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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Review Article

糖酵解抑制是肝癌治疗的一种策略？

卷 19, 期 1, 2019

页: [26 - 40] 页: 15

弟呕挨: 10.2174/1568009618666180430144441

价格: $65

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摘要

肝细胞癌(Hepatocellularcarcinoma，HCC)是最常见的原发性肝癌，以其高发病率和高死亡率代表着世界范围内的公共卫生问题。肝癌通常在晚期发现，排除使用治疗的意图。因此，寻找有效的治疗肝癌的方法是至关重要的。癌细胞对g有很高的依赖性。用于产生ATP的溶解，特别是在低氧环境下。这种依赖提供了一个可靠的可能的策略，专门针对癌症细胞的基础上，抑制糖酵解。肝癌，如其他类型的癌症，出现了一个临床知名的上调几个糖酵解关键酶和蛋白质，包括葡萄糖转运蛋白，特别是葡萄糖转运蛋白1(GLUT 1)。斯UCH酶和蛋白质是治疗的潜在靶点。事实上，对于其中的一些目标，已经有一些抑制剂的报道，如2-脱氧葡萄糖，伊马替尼或类黄酮。尽管糖酵解的抑制具有很大的抗癌潜力，糖酵解抑制剂作为一类新的抗癌药物的开发还有待进一步探索。在此，我们综述、讨论和介绍抑制肝癌细胞糖酵解代谢的不同途径，这些方法在肝癌的治疗中可能是非常有效的。

关键词: 糖酵解，肝细胞癌，癌症，GLOBOCAN，EGFR，过剩。

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