Abstract
Background: Gastric cancer is a malignancy with high mortality rate worldwide. Poor clinical symptoms, unfavorable prognosis and absence of proper diagnostic techniques for early detection cause death in many patients. Presence of new sensitive and specific biomarkers for early detection and progression of GC could lead to reduction in the mortality rate. In addition to intracellular miRNAs, circulating miRNAs reflect the state of cancer progression and might be potential biomarkers for rapid detection and also therapy in GC.
Objective: After giving a brief explanation about circulating miRNAs and their various types, we then reviewed comprehensively the last studies which investigated circulating miRNAs as diagnostic/prognostic biomarkers in GC.
Methods: Research and review articles in PubMed and Scopus databases were summarized. Keywords mainly used were in related to circulating miRNAs and their diagnostic and prognostic value in gastric cancer. Among the numerous circulating miRNAs a comparison was made based on their repeatability, specificity and sensitivity.
Results: Comparisons indicated high diagnostic value of circulating miRNAs in comparison with other detection methods based on their high sensitivity and specificity. There was also a relation between altered expression level of large number of circulating miRNAs and clinicopathological factors and also response to therapy in GC.
Conclusion: Several advantages of circulating miRNAs as detection biomarker have led to extensive studies and significant advances. Altered expression pattern of circulating miRNAs have correlation with pathological status of GC tissues and their exclusive features make them ideal early diagnostic, prognostic and predictive biomarkers for GC.
Keywords: Circulating miRNAs, gastric cancer, biomarker, diagnosis, prognosis, exosomes.
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the Treatment of Chronic Inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
Related Journals
Anti-Cancer Agents in Medicinal Chemistry
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Current Analytical Chemistry
Current Computer-Aided Drug Design
Current Bioactive Compounds
Current Cancer Drug Targets
Combinatorial Chemistry & High Throughput Screening
Current Cancer Therapy Reviews
Current Diabetes Reviews
Current Drug Safety
Related Books
COVID-19: Causes, Transmission, Diagnosis, and Treatment
2-Deoxy-D-Glucose: Chemistry and Biology
Chiral Ionic Liquids: Applications in Chemistry and Technology
Anthocyanins: Pharmacology and Nutraceutical Importance
Herbal Medicine for Autoimmune Diseases
Therapeutic Insights into Herbal Medicine through the Use of Phytomolecules
Computer-Aided Drug Discovery Methods: A Brief Introduction
The Roles and Responsibilities of Clinical Pharmacists in Hospital Settings
Bioactive Compounds from Medicinal Plants for Cancer Therapy and Chemoprevention
Biochar - Solid Carbon for Sustainable Agriculture
74
11