摘要
背景:植物医学已被广泛接受的替代补充疗法用于治疗范围广泛的急性和慢性皮肤炎症性疾病,包括慢性疱疹和慢性疱疹。去,银屑病,特应性皮炎(AD)。大量的体外和体内研究证明了植物医学、多药制剂、植物材料和植物材料的治疗可行性。治疗轻、重度AD的红外煎药。 目的:总结和批判性地讨论植物药物治疗AD的临床疗效,并探讨其抗AD作用。accyaccessory 附件 结果:对一种广谱算法的批判性分析表明,其抗AD作用的显著原因在于其具有减轻红斑强度、水肿、炎症的作用。组织胺、免疫球蛋白(Ig)-E、前列腺素、肥大细胞等AD相关炎症生物标志物mRNA的表达受到明显抑制。血清和皮肤活检中细胞因子和趋化因子的过滤和产生。 结论:中草药作为单药治疗轻到中度AD和治疗MOD有很大的应用前景。当与其他药物一起使用时,抗至严重的AD。
关键词: 植物医学,民族药理学,特应性皮炎,机械洞察力,补充和替代疗法。
Current Drug Targets
Title:Phytomedicines are Efficient Complementary Therapies for the Treatment of Atopic Dermatitis: A Review of Mechanistic Insight and Recent Updates
Volume: 19 Issue: 6
关键词: 植物医学,民族药理学,特应性皮炎,机械洞察力,补充和替代疗法。
摘要: Background: Phytomedicines have been well-accepted alternative complementary therapies for the treatment of a wide range of acute and chronic skin inflammatory diseases including chronic herpes, prurigo, psoriasis, and atopic dermatitis (AD). A plethora of in vitro and in vivo studies have evidenced the therapeutic viability of phytomedicines, polyherbal formulations, plant-based materials and their decoctions for the treatment of mild-to-severe AD.
Objective: This review was aimed to summarize and critically discuss the convincing evidence for the therapeutic effectiveness of phytomedicines for the treatment of AD and explore their anti-AD efficacy.
Results: The critical analysis of a wide algorithm of herbal medicines revealed that their remarkable anti-AD efficacy is attributed to their potential of reducing erythema intensity, oedema, inflammation, transepidermal water loss (TEWL) and a remarkable suppression of mRNA expression of ADassociated inflammatory biomarkers including histamine, immunoglobulin (Ig)-E, prostaglandins, mast cells infiltration and production of cytokines and chemokines in the serum and skin biopsies.
Conclusion: In conclusion, herbal medicines hold great promise as complementary and alternative therapies for the treatment of mild-to-moderate AD when used as monotherapy and for the treatment of moderate-to-severe AD when used in conjunction with other pharmacological agents.
Export Options
About this article
Cite this article as:
Phytomedicines are Efficient Complementary Therapies for the Treatment of Atopic Dermatitis: A Review of Mechanistic Insight and Recent Updates, Current Drug Targets 2018; 19 (6) . https://dx.doi.org/10.2174/1389450118666170913162147
DOI https://dx.doi.org/10.2174/1389450118666170913162147 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Call for Papers in Thematic Issues
Drug-Targeted Approach with Polymer Nanocomposites for Improved Therapeutics
Polymer nanocomposites have been recognized as an advanced and cutting-edge technique in drug targeting administration. These materials combine the unique features of nanoparticles with the adaptability of polymers to produce highly personalized drug administration devices. Integrating nanoparticles containing pharmaceuticals into a polymer matrix enables researchers to regulate the rates at ...read more
New drug therapy for eye diseases
Eyesight is one of the most critical senses, accounting for over 80% of our perceptions. Our quality of life might be significantly affected by eye disease, including glaucoma, diabetic retinopathy, dry eye, etc. Although the development of microinvasive ocular surgery reduces surgical complications and improves overall outcomes, medication therapy is ...read more
Therapeutic Chemical and RNA Design with Artificial Intelligence
Computer-Aided Drug Design (CADD) has emerged as a fundamental component of modern drug discovery. Molecular docking facilitates virtual screening on a large scale through structural simulations. However, traditional CADD approaches face significant limitations, as they can only screen known compounds from existing libraries. PubChem, as the most widely used chemical ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Cancer Stem Cells and Chemoresistance in Ewing Sarcoma
Current Stem Cell Research & Therapy Promising Pharmacological, Molecular and Cellular Treatments of Autoimmune Hepatitis
Current Pharmaceutical Design PDE5 Inhibitors in Non-Urological Conditions
Current Pharmaceutical Design Age-related Changes in Respiratory Function and Daily Living. A Tentative Model Including Psychosocial Variables, Respiratory Diseases and Cognition
Current Aging Science Review of Pediatric Osteoarticular Infections
Reviews on Recent Clinical Trials Interpersonal-Psychological Precursors to Suicidal Behavior: A Theory of Attempted and Completed Suicide
Current Psychiatry Reviews Secondary Radiation-Induced Bone Tumours Demonstrate a High Degree of Genomic Instability Predictive of a Poor Prognosis
Current Genomics Genetic Predisposition to Neonatal Tumors
Current Pediatric Reviews Cryptosporidiosis in Yellow Nail Syndrome – A Rare Case Report
Infectious Disorders - Drug Targets FK506 Binding Proteins as Targets in Anticancer Therapy
Anti-Cancer Agents in Medicinal Chemistry Structural Magnetic Resonance Imaging Findings in Posttraumatic Stress Disorder and Their Response to Treatment: A Systematic Review
Current Psychiatry Reviews Gene Therapy for Chronic Granulomatous Disease: Current Status and Future Perspectives
Current Gene Therapy Recent Advances in the Prevention of Anthracycline Cardiotoxicity in Childhood
Current Medicinal Chemistry Anti-Apoptotic Actions of Insulin-Like Growth Factors: Lessons from Development and Implications in Neoplastic Cell Transformation
Current Pharmaceutical Design Exploring Modifications in Fetal Telomere Programming in Mothers Exposed to Multiple Risk Factors
Current Women`s Health Reviews Influence of Toll-Like-Receptor Ligands on the Dendritic Cell - T Cell Interactions: Therapeutic Options for Allergic Diseases? Mini-Review
Inflammation & Allergy - Drug Targets (Discontinued) Evaluation of Computed Tomography Scan Ability in Detecting Chest Nodules Using Tissue Equivalent Phantom
Current Medical Imaging Could Growth Factor-Mediated Extracellular Matrix Deposition and Degradation Offer the Ground for Directed Pharmacological Targeting in Fibrosarcoma?
Current Medicinal Chemistry Glycogen Phosphorylase Inhibitors
Mini-Reviews in Medicinal Chemistry Multifunctional Proteins in Tumorigenesis: Aminoacyl-tRNA Synthetases and Translational Components
Current Proteomics