and cutting-edge technique in drug targeting administration. These materials combine the unique features of nanoparticles with the adaptability of polymers to produce highly personalized drug administration devices. Integrating nanoparticles containing pharmaceuticals into a polymer matrix enables researchers to regulate the rates at ...read more
New drug therapy for eye diseases
Eyesight is one of the most critical senses, accounting for over 80% of our perceptions. Our quality of life might be significantly affected by eye disease, including glaucoma, diabetic retinopathy, dry eye, etc. Although the development of microinvasive ocular surgery reduces surgical complications and improves overall outcomes, medication therapy is ...read more
Therapeutic Chemical and RNA Design with Artificial Intelligence
Computer-Aided Drug Design (CADD) has emerged as a fundamental component of modern drug discovery. Molecular docking facilitates virtual screening on a large scale through structural simulations. However, traditional CADD approaches face significant limitations, as they can only screen known compounds from existing libraries. PubChem, as the most widely used chemical ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Use of Anti-Epileptic Medication in Women with Affective Disorders in Early and Late Pregnancy and During Breastfeeding
Current Women`s Health Reviews Lycopene: A Review of Its Potential as an Anticancer Agent
Current Medicinal Chemistry - Anti-Cancer Agents Endogenous Cardioprotective Agents: Role in Pre and Postconditioning
Current Drug Targets Hybrid High Exploration Particle Swarm Optimization Algorithm Improves the Prediction of the 2-Dimensional Hydrophobic-Polar Model for Protein Folding
Current Bioinformatics A Mini Review on the Chemistry and Neuroprotective Effects of Silymarin
Current Drug Targets Critical Role of Computer Simulations in Drug Discovery and Development
Current Topics in Medicinal Chemistry Neurodegenerative Diseases Associated with Mitochondrial DNA Mutations
Current Pharmaceutical Design Intramolecular Immunological Signal Hypothesis Revived - Structural Background of Signalling Revealed by Using Congo Red as a Specific Tool
Mini-Reviews in Medicinal Chemistry Ischemic Colitis: Current Diagnosis and Treatment
Current Drug Targets Potential Targets for Anti-Inflammatory and Anti-Allergic Activities of Marine Algae: An Overview
Inflammation & Allergy - Drug Targets (Discontinued) Meet Our Editorial Board Member
CNS & Neurological Disorders - Drug Targets Immune Responses to Gene Product of Inducible Promoters
Current Gene Therapy Evidences for the Anti-panic Actions of Cannabidiol
Current Neuropharmacology Astrocytes as a 5-HT2B-Mediated SERT-Independent SSRI Target, Slowly Altering Depression-Associated Genes and Function
Current Signal Transduction Therapy De-Novo Ligand Design against Mutated Huntington Gene by Ligand-based Pharmacophore Modeling Approach
Current Computer-Aided Drug Design Transcriptional Regulation of Cytochrome P450 2B Genes by Nuclear Receptors
Current Drug Metabolism Impact of Ondansetron on Withdrawal Signs, Fentanyl Requirement and Pain Relief in Opioid-addicted Patients under General Anesthesia
Current Clinical Pharmacology Radiosyntheses using Fluorine-18: The Art and Science of Late Stage Fluorination
Current Topics in Medicinal Chemistry Statins and Alkylphospholipids as New Anticancer Agents Targeting Lipid Metabolism
Anti-Cancer Agents in Medicinal Chemistry Synthesis, In Vitro Anticancer, Anti-Inflammatory and DNA Binding Activity of Thiazolidinedione Derivatives
Anti-Cancer Agents in Medicinal Chemistry