摘要
背景：。相当多的证据表明二硫代氨基甲酸盐，特别是双硫仑作为抗癌药物的重要性然而，没有系统评价概述了它们的金属结合能力如何与其抗癌活性相关本综述旨在总结双硫仑及其代谢物DEDTC的化学特征和金属结合活性，并讨论双硫仑的不同作用机制及其对该药物抗癌活性的贡献。 方法：我们对同行评议的研究文献的书目数据库进行了双硫仑相关检索，包括许多历史性论文以及体外，体内，临床前和临床研究选定的论文进行了仔细的审查和总结。 结果：在初步搜索中获得了超过五百篇论文，并且纳入了一百八十（118）篇论文，其中大部分论文涉及双硫仑的化学和生物学方面及其化学和生物学性质的关系。81篇论文概述了二硫代氨基甲酸酯的生物学方面，并且五十七（57）论文文报双硫仑作为蛋白酶体或醛脱氢酶抑制剂的抑制剂，与其他抗癌药物的相互作用或与活性氧相关的作用机制种类。所回顾的其他论文集中在二硫代氨基甲酸盐的化学方面。 结论：该综述证实了化合物如双硫仑对其生物活性的重要性，并支持将DSF用作潜在的抗癌剂。
关键词: 双硫仑，金属，二硫代氨基甲酸盐，蛋白酶体抑制剂，抗癌药物，旧药的新用途。
Call for Papers in Thematic Issues
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Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
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