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Review Article

钾通道调节剂的药物化学近期进展的最新进展（2011-2017）

卷 26, 期 12, 2019

页: [2062 - 2084] 页: 23

弟呕挨: 10.2174/0929867325666180430152023

价格: $65

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摘要

背景：钾（K +）通道参与许多生理过程，心脏功能，细胞增殖，神经元信号，肌肉收缩性，免疫功能，激素分泌，渗透压，基因表达的变化，并参与关键的生物学功能，并在各种疾病。钾通道代表一大类四聚体膜蛋白。钾通道激活降低了兴奋性，而通道抑制增加了兴奋性。 目的：小分子K +通道激活剂和抑制剂与电压门控，内向整流和双孔串联钾通道相互作用。由于它们参与生物功能和各种疾病，作为钾通道调节剂的小分子受到了极大的科学关注。 方法：在本综述中，我们编制了与不同化学类别的钾通道开放剂和阻断剂相关的文献，专利和专利申请（2011至2017），作为治疗各种疾病的治疗剂。在过去几年中，许多不同化学类别的选择性小分子已经出现作为钾通道调节剂。 结论：本综述讨论了目前对钾通道调节剂领域药物化学研究的理解，以更新该领域的关键进展。

关键词: 钾通道调节剂，钾通道开放剂，钾通道阻滞剂，ATP敏感性钾通道，电压门控钾通道，内向整流钾通道。

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