摘要
缺血性中风是发达国家死亡率和永久性残疾的主要原因之一。中风诱导大量谷氨酸释放，这反过来导致N-甲基-D-天冬氨酸（NMDA）受体过度激发，因此，神经元中的钙超载通过凋亡级联导致细胞死亡。犬尿氨酸途径是色氨酸分解代谢的复杂酶促级联，产生各种神经活性代谢物。一种代谢产物犬尿喹啉酸（KYNA）是一种有效的内源性NMDA谷氨酸受体拮抗剂，使其成为降低兴奋性毒性和神经炎症的可能治疗工具。最近，临床研究表明，在缺血性中风的急性期，犬尿氨酸途径被激活并且外周水平的代谢物与更差的结果相关。在这篇综述中，我们总结了目前关于犬尿氨酸途径与缺血性卒中关系的文献，并为未来的研究和潜在的药物开发设定了一个方向。
关键词: 犬尿氨酸，中风，缺血，免疫调节，犬尿氨酸类似物，兴奋毒性。
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