摘要
背景：活化小胶质细胞通过产生多种促炎介质，包括对神经元和少突胶质细胞有毒的肿瘤坏死因子-α（TNF-α），白细胞介素-1β（IL-1β）和一氧化氮（NO），在神经退行性疾病中发挥关键作用。 。 方法：鉴于上述情况，抑制小胶质细胞介导的神经炎症被认为是神经退行性疾病的治疗策略。据报道，几种潜在的中草药提取物对特异性靶向活化的小胶质细胞的神经退行性疾病发挥神经保护作用。在这方面，酚类葡萄糖苷天麻素是中草药天麻的主要成分，在当地社区广泛产生，通过抑制神经毒性促炎介质显示出潜在的神经保护作用。 结果：在这里，我们首先回顾激活的小胶质细胞在不同脑疾病中的作用。然后考虑天麻素对活化的小胶质细胞的影响。我们已经将天麻素鉴定为推定的治疗剂，因为已发现其可抑制小胶质细胞活化，从而改善神经炎症。更重要的是，天麻素下调肾素血管紧张素系统（RAS）的表达和促炎介质的产生。值得注意的是，天麻素促进Sirtuin 3（Sirt3）上调和烟酰胺腺嘌呤二核苷酸磷酸氧化酶-2（NOX-2）下调后激活的小胶质细胞中由AT1或AT2受体介导的血管紧张素II受体亚型，表明可能的分子RAS和Sirt3生存基因之间的联系。 结论：本综述总结了天麻素作用于活化小胶质细胞和其他草药化合物的有益作用。它在神经保护方面的功效与中国一些常见的草药产品一致。
关键词: 天麻素，活化小胶质细胞，肾素血管紧张素系统-Sirtuin 3信号，抗炎，神经保护，草药化合物。
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
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Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
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