The Transport Mechanism of Extracellular Vesicles at the Blood-Brain Barrier

Title:The Transport Mechanism of Extracellular Vesicles at the Blood-Brain Barrier

Volume: 23 Issue: 40

Author(s): Junichi Matsumoto, Tessandra Stewart, William A. Banks and Jing Zhang*

Affiliation:

• Department of Pathology, University of Washington School of Medicine, Seattle, Washington,United States

Keywords: Adsorptive-mediated transcytosis (AMT), blood-brain barrier (BBB), extracellular vesicles (EVs), endothelial cell, exosome, neurodegenerative disease, Parkinson’s disease (PD), receptor-mediated transcytosis (RMT).

Abstract: Recently, extracellular vesicles (EVs), like exosomes and microvesicles, have attracted attention as potent carriers of intercellular communication throughout the body, including the brain. They transmit biological signals from donor cells to recipient cells, and recent evidence suggests that they may even carry such signals to distant destinations through peripheral circulation. In the central nervous system (CNS), EVs contribute to maintaining normal neuronal function, as well as to the pathological development of neurodegenerative diseases. Although some evidence has suggested that EVs can cross the blood-brain barrier (BBB), moving from the peripheral circulation to the CNS, the mechanisms by which EVs facilitate communication between peripheral tissues and the CNS are not well understood. The BBB is a dynamic interface that regulates molecular trafficking between the peripheral circulation and the CNS. However, there is limited mechanistic understanding of how bloodborne EVs cross the BBB under physiological and pathological conditions. In this review, we focus on current knowledge of trafficking of EVs between the peripheral circulation and the brain. Moreover, we describe hypothetical transport routes by which EVs may cross the BBB based on previous reports. Further investigation is needed to understand the precise mechanisms by which EVs are transported across the BBB.

Cite this article as:

Matsumoto Junichi , Stewart Tessandra, Banks A. William and Zhang Jing *, The Transport Mechanism of Extracellular Vesicles at the Blood-Brain Barrier, Current Pharmaceutical Design 2017; 23 (40) . https://dx.doi.org/10.2174/1381612823666170913164738